rspo3 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (3)

Nucleotides (35)

Interactants (20)

XB-GENEPAGE-994473

Gene Symbol: rspo3 Gene Name: R-spondin 3 Add Xenopus synonyms Gene Function: subtilisin-like proprotein convertase; regulates the balance between angioblast and blood cell specification Interactants: rspo2(2) , acss2.2(1) , adam11(1) , aplnr(1) , bmp4(1) , dvl2(1) , fzd7(1) View All

XB-GENE-994474

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1
		Entrez Gene
mRNA		Refseq >NM_001129773\|Xenopus (Silurana) tropicalis R-spondin 3 (rspo3), mRNA CATTACAAGGTTACTATGCAATTGCGACTGCTTTCTCTGTGTTTTATCATATTGAACTTCTTGGAATACATTGACAGCCAGCAGATCCCCAGAGGGAGGCGACATCGGAGAATGCATCCTAATGTCAGCCAGGGTTGCCAAGGAGGATGTGCTACATGTTCTGATTATAATGGCTGTTTAACATGCAAGCCTCAGCTGTTTTTCGCTTTGGTAAGAAATGGAATGAAGCAAATTGGAGTCTGTCGTCCCTCCTGTCCAAATGGATATTTTGGGATACGATCACCAGAAATAAATAAATGTACAAAATGCAAAGCTGACTGTGAAACATGTTTCAACAAAAATTTCTGCACAAAGTGTAAAAGTGGATTTTACAAACACAACGGAAAGTGCTTAGACACATGTCCTGAAGGGTTTGAGAACAATCACAATATGGAGTGCACCAGTGTGGTGCACTGCGTAGTTGGGGAGTGGAGCGCTTGGGGTCCGTGCACAAAGAGGGGGAAAACCTGTGACATCAAGCGAGGAAATGAAACAAGGGTTCGGGAAATTTTACAATACCCTTCACCTAGGGGCACACCCTGTCCGCCAACATCCGAGACAAAAAAATGTGTAGTAAAGAGAAAGAAATGTCAAGACAGTCAAGACAGACAAAGGCCAAGAGGCAACAGAGATGAAATAAAAAAGAATAAACAAAGGCGAAAGAATGGTGACGCTCCCAGAAAACAAAGACAGAGAAAGCAAGAGAGAAATCAGCGAGAAGGAAAGAGAGGGGAGGGCAAAGTCTAA
Protein		Refseq >NP_001123245\|R-spondin 3 precursor [Xenopus (Silurana) tropicalis] MQLRLLSLCFIILNFLEYIDSQQIPRGRRHRRMHPNVSQGCQGGCATCSDYNGCLTCKPQLFFALVRNGMKQIGVCRPSCPNGYFGIRSPEINKCTKCKADCETCFNKNFCTKCKSGFYKHNGKCLDTCPEGFENNHNMECTSVVHCVVGEWSAWGPCTKRGKTCDIKRGNETRVREILQYPSPRGTPCPPTSETKKCVVKRKKCQDSQDRQRPRGNRDEIKKNKQRRKNGDAPRKQRQRKQERNQREGKRGEGKV

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC

Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.27436 [+] Str.50796
Unigene EST Profile		EST Profile
GEO data			GEO
Images		3 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	RSPO3
mouse		MGI	Rspo3	All(3) Targeted, other(1)
zebrafish		ZFIN	rspo3

Publications
First:		R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. [Dev Cell 2004]
Most recent:		Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis. [Dev Cell 2011]
		View All Papers 3 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		electron transporter activity iron ion binding
Biological:		electron transport
Cellular Component:
EC:
KOG:		[O] Subtilisin-like proprotein convertase

Reagents		tropicalis	laevis
Clones		open biosystems
		geneservice/RZPD imagenes
Affymetrix 1.0		Str.50796.1.S1_at [+] Str.27436.1.S1_s_at Str.50187.1.A1_at
Affymetrix 2.0

Symbol legend[+]