asic1 Summary [species: Xenopus laevis and Xenopus tropicalis]

Summary

Expression

XB-GENEPAGE-977698

[provisional- machine annotated only]

Gene Symbol: asic1 [Predicted: Source is Human Entrez Gene]

Gene Name: acid-sensing (proton-gated) ion channel 1 [Predicted: Source is Human Entrez Gene]

Synonyms: asic, bnac2, asic1a Add Xenopus synonyms

Gene Function: Non voltage-gated ion channels (DEG/ENaC family)

Interactants: asic3(21) , asic2(6) , asic4(3) , prss1(2) , bnc1(1) , cda(1) , cftr(1) View All

XB-GENE-977699

XB-GENE-13581814

Molecules	tropicalis	laevis
Gene	JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
	Entrez Gene
mRNA	NCBI Nucleotide >XM_002935733\|PREDICTED: Xenopus (Silurana) tropicalis amiloride-sensitive cation channel 2, neuronal-like (LOC100489966), mRNA CCCAAGTGATTGGTGATGCTGCAGCTTTACGATTAAATGACCGGAGTGAGAGAGCCCGGATGGATGTGAAAGAAGCAGAAGAGCTGGGCAGCCCCCAGCCACTGTCGGTCCAAGCCTTTGCAAGTGGGTCCACACTACATGGCCTTGCTCACATCTTCACATACGAGCGCTTCTCCTGTCGAAGGCTTATCTGGGTCCTGTGCTTCCTGGGCTCCTTATCTCTCCTGCTGTACGTCTGCACAGAGAGGATCATCTATTACTTTGAGTACCCGCATGTCACCAAACTGGATGAGATTTCTACTCCTAGGATGATCTTCCCAGCCGTGACCTTCTGTAATCTGAATGAATTCCGCTTCAGCCGCGTGACGAAAAATGACCTGTACCATGCAGGGGAGCTACTGAGCCTGCTCAACAACAGGTATGAACTCCCTGATTCTCAGTTGGCTGATGAGAAAGTGATGGAAATACTACAGGATAAAGCCAACTTCCGAAATTTTAAGCCAAAGCCGTTTAATATGCGTGAATTCTATGACCGAACAGGACACGACATCCGTGAGATGCTTCTGAGTTGCAAGTATCGGGGAGAGGAATGCAGCGTCGATGACTTTGTTCCAGTCTTTACCAGATATGGGAAGTGCTATACGTTTAACTCTGGGCGCAATGGGCGCTCTCCCTTAGTGACCACAAAAGGGGGCACAGGGAATGGACTGGAACTGATGCTGGACATCCAACAAGATGAGTATTTGCCTGTTTGGGGAGAGACAGATGAAACATCCTTTGAGGCTGGAATTAAGGTTCAGATTCATAGCCAAGATGAACCCCCTTTCATTGACCAGCTGGGCTTTGGTGTGGCTCCTGGATTTCAAACCTTTGTCTCCTGCCAAGAGCAACGACTAACCTACCTGCCGCCTCCATGGGGTGACTGCAAATCCAGCGCAATGGACTCAGAGTTTTTCGATACGTATAGTATCTCTGCCTGTCGGATTGACTGCGAGACCCGATATTTAGTGGAGAACTGTAACTGCCGCATGGTGCATATGCCAGGAGATGCTGCATACTGCACCCCGGAGCTGTACAAGGAATGTGCTGATCCAGCTCTAGATTTCCTGGTGGAGAAAGATAATGACTTCTGTGTATGTGAGACTCCCTGCAACATGACCCGCTATGGGAAGGAATTGTCCATGGTGAAAATCCCCAGCAAAGCCTCAGCGCGTTACCTGGCCAAGAAGTACAACAAAAGCGAGCAGTACATAGCGGAGAATATTTTGGTTCTTGATATCTTCTTCGAAGCCCTAAACTATGAAACTATTGAACAGAAGAAAGCATACGAGGTGGCCGGACTACTGGGTGACATTGGAGGACAGATGGGCCTGTTTATTGGAGCAAGTATTCTGACTGTTCTCGAACTCTTTGATTATGCCTACGAGGTGCTGAGATACAAACTCTGTGGAGGAGCAAAATGTGGGAAAGACTCAAAACGCAACAACAATGACAAAGGAGTAACGCTGAGTTTGGATGATGTAAAGCGCCATGCTCCATGTGAAGGAGTAAGAGGTCACCCAGCAGGAATGAGTTATACAGCCAACATTCTGCCTCACCATGCAGTGCGTGGTGCGTTTGAGGACTTTACATGCTGAGATCACATCTGAGGACAGACGAGAGAGCAAAGTCTTCTTCTAAAATTGACCATGAACATGAATCACAGATGAAAGAGAGAGAAAGAGCCTGAGAGTCTTTCCCACAGCTTACACAACAAAAATTGTCCATTGTAAAACAGAAAGAATGGAAACTGATCAGCCTGGAGAGTGTGAGACAACATGACTCAATGTAATACCTAAGCAAGTGAGGTGCTTGGGCGCTCATGACTACACTACGCCTAGGCTTTGGAAGGCAGTACCCTAAGGCAAGCCTTTCTGAATGACAGCAATCGTAATTTTAAAAAATGTACAATTTAGCATAAATACCTAAAGACAGCCAAAACGTCCAACACATGTTGAGCTCAGAGTACGGTGTAACCCTAATGTTTGGCACAATAATAACCATACATTTATGGCACAGCTTATCAAACCCATAAATAAATTATTGCCAAAACCAAACCAA
Protein	NCBI Protein >XP_002935779\|PREDICTED: amiloride-sensitive cation channel 2, neuronal-like [Xenopus (Silurana) tropicalis] MDVKEAEELGSPQPLSVQAFASGSTLHGLAHIFTYERFSCRRLIWVLCFLGSLSLLLYVCTERIIYYFEYPHVTKLDEISTPRMIFPAVTFCNLNEFRFSRVTKNDLYHAGELLSLLNNRYELPDSQLADEKVMEILQDKANFRNFKPKPFNMREFYDRTGHDIREMLLSCKYRGEECSVDDFVPVFTRYGKCYTFNSGRNGRSPLVTTKGGTGNGLELMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLTYLPPPWGDCKSSAMDSEFFDTYSISACRIDCETRYLVENCNCRMVHMPGDAAYCTPELYKECADPALDFLVEKDNDFCVCETPCNMTRYGKELSMVKIPSKASARYLAKKYNKSEQYIAENILVLDIFFEALNYETIEQKKAYEVAGLLGDIGGQMGLFIGASILTVLELFDYAYEVLRYKLCGGAKCGKDSKRNNNDKGVTLSLDDVKRHAPCEGVRGHPAGMSYTANILPHHAVRGAFEDFTC

Genomic	tropicalis
Genome Browser	Xenbase	Xenbase JGI Ensembl UCSC

Synteny	Metazome

Expression	tropicalis	laevis
UniGene	Str.36176 [+] Str.58663 Str.20865
Unigene EST Profile	EST Profile
GEO data		GEO
Images	0 expression image(s) for tropicalis and laevis

Orthology	MOD	Entrez Gene	Genetic Phenotypes	Morphants
human	OMIM:Gene, HGNC	ASIC1
mouse	MGI	Asic1	All(1) Targeted, knock Out(1)
zebrafish	ZFIN ZFIN	asic1b asic1a

Publications
First:		A proton-gated cation channel involved in acid-sensing. [Nature 1997]
Most recent:		Gating transitions in the palm domain of ASIC1a. [J Biol Chem 2013]
		View All Papers

Functional Ontologies
GO: Molecular:		amiloride-sensitive sodium channel activity sodium channel activity
Biological:		sodium ion transport
Cellular Component:		integral to membrane membrane
EC:
KOG:		[PT] Non voltage-gated ion channels (DEG/ENaC family)

Reagents	tropicalis	laevis
Clones	open biosystems
	geneservice/RZPD imagenes
Affymetrix 1.0	Str.44801.1.S1_at [+] Str.20865.1.A1_at Str.36176.1.A1_at Str.20865.3.S1_at StrEns.4024.1.S1_at StrEns.4026.1.S1_at StrEns.4025.1.S1_s_at StrEns.4025.1.S1_at
Affymetrix 2.0

Symbol legend[+]