Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (61) GO Terms (15) Nucleotides (70) Proteins (30) Interactants (64) Wiki
XB-GENEPAGE-981915
Gene Symbol:
wnk4

Gene Name:
WNK lysine deficient protein kinase 4

Synonyms:
pha2b , prkwnk4 ( Add synonyms , Nomenclature history )

Gene Function:
Serine/threonine protein kinase

Protein Function :



Interactants:
Loading ...

Diseases: 


OMIM:
PSEUDOHYPOALDOSTERONISM, TYPE IIA; PHA2A [+]

External Links:
 
Xenbase Gene ID XB-GENE-981916 XB-GENE-17330134 XB-GENE-17330135
Gene Symbol wnk4 wnk4.L wnk4.S
Chromosome Chr10 chr9_10L chr9_10S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100497207
108701024
108702721
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein NCBI Protein
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine wnk4 wnk4.L wnk4.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards WNK4 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Wnk4 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Wnk4 Ensembl
zebrafish
chicken
GEISHA WNK4 Ensembl
fruit fly
worm
Publications
First Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4., Proc Natl Acad Sci U S A 2003  
Most Recent Kidney-specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC., Am J Physiol Renal Physiol 2018  
All View All Papers 1 paper(s) referencing morpholinos 5 paper(s) referencing OMIMs 5 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 15 terms 2 terms 2 terms
PANTHER wnk4
KEGG Pathways K08867 K08867
KOG [R] Serine/threonine protein kinase
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks wnk4
Morpholinos wnk4 MO1 wnk4 MO1 wnk4 MO1
Clones Horizon Source BioScience Horizon Horizon

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.14.0
Major funding for Xenbase is provided by grant P41 HD064556