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Summary Expression Gene Literature (27) GO Terms (17) Nucleotides (233) Proteins (51) Interactants (370) Wiki
XB-GENEPAGE-997351
Gene Symbol:
ndc80

Gene Name:
NDC80 kinetochore complex component

Synonyms:
xndc80 , hec1 , kntc2 ( Add synonyms , Nomenclature history )

Gene Function:
Centromere-associated protein HEC1

Protein Function :
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12514103, PubMed:14738735). Required for ...[+]



Interactants:
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Diseases: 


External Links:
 
Xenbase Gene ID XB-GENE-997352 XB-GENE-17345905 XB-GENE-997357
Gene Symbol ndc80 ndc80.L ndc80.S
Chromosome scaffold_327 chr2L chr2S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 496580
779317
398429
mRNA RefSeq RefSeq RefSeq
Protein RefSeq Swiss-Prot RefSeq RefSeq Swiss-Prot Swiss-Prot
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine ndc80 ndc80.L ndc80.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards NDC80 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Ndc80 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Ndc80 Ensembl
zebrafish
ZFIN, AGR ndc80 ZFIN Ensembl
chicken
GEISHA NDC80 Ensembl
fruit fly
FLYBASE Ndc80 Ensembl
worm
Publications
First The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity., Genes Dev 2003  
Most Recent Chromosome alignment maintenance requires the MAP RECQL4, mutated in the Rothmund-Thomson syndrome., Life Sci Alliance 2019                          
All View All Papers 1 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 16 terms 3 terms 11 terms
PANTHER ndc80
KEGG Pathways K11547 K11547 K11547
KOG [D] Centromere-associated protein HEC1
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks ndc80
ORFs ndc80 ORF1 kntc2 ORF1 ndc80.S ORF1
Clones Horizon Source BioScience Horizon Horizon Source BioScience

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