Gene Symbol: ppp2r4 Gene Name: protein phosphatase 2A activator, regulatory subunit 4 Synonyms: pp2a, pr53, ptpa Add Xenopus synonyms Gene Function: Phosphotyrosyl phosphatase activator Interactants: cdk1(20) , ccnb1.2(12) , npy4r(12) , rasgrf1(10) , pold1(9) , mastl(8) , cdc25c(7) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >BC135674|Xenopus tropicalis hypothetical protein LOC100125159, mRNA (cDNA clone IMAGE:7634474), partial cds TGAGAAGCAGCAGCAGCAGACAGGTCATGTTGAGGATGAGATCCCTCCGTCCCTCGTCGGACACACGTTCATTGTGCCAAAGAAGGAGATTAACATGGTTCCAGACATGGTGAAGTGGAAGCGATCACAGGCCTACGCAGATTACATGGGATTCGTACTCGCGCTGAATGAGGGAGTCAAGGGGAAGAAACTGACCGATGATTATAAAGTCTCAGAGGTGATCCACAAACTGATGTCTCTGCTCGATACCTTGAATCGCTGGATCGATGAGATGCCCCCGGTAGACCAACCTTCCCGATTCGGCAACAAGGCCTTTCGCACCTGGTACGCCAAGCTCGATAAGGAAGCAGAGAATCTTGTTTCCACGGTGATCCCGGTGCATCTGAGTGCAGCGGTGCCCGAAGTGGCTGTATACCTAAAAGAATCTGTTGGAAACTCTACCCGCATTGACTATGGCACAGGTCACGAGGCTGCCTTTGCCGCTTTCCTGTGCTGCCTGTGTAAGATTGGCATTCTCAAGGTGGACGACCAACTAGCCATAGTCTTCAGAGTATTTAATCGGTATCTAGAAGTCATGAGGAAGCTGCAGAAGACCTACCGGATGGAACCGGCGGGCAGCCAAGGGGTCTGGGGCCTAGACGACTTCCAGTTTCTTCCTTTTATATGGGGAAGTGCTCAGCTTATAGATCATTCCATTTTGGAACCTAGGCATTTTGTGGATGAGAAGGTTGTGAATGAACATCACAAAGATTATATGTTCCTAGAGTGCATCTTGTTTATAACAGAGATGAAGACTGGACCTTTTGCAGAACACTCCAACCAGCTGTGGAACATCAGCGCTGTCCCTGCCTGGTCCAAAGTCAACCAAGGTCTCATTCGAATGTACAAGGCAGAGTGTTTGGAGAAGTTTCCGGTGATACAGCACTTTAAGTTCGGCAGCCTGTTGCCCATCCAGCCTGTCAAATCTTAAGGGATCCACGCCAAACGGGAAGCGCATTGCTCCAGGGCCAGCACCCGGGCCCCATCTTCCAGCATCCTCATCTCCTCCCCAGTCACAAAGCTGAGCGGGGGGGGGGGCTTTCCCTGTATTTATATTCTCCAGCCTGGAAGGATGCTACTTGGGGCTCTGTGTGGAACACATTTGGGGAGAGGAGTGAGGGACAGGAATCCATCGGCTCTAGCAGTAGTACATGTGTCTATAGGAATTGAGGGTACGTAATGGGTCTGTTTCTTTAGCTTCACATCTGCTTTTGCTTTGCAGGATTGGCAGCATCCCAATGCCAGTTTGCCCAATTCTCTGTACTATTAGCCCAGCCTGCGTTGCTTATGTCATCGTGTTTGGGTTCTAGAATGCTCCATTTCTCCTGCACTATACCAGCAGACATGGGTTTTTTTTTTTTACTTTGCCTGTGCCAGGTTCCTAAAAGCACACAGAATTCTTTAAACCAGCTTCTAATATTGTTCTGCTGTGGGCCAGGGCCAAACACACAGTTCTGGTTTCTCCTGCAGTCTATAGGCCATGTCAGGCAGACTGCACTAATAAAATTCCAAACCCCTAAAAAAAAAAAAAAA	Refseq >NM_001096031|Xenopus laevis protein phosphatase 2A activator, regulatory subunit 4 (ppp2r4), mRNA GCGTAGTTGAACGAGGTGAAAGGTGACAAAAAGCCCGGCTGCAGGAAGATGGCTGAGAAGGAGCAGAACACAGATCATGCAGAGGATGAGATCCCTCCGTCCCTCGTCGGACACACATTTATTGTACCAAAGAAGGAGATTAACATGGTTCCAGACATGGGCAAGTGGAAACGATCACAGGCCTACGCAGATTACATAGGGTTCGTACTTGCCCTGAACGAGGCAGTCAAGGGAAAGAAACTGACTGACGATTACACAGTCTCTGAGGTGATCCACAAACTGATGGCTCTGCTTGATACCTTGGATCGCTGGATCGACGAGACGCCCCCTATGGACCAACCTTCCCGATTCGGCAACAAGGCCTTTCGCACCTGGTATGCCAGGCTTGATAAGGAAGCGGAGAGTCTTGTTTCCACTGTGATCCCGGTGCATCTGAGTGCAGCAGTGCCCGAAGTGGCCTTATACCTAAAAGAATCCGTAGGAAACTCTACACGCATTGATTACGGCACAGGTCACGAGGCTGCCTTTGCCGCTTTCCTGTGCTGCCTGTGTAAGATTGGCGTTCTCAAGGTGGACGACCAACTAGCCATTGTCTTCAGAGTGTTCAACCGGTATCTGGAAGTCATGAGAAAGCTGCAGAAGACCTACCGAATGGAACCTGCGGGCAGCCAAGGGGTCTGGGGCTTGGATGACTTCCAGTTTCTTCCTTTTATATGGGGAAGTGCTCAGCTTGTAGATCATTCCACCTTGGAACCAAGGCATTTTGTGGATGAGAAGATAGTGAATGAAAATCACAAAGATTATATGTTCCTAGAGTGTATCCTGTTCATTACTGAGATGAAGACGGGACCTTTTGCAGAACACTCCAATCAGCTGTGGAACATCAGCGCTGTCCCTGCCTGGTCCAAAGTCAACCAGGGTCTCATTCGCATGTACAAAGCAGAGTGTTTGGAGAAGTTTCCAGTGATCCAGCACTTTAAGTTCGGCAGCCTGCTGCCCATCCAGCCTGTCAAATCTTAAAGGATCCAGGCCAGCGCTGAAAGCACATTGCTCCACCTCCAGCACCCCGGGCCCATCTTCCACCGCCCTCATCTTCTCCCCAGTCACCGACCCAGGGGTCTTCTTTGTATTTATATTCTTATGCCTGGAAGGATCCTACTGGGACTCTGTGGAACACATTTGGGGAGAGGAGCGAGGGACAGGAATCCGTTGGCTTTAGCAATAGTACATGCTCTTGTCTCTGTGTATATGAATTGAGGGTACGTAATGGGTTGCTCTAGGGGTCTGTTTCTTTAGCTTCACATCTGCTTCTACTTTACAGGATTGGCAGCCTTTGGCTCCCAACTGCAGGCATCCACCCGCCAGCCTAAATTTGCCCAATTCTCTGTAAAATCAGCCCAGCTTGCACTGCTCATGTGACAAGGTCTTGGGTTTCTTAGCCAGTTCTAGAATGCTCCATTTCTCCTGCACTATTCCAGCAGACACACGTAGGTCTTTTTTTATTTTCGTTTTTGCCTCTGCCAGTGTCCTAAAAGCACACAGAATTCTCTAAACCAGCTTCTAATATTGTTGTTCTGCTGTGAGCTAAACACAGAGTTCTAGTCTCTACTGCAATCTATAGGCCGGGTCAGGCAGACTGAGTTAATAAAATTCCAAAATCCAAAAAAAAAAAAAAAAA
Protein		NCBI Protein >AAI35675|LOC100125159 protein [Xenopus (Silurana) tropicalis] EKQQQQTGHVEDEIPPSLVGHTFIVPKKEINMVPDMVKWKRSQAYADYMGFVLALNEGVKGKKLTDDYKVSEVIHKLMSLLDTLNRWIDEMPPVDQPSRFGNKAFRTWYAKLDKEAENLVSTVIPVHLSAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGILKVDDQLAIVFRVFNRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSAQLIDHSILEPRHFVDEKVVNEHHKDYMFLECILFITEMKTGPFAEHSNQLWNISAVPAWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIQPVKS	Refseq >NP_001089500|protein phosphatase 2A activator, regulatory subunit 4 [Xenopus laevis] MAEKEQNTDHAEDEIPPSLVGHTFIVPKKEINMVPDMGKWKRSQAYADYIGFVLALNEAVKGKKLTDDYTVSEVIHKLMALLDTLDRWIDETPPMDQPSRFGNKAFRTWYARLDKEAESLVSTVIPVHLSAAVPEVALYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLKVDDQLAIVFRVFNRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSAQLVDHSTLEPRHFVDEKIVNENHKDYMFLECILFITEMKTGPFAEHSNQLWNISAVPAWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIQPVKS

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.14675	Xl.8828
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	PPP2R4
mouse		MGI	Ppp2r4	All(2) Targeted, knock Out(1)
zebrafish		ZFIN	ppp2r4	1 Lines(s)

Publications
First:		Isolation and characterization of a tyrosyl phosphatase activator from rabbit skeletal muscle and Xenopus laevis oocytes. [Biochemistry 1990]
Most recent:		Yeast Endosulfines Control Entry into Quiescence and Chronological Life Span by Inhibiting Protein Phosphatase 2A. [Cell Rep 2012]
		View All Papers 4 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		phosphatase activator activity
Biological:
Cellular Component:
EC:
KOG:		[DT] Phosphotyrosyl phosphatase activator

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.14675.1.S1_at	Xl.13693.1.A1_at [+] Xl.8828.1.S1_at
Affymetrix 2.0			Xl2.8828.1.S1_at

Symbol legend[+]

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