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Summary Expression Gene Literature (5) GO Terms (12) Nucleotides (100) Proteins (39) Interactants (290) Wiki
XB-GENEPAGE-996985
Gene Symbol:
notum

Gene Name:
notum, palmitoleoyl-protein carboxylesterase

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
Pectin acetylesterase and similar proteins

Protein Function :
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required f...[+]


InterPro :
PAE/NOTUM , Ig sub2 , Ig-like fold , Ig-like dom sf [+]

Interactants:
Loading ...

Diseases: 


External Links:
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Xenbase Gene ID XB-GENE-996986 XB-GENE-996989 XB-GENE-17335322
Gene Symbol notum notum.L notum.S
Chromosome Chr10 chr9_10L chr9_10S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100145278
444338
108702711
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More.. NCBI Protein Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine notum notum.L notum.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards NOTUM OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Notum MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Notum Ensembl
zebrafish
chicken
GEISHA NOTUM Ensembl
fruit fly
FLYBASE Notum Ensembl
Publications
First Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation., Dev Cell 2015                                    
Most Recent Establishing embryonic territories in the context of Wnt signaling., Int J Dev Biol 2021        
All View All Papers 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 9 terms 6 terms 6 terms
PANTHER notum
KEGG Pathways K19882 K19882
KOG [M] Pectin acetylesterase and similar proteins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks notum
Antibodies Notum Ab1
Morpholinos Notum MO1 Notum MO2
ORFs notum.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

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