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Summary Expression Gene Literature (29) GO Terms (3) Nucleotides (46) Proteins (29) Interactants (206) Wiki
XB-GENEPAGE-980660
Gene Symbol:
lep

Gene Name:
leptin

Synonyms:
obesity homolog , leptin , xlep ( Add synonyms , Nomenclature history )

Gene Function:


Protein Function :
Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in t...[+]



Interactants:
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Diseases: 


Disease Ontology:
congenital leptin deficiency

OMIM:
LEPTIN DEFICIENCY OR DYSFUNCTION; LEPD

External Links:
 
Xenbase Gene ID XB-GENE-980661 XB-GENE-17342421 XB-GENE-980662
Gene Symbol lep lep.L lep.S
Chromosome Chr3 chr3L chr3S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.2 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100486715
108711253
734226
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein TrEMBL NCBI Protein TrEMBL NCBI Protein RefSeq  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine lep lep.L lep.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards LEP OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Lep MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Lep Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR lepb lepa ZFIN Ensembl
chicken
GEISHA LEP Ensembl
fruit fly
FLYBASE lep Ensembl
worm
Publications
First [Use of colloidal gold in ultrastructural cytochemistry]., Cesk Patol 1985  
Most Recent Comparative gene expression profiling between optic nerve and spinal cord injury in Xenopus laevis reveals a core set of genes inherent in successful regeneration of vertebrate central nervous system axons., BMC Genomics 2020                    
All View All Papers 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 2 terms 3 terms 3 terms
PANTHER lep
KEGG Pathways K05424 K05424 K05424
KOG
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks lep
Antibodies Lep Ab1 Lep Ab1 Lep Ab1
Morpholinos (on-target & off-target) lep MO1
Clones Horizon Source BioScience Horizon Horizon Source BioScience
Plasmids Addgene Addgene

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