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Summary Expression Gene Literature (9) GO Terms (13) Nucleotides (74) Proteins (28) Interactants (68) Wiki
Gene Symbol:

Gene Name:
apoptotic peptidase activating factor 1

apaf-1 ( Add synonyms , Nomenclature history )

Gene Function:
apoptosis/apoptosome scaffold protein with WD-40 domains, caspase recruitment domain (CARD), and an ATPase domain

Protein Function :
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

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External Links:
Xenbase Gene ID XB-GENE-988968 XB-GENE-988971 XB-GENE-17330402
Gene Symbol apaf1 apaf1.L apaf1.S
Chromosome Chr03 chr3L
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2
CDS Gene model Gene model
Entrez Gene 100127738
mRNA NCBI Nucleotide RefSeq
Protein NCBI Protein NCBI Protein  More.. NCBI Protein RefSeq  More..
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine apaf1 apaf1.L apaf1.S
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
HGNC AGR, OMIM:Gene, GeneCards APAF1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
MGI, AGR Apaf1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
RGD, AGR Apaf1 Ensembl
ZFIN, AGR apaf1 ZFIN Ensembl
fruit fly
First Bcl-xL does not inhibit the function of Apaf-1., Cell Death Differ 2000  
Most Recent Identifying Regulators of Morphogenesis Common to Vertebrate Neural Tube Closure and Caenorhabditis elegans Gastrulation., Genetics 2016  
All View All Papers 1 paper(s) referencing morpholinos 1 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 13 terms 5 terms 0 term
KEGG Pathways K02084 K02084
KOG [T] Apoptotic ATPase
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks apaf1
ORFs apaf1 ORF1 apaf1.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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