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Summary Expression Gene Literature (19) GO Terms (12) Nucleotides (55) Proteins (30) Interactants (122) Wiki
XB-GENEPAGE-994090
Gene Symbol:
lgr5

Gene Name:
leucine-rich repeat containing G protein-coupled receptor 5

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
Glycoprotein hormone receptor

Protein Function :
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2,...[+]



Interactants:
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Diseases: 


External Links:
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Xenbase Gene ID XB-GENE-994091 XB-GENE-11536385 XB-GENE-17334059
Gene Symbol lgr5 lgr5.L lgr5.S
Chromosome Chr03 chr3L chr3S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100486389
100526795
108713148
mRNA NCBI Nucleotide RefSeq NCBI Nucleotide
Protein NCBI Protein Swiss-Prot RefSeq Swiss-Prot  More.. NCBI Protein NCBI Protein  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine lgr5 lgr5.L lgr5.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards LGR5 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Lgr5 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Lgr5 Ensembl
zebrafish
chicken
GEISHA LGR5 Ensembl
fruit fly
worm
Publications
First Spatio-temporal expression profile of stem cell-associated gene LGR5 in the intestine during thyroid hormone-dependent metamorphosis in Xenopus laevis., PLoS One 2010                      
Most Recent Effects of bisphenol A and its alternative bisphenol F on Notch signaling and intestinal development: A novel signaling by which bisphenols disrupt vertebrate development., Environ Pollut 2020  
All View All Papers 2 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 9 terms 6 terms 3 terms
PANTHER lgr5
KEGG Pathways K04308 K04308 K04308
KOG [T] Glycoprotein hormone receptor
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks lgr5
Morpholinos lgr5 MO1 , lgr5 MO2 , lgr5 MO3 lgr5 MO1 , lgr5 MO2 , lgr5 MO3 lgr5 MO1 , lgr5 MO2 , lgr5 MO3
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

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