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Summary Expression Gene Literature (32) GO Terms (5) Nucleotides (134) Proteins (17) Interactants (54) Wiki
XB-GENEPAGE- 992186

Gene Symbol: clspn

Gene Name: claspin

Synonyms: xClaspin , claspin
Add Xenopus synonyms , Nomenclature history


Gene Function: regulation of cell cycle checkpoints

Protein Function:
Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by UV irradiation. Adapter protein which binds to the checkpoint kinase chek1 an...[+]


Interactants: Loading ...

OMIM Disease Associations:
1/4
 
Xenbase Gene ID XB-GENE-992187 XB-GENE-17339975 XB-GENE-6251915
Gene Symbol clspn clspn.L clspn.S
Chromosome Chr02 chr2L chr2S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 8.0 JBrowse 8.0 GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide Refseq
Protein NCBI Protein Refseq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.1621 [+] Xl.696
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 5 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine clspn clspn.L clspn.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards CLSPN OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Clspn MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
clspn ZFIN Ensembl
chicken
GEISHA CLSPN Ensembl
fruit fly
worm
WORMBASE
Publications
First: Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. [Mol Cell 2000]
Most recent: SUMOylation of the C-terminal domain of DNA topoisomerase II╬▒ regulates the centromeric localization of Claspin. [Cell Cycle 2015]
View All Papers
Functional Ontologies tropicalis laevis.L laevis.S
GO 0 term 0 term 5 terms
EC exo-a-sialidase
PANTHER clspn
KEGG Pathways
KOG [DT] Claspin, protein mediating phosphorylation and activation of Chk1 protein kinase in the DNA replication checkpoint response
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Antibody Clspn Ab1 , Clspn Ab2 Clspn Ab1 , Clspn Ab2
ORF MGC115738 ORF1
Affymetrix 1.0 Str.1621.1.S1_at [+] Xl.696.1.S1_at
Affymetrix 2.0 Xl2.54007.1.S1_at [+]

Symbol legend[+]

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