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Summary Expression Gene Literature (11) GO Terms (17) Nucleotides (46) Proteins (25) Interactants (90) Wiki
XB-GENEPAGE-996925
Gene Symbol:
tph1

Gene Name:
tryptophan hydroxylase 1

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
Aromatic amino acid hydroxylase

Protein Function :
Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.


InterPro :
LisH , Galactose-bd-like sf , Muskelin N , Kelch-typ b-propeller [+]

Interactants:
Loading ...

Diseases: 


External Links:
 
Xenbase Gene ID XB-GENE-996926 XB-GENE-996927 XB-GENE-17337136
Gene Symbol tph1 tph1.L tph1.S
Chromosome Chr4 chr4L
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1
CDS Gene model Gene model
Entrez Gene 100497239
387560
mRNA NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine tph1 tph1.L tph1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards TPH1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Tph1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Tph1 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR tph1a tph1b ZFIN Ensembl
chicken
GEISHA TPH1 Ensembl
fruit fly
Publications
First An update on MyoD evolution in teleosts and a proposed consensus nomenclature to accommodate the tetraploidization of different vertebrate genomes., PLoS One 2008          
Most Recent Serotonin and MucXS release by small secretory cells depend on Xpod, a SSC specific marker gene., Genesis 2020                
All View All Papers 2 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 17 terms 4 terms 0 term
PANTHER tph1
KEGG Pathways K00502
KOG [E] Aromatic amino acid hydroxylase
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks tph1
Clones Horizon Horizon Source BioScience
Plasmids Addgene Addgene

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