Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Phenotypes Gene Literature (9) GO Terms (41) Nucleotides (98) Proteins (48) Interactants (64) Wiki
XB-GENEPAGE-988967
???displayGene.symbol???:
 apaf1

???displayGene.name???: 
apoptotic peptidase activating factor 1

???displayGene.synonyms???
apaf-1 ( Nomenclature history )

???displayGene.geneFunction???
apoptosis/apoptosome scaffold protein with WD-40 domains, caspase recruitment domain (CARD), and an ATPase domain

Protein Function :
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.


InterPro :
WH-like DNA-bd sf, Apaf-1, WD40 repeat CS, DEATH-like dom sf, [+]

???displayGene.geneInteractants???
Loading ...

Diseases: 


External Links:
 
???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:


Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info