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Summary Expression Gene Literature (3) GO Terms (17) Nucleotides (154) Proteins (33) Interactants (168) Wiki
XB-GENEPAGE-998159
Gene Symbol:
c8b

Gene Name:
complement C8 beta chain

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
Immunoglobin and related proteins

Protein Function :
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.



Interactants:
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Diseases: 


Disease Ontology:
type II complement component 8 deficiency

OMIM:
COMPLEMENT COMPONENT 8 DEFICIENCY, TYPE II; C8D2

External Links:
 
Xenbase Gene ID XB-GENE-998160 XB-GENE-6488069 XB-GENE-17336237
Gene Symbol c8b c8b.L c8b.S
Chromosome Chr4 chr4L
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1
CDS Gene model Gene model
Entrez Gene 100380076
108714245
mRNA NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein TrEMBL
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine c8b c8b.L c8b.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards C8B OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR C8b MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR C8b Ensembl
zebrafish
ZFIN, AGR c8b ZFIN Ensembl
chicken
GEISHA C8B Ensembl
fruit fly
Publications
First Xenopus cDNA microarray identification of genes with endodermal organ expression., Dev Dyn 2007                      
Most Recent Transcriptomic analysis identifies early cellular and molecular events by which estrogen disrupts testis differentiation and causes feminization in Xenopus laevis., Aquat Toxicol 2020  
All View All Papers
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 17 terms 7 terms 0 term
PANTHER c8b
KEGG Pathways K03998 K03998
KOG [RP] FOG: Immunoglobin and related proteins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks c8b
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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