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Summary Expression Gene Literature (21) GO Terms (52) Nucleotides (104) Proteins (37) Interactants (61) Wiki
XB-GENEPAGE-992874
Gene Symbol:
wrn

Gene Name:
Werner syndrome, RecQ helicase-like

Synonyms:
Werner syndrome , ffa-1 , xwrn ( Add synonyms , Nomenclature history )

Gene Function:
ATP-dependent DNA helicase

Protein Function :
5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates c...[+]



Interactants:
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Diseases: 


Disease Ontology:
Werner syndrome

OMIM:
WERNER SYNDROME; WRN

External Links:
 
Xenbase Gene ID XB-GENE-992875 XB-GENE-992879 XB-GENE-17346623
Gene Symbol wrn wrn.L wrn.S
Chromosome Chr01 chr1L
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2
CDS Gene model Gene model
Entrez Gene 734043
398079
mRNA NCBI Nucleotide RefSeq
Protein NCBI Protein RefSeq Swiss-Prot
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine wrn wrn.L wrn.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards WRN OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Wrn MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Wrn Ensembl
zebrafish
ZFIN, AGR wrn ZFIN Ensembl
chicken
GEISHA WRN Ensembl
fruit fly
worm
Publications
First FFA-1, a protein that promotes the formation of replication centers within nuclei., Science 1995  
Most Recent Ligand binding characteristics of the Ku80 von Willebrand domain., DNA Repair (Amst) 2020  
All View All Papers 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 50 terms 15 terms 0 term
PANTHER wrn
KEGG Pathways K10900
KOG [L] ATP-dependent DNA helicase
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks wrn
Clones Horizon Source BioScience Horizon Source BioScience

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
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