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Summary Expression Gene Literature (56) GO Terms (34) Nucleotides (235) Proteins (31) Interactants (618) Wiki

Gene Symbol: vangl2

Gene Name: VANGL planar cell polarity protein 2

Synonyms: stb1 , Strabismus , lpp1 , ltap , stbm , stbm1 , Van Gogh , vang-like 2 , vangl2-a , vangl2-b
Add Xenopus synonyms , Nomenclature history

Gene Function: Non-canonical wnt pathway signaling protein

Protein Function:
Has a role in non-canonical Wnt/planar cell polarity (PCP) signaling; can recruit dvl/dsh and prickle from the cytoplasm to the plasma membrane. Acts in a PCP complex to regulate the polarized assembly...[+]

Interactants: Loading ...

OMIM Disease Associations: NEURAL TUBE DEFECTS
Xenbase Gene ID XB-GENE-973460 XB-GENE-6251797 XB-GENE-973465
Gene Symbol vangl2 vangl2.L vangl2.S
Chromosome Chr08 chr8L chr8S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq Refseq
Protein Refseq Swiss-Prot TrEMBL Refseq Swiss-Prot TrEMBL Refseq Swiss-Prot TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.11014 Xl.10610 Xl.5981
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 30 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine vangl2 vangl2.L vangl2.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
MOD Entrez Gene Genetic Phenotypes Gene Expression
OMIM:Gene, HGNC, GeneCards VANGL2 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
MGI, AGR Vangl2 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
ZFIN, AGR vangl2 ZFIN Ensembl
fruit fly
First: Eye-specific segregation of optic afferents in mammals, fish, and frogs: the role of activity. [Cell Mol Neurobiol 1985]
Most recent: A novel role of the organizer gene Goosecoid as an inhibitor of Wnt/PCP-mediated convergent extension in Xenopus and mouse. [Sci Rep 2017]
View All Papers 8 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs
Functional Ontologies tropicalis laevis.L laevis.S
GO 33 terms 9 terms 8 terms
PANTHER vangl2
KEGG Pathways K04510 K04510 K04510
KOG [T] Signaling protein van gogh/strabismus
Reagents tropicalis laevis.L laevis.S
Clones   EXRC - 1 clone(s)  
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience Source BioScience
Antibody Vangl2 Ab1 , Vangl2 Ab2 , Vangl2 Ab3 Vangl2 Ab1 , Vangl2 Ab2 , Vangl2 Ab3 Vangl2 Ab1 , Vangl2 Ab2 , Vangl2 Ab3
Morpholino vangl2 MO1 , vangl2 MO2 , vangl2 MO3 , vangl2 MO4 , vangl2 MO5 , vangl2 MO6 vangl2 MO1 , vangl2 MO2 , vangl2 MO3 , vangl2 MO4 , vangl2 MO5 , vangl2 MO6 vangl2 MO1 , vangl2 MO2 , vangl2 MO3 , vangl2 MO4 , vangl2 MO5 , vangl2 MO6
ORF vangl2 ORF1 vangl2 ORF2
Affymetrix 1.0 Str.11014.1.S2_at [+] Xl.10610.1.S1_at Xl.5981.1.S1_at
Affymetrix 2.0 Xl2.10610.1.S2_at [+] Xl2.5981.1.S1_at

Symbol legend[+]
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