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XB-GENEPAGE-988967
Gene Symbol:
apaf1
Gene Name: apoptotic peptidase activating factor 1
Synonyms:
apaf-1
( Gene Function: apoptosis/apoptosome scaffold protein with WD-40 domains, caspase recruitment domain (CARD), and an ATPase domain Protein Function
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Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
Interactants:
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Diseases: External Links:
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Xenbase Gene ID | XB-GENE-988968 | XB-GENE-988971 | XB-GENE-17330402 | |||||
Gene Symbol | apaf1 | apaf1.L | apaf1.S | Chromosome | Chr3 | chr3L | ||
Molecules | X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genomic Sequence |
Version 10.0
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Version 9.2
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CDS |
Gene model
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Gene model
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Entrez Gene |
100127738
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444261
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mRNA |
NCBI Nucleotide
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NCBI Nucleotide
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Protein
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Genomic |
X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genome Browser (Click image to open in Genome Browser) |
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Genomic Synteny | Genomicus PANTHER | |||||||
Expression | Development Stages | Embryonic Tissues | Adult Tissues | |||||
Summary for |
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More Information |
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Proteomics | X. tropicalis | X. laevis.L | X. laevis.S | |||||
Embryonic Protein Expression | Stage profile:![]() |
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Data Mining | X. tropicalis | X. laevis.L | X. laevis.S | |||||
XenMine | apaf1 | apaf1.L | apaf1.S | |||||
Orthology |
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human |
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mouse |
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rat |
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zebrafish |
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chicken |
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fruit fly |
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worm |
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Publications | ||||||||
First |
Bcl-xL does not inhibit the function of Apaf-1., Cell Death Differ 2000 |
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Most Recent |
Identifying Regulators of Morphogenesis Common to Vertebrate Neural Tube Closure and Caenorhabditis elegans Gastrulation., Genetics 2016 |
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All | View All Papers 1 paper(s) referencing morpholinos 1 paper(s) referencing Disease Ontology | |||||||
Functional Ontologies | X. tropicalis | X. laevis.L | X. laevis.S | |||||
GO | 13 terms | 5 terms | 0 term | |||||
PANTHER | apaf1 | |||||||
KEGG Pathways | K02084 | K02084 | ||||||
KOG |
[T] Apoptotic ATPase
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Reagents | X. tropicalis | X. laevis.L | X. laevis.S | |||||
CRISPRscan Tracks | apaf1 | |||||||
ORFs | apaf1 ORF1 | apaf1.L ORF1 | ||||||
Clones | Horizon Source BioScience | Horizon Source BioScience | ||||||
Plasmids | Addgene | Addgene |
Symbol legend:



