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Summary Expression Gene Literature (21) GO Terms (12) Nucleotides (91) Proteins (31) Interactants (359) Wiki
XB-GENEPAGE-978018
Gene Symbol:
scn1a

Gene Name:
sodium channel, voltage gated, type I alpha subunit

Synonyms:
nav1.1 , Na(v)1.1 , feb3 , nac1 , scn1 , smei , hbsci , gefsp2 ( Add synonyms , Nomenclature history )

Gene Function:
Voltage-gated Ca2+ channels, alpha1 subunits

Protein Function :
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sod...[+]


InterPro :
Volt channel dom sf , Na channel asu , Na trans assoc , IQ motif EF-hand-BS [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
Lennox-Gastaut syndrome [+]

OMIM:
GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 1; GEFSP1 [+]

External Links:
1/2
 
Xenbase Gene ID XB-GENE-978019 XB-GENE-17343621 XB-GENE-978022
Gene Symbol scn1a scn1a.L scn1a.S
Chromosome Chr9 chr9_10L chr9_10S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model
Entrez Gene 100488621
378652
mRNA NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein  More.. NCBI Protein NCBI Protein
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine scn1a scn1a.L scn1a.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards SCN1A OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Scn1a MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Scn1a Ensembl
zebrafish
ZFIN, AGR scn1laa ZFIN Ensembl
chicken
GEISHA SCN1A Ensembl
fruit fly
Publications
First Chromosome-bound mitotic factors: release by endonucleases., Nucleic Acids Res 1982  
Most Recent Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions., Epilepsia 2019                      
All View All Papers 1 paper(s) referencing morpholinos 3 paper(s) referencing OMIMs 5 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 12 terms 0 term 0 term
PANTHER scn1a
KEGG Pathways
KOG [PT] Voltage-gated Ca2+ channels, alpha1 subunits
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks scn1a
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info