casp1 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (7)

Interactants (11)

XB-GENEPAGE-485194

Gene Symbol: casp1 Gene Name: caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) Synonyms: ICE, interleukin-1beta-converting enzyme, xice, caspase 1, caspase-1 Add Xenopus synonyms Gene Function: apoptotic cysteine protease Interactants: bcl2(2) , casp2(2) , casp3(2) , amd1(1) , casp8(1) , casp9(1) , p2rx7(1) View All

XB-GENE-485195

XB-GENE-6077552

XB-GENE-6252623

Molecules		tropicalis	laevis a		laevis b
Gene		JGI XT Genome 4.1 Ensembl
			Entrez Gene		Entrez Gene
mRNA		JGI mRNA >e_gw1.135.137.1 CTTGCAGCTCAGCTGAAAAAAGTGCGCAAACTCTTTATAGATGGATGTAATGCCGCAATTATCAACAATTTACTAGATGATTTGCTGGATAAAAGTGTACTAACAGATTCTGAAGTGGAGTACATCAATGAGTGCAATGCCATAACCAAGGACAGATGCCGGCGTATGATTGACAATATAAAGAATAAAGGAGATTATTCTAGCAACATTCTTCTTCAGTGCTTGGTGGAGAATCACAAGACGCTGGCCAAAAACATGGGACTTGATGAACCTGCTATTGCACCCCAACCCATACAAGAGCAGAATAAGAAGACAAATGAGAACACAGAAATCAGCAGCGTGATTCATTGTTCGGATAAAGATTTCAAGGAAATTCATGACACTCAAGGAGATAAGATTTATGAAATGCGGAAGCGTGAAGGACGGAAGCGCTTCGCTCTAATCATCTGTAATGAAAAGTTTGAGACTCTGACTGAGCGCCAAGGGGCCAAGGTTGATCTGGATGGGATGACCAAATTACTAAATGAATTAGGATACCAAGTCCTTCAAGAAACAAACTTGGCAAAAGAGGAAATGCTGAAGGTGTTGAAGGAGTTTGCAGCCCGGGAGGAGCATGTGGATTCAGACAGCACCTTCATAGTACTGATGTCTCATGGAGATAAGCCAGGAGTCTGTGGGACAGACAGCAAGAAGATAGAACATGAAAAAGGACAGTGTCAGGTGACTAACCTGCTACAGACGGATGAAATTTTTTCTATATTCAACAATATCCATTGCCCGAAACTGCGGGACAAACCAAAAGTCATTATTATTCAGGCCTGCCGTGGGGAAGAAAGAGGCCAAAAATTAGTCTGTGATGCTGTGGCTTTGCCCCCAGAGGAACAATTGGAAGATGATGCACTCCATAGAGTTCAAAGAGAGACTGACTTCATTTGCTTCTGTTCTTCAACCCCAGATACTGTTTCTTGGAGACATCCTACCATGGGTTCCTTGTTCATCACAGGTCTGATTAAAAAAATGAATGAATTAGCCCATTGCCAGCCATTGATGGACATCTTCCTTGAAGTACAATCCTCGTTTAAGGGTCAAAGGCAGATGCCCACACAAGAGAGGAGTACGCTGACAAAGAAATTTTACCTTTTCCCAGGCCACTGA	Refseq >NM_001087754\|Xenopus laevis xice-a protein (casp1-a), mRNA TTTATCCTGTGTACATTATAGCTGCATTGCTGCTCGCCAGATATGACAGCTCAACTGAATAAAGTGCGCAGAGCCATTATAGATGGATGTAACCCTGCAATGATAAGTGATTTACTAGATGATTTGCGAGAAAAAAATGTACTTGTGGACTCCGAAGTGGAACACATCAAAGAGAGCAATAACACAAACAGGGACAGATGCCGGGCCATGATTGACAGTGTAAAGAAAAAAGGAGACGACCCAAGCAATATTCTACTTGAGAGCTTGGTGAAGAATCACAAAACTCTCGCCAAAAGCCTGGGACTCCACGAACCTCCTATGGCACCCGTGCCCATTCAAGAACATAATGCGGATACAATTAAGAACAAAGACATCAAAGGTGTAATTCCTTGTTCTGCTGAAGAATTCAAGAAAATTCAGGACACTCAAGGAGATAAGATTTATGATGTGCGGAAGCGTGAAGGACGGAAGGGCTTGGCTCTTATAATCTGCAATGAAAAGTTTGAGAATCTGAACGAGCGCCATGGAGCCAAGGTTGATCTGGATGGGATGACCAAATTACTAAATGAATTAGGATACCAAGTCCATCCACATACAAACTTGACAAAAACAGAAATGGTGAAGGTGATGAAGGAGTTTGCTGCCCAGGAGGAGCATGCAGATTCAGACAGCACCTTCATAGTTCTGATGTCTCATGGAGATAGGCAGGGAGTCTGTGGGACAGACAGCAAGAAGACAGAAAAAGAAAAAGGACAGTATGAGGTGACTAACCTGCTGGAGATCGATGAAATCTTTTCTACATTCAATAATGTCAATTGCTCTAAATTGCGGAACAAACCGAAAGTCATCATTATTCAGGCCTGCCGTGGGGAAAATAAAGGTGGATTATTAGTCCGTGATGATGTGGCTTCGCCCCCTCTGGAAGATGATGGGCTCCATTTTGTCCAGAGAGAGGCAGACTTTATATGCTTCTGTTCTTCAACTCCAGACACTGTTTCTTGGAGAGATCCTACAAAGGGTTCCGTGTTCATCACACATCTGATTGAGAAAATGAATGAATACGCTCATTGCCAACCACTGGGGGATATCTTTCTTGAAGTGCAGTCCTTGTTTAAGGATAAATGCCCAAACTCACGCTCACAGATGCCCACACAAGAGAGATGTACACTGACAAAGAAATTTTACCTTTTCCCAGGCTACTAATGTAAGGAATTAATGAATGGATTAAAGAACATCAAGAGCTTTTTGTTTAGGTTTTTTCCCTCTGCAGCAAAATGGGTTAAAGAAGAACTAAAGACTAACTAAAGATGATAGCCAGAAATGTTGTACATTATGTTTTGTGCTTCTGTACCAGCCCAAGGCAAACACAGCCCTTTAGCAGTAAGGATCTGTGTCTCCAAAGATGCCCCAGTAGCTCCTCATCTTCTTTTCTGCTGATTCACTGCACATGCTCTGTGCTGCTGTCACTTACTGAGCTTAGGGACCCACTTACAATATATAGTACACATAGAATATAATTGTCACAATATAAGGCTTTATTAATACAGATAATTACTACATCGCAGCTCAGAAACCAGTGCAATTAGCATCAGAATTTAACAATCAGCCCTGTAGCATCTGTTTATATTACAGACAAACCCCCCTAAGCCCCTAAGCTTAGCTTCTCAACAGCTGCTCAGAGCCCACCGAGTATGTGAAAGTCACAGACACTTTTCAAGATGGTGACCCCCTGTGACAAGTTTGAAGTTCTGGATCATTGCTGCTATTGACAAGCTGAAACTTTAGGCTGGTGCAATAAGTTCAGTATATAAAATATGGCATTTTTGGCCATATTCATTTTCAGGCTTTAGTTCTCCTGTAAGTGTTTAGGGGTGTCTCTTATTCCTTACAACATGACGGTAGCATTTAAACATTTTTACCACTGTGCCTTAAAATAATGAGCAATATTAAAATAAAAATACATTTTTAAAAAGAAAAAAAAAAAAAAAAAAAA		Refseq >NM_001085872\|Xenopus laevis caspase 1b, apoptosis-related cysteine protease (interleukin 1, beta, convertase) (casp1-b), mRNA CTGAACGCAAGTAATTTATCCTGTGTATAATATAGCTGTCTTGCTACTCTAGATATGACAGCTCAGCTAAATAAAGTGCGTAAAGCCATTATAAATGGATGCAACCCTGCAATGATTAGTGATTTACTAGATGATTTGCAAGACAAACATGTACTTAAGGACTATGAAGTGGAACACATTAATAAGAAAAATAACACAAGCAGAGACAGATGCCGGGACATGATTGACAGTGTAAAGAAAAAAGGAGAGTACTCAAGCAACATTCTTCTTGAGAGCCTGGTGAAGAATCACAAAACACTGGCTGAAAGCCTGGGACTCCACGAACATGCACCGTCGCCCATTCAAGAACATAATGAGGATACAATTAAGGACAAAGAAATCAACAGTGTAATTCCTTGTTCTGCTGAAGAATTCAAGAACATTTATGACTCTCACGGAGATAAGATTTATGAAGTGCGGGAACGTGAAGGACGGAAGCGCTTGGCTCTTATAATCTGCAATGAAACGTTTCAGTCTATGAGTGAGCGTCGAGGGGCCAAGCTTGATCTGGAAGGGATGAACAAATTACTAAATGAATTAGGATACCAAGTCCAGCAACATACAAACTTGACAAAAGCGGAAATGGTGAAGGCAATGAAGGAGTTTGCAGCCCGGGAGGAGCATGCAGATTCAGACAGCACCTTCATAGTTTTGATGTCTCATGGAGATAAGCCGGGAGTCTGTGGGACGGACAGCAAGAAGACAGAAAATGGACAGTATGGGGTGACTAACCTGCTACAGGTGGATGAAATCTTTTCTACATTCAACAATGTTAATTGCTCTAGATTGTGGGACAAACCAAAAGTCATCATTATTCAGGCCTGCCGTGGGGAAAATCAAGGCGGAGAATTAGTCCGTGATGATGTGGCTCCGGCCCCTCTGGAAGATGATGCAGTCCATCATGTTCAAACAGAGACAGACTCCATATGCTTTTATTCTTCTACACCAGATACTGCTTCTTGGAGAAATCCTACAAAGGGTTCTGTGTTCATCATACGTCTGATTGAGAAAATGAATGAATTAGCTCATTGTCAACCACTAGGCGACATATTTCTTGAAGTACAGTCCTCGTTTAAGGATAAATCCCCAAACCAATACTCACAGATGCCCACACAAGAGAGATCTACAATGACAAAGAAATTTTACCTTTTCCCAGGCTACTGACGTAAGGAATTAATGAACGGAATCAATAACATCAAGAGCTTTGAATTTAGATTTTTTTTTCCTCTGCAGCAAAATGGGTTAAGTGTTTTGGGGTGTCTCTAAAATCCTATCAACATGACGGTAGCGTCTTAAATCTTTTAAAACAATGAGTGATATTAAACAAAAATAAATGAAAAAAATGTAACTGTTTAAATAAATACAGTAACTAGAAAAAAAAAAAAAG
Protein		JGI protein >e_gw1.135.137.1 LAAQLKKVRKLFIDGCNAAIINNLLDDLLDKSVLTDSEVEYINECNAITKDRCRRMIDNIKNKGDYSSNILLQCLVENHKTLAKNMGLDEPAIAPQPIQEQNKKTNENTEISSVIHCSDKDFKEIHDTQGDKIYEMRKREGRKRFALIICNEKFETLTERQGAKVDLDGMTKLLNELGYQVLQETNLAKEEMLKVLKEFAAREEHVDSDSTFIVLMSHGDKPGVCGTDSKKIEHEKGQCQVTNLLQTDEIFSIFNNIHCPKLRDKPKVIIIQACRGEERGQKLVCDAVALPPEEQLEDDALHRVQRETDFICFCSSTPDTVSWRHPTMGSLFITGLIKKMNELAHCQPLMDIFLEVQSSFKGQRQMPTQERSTLTKKFYLFPGH*	Refseq >NP_001081223\|caspase-1-A precursor [Xenopus laevis] MTAQLNKVRRAIIDGCNPAMISDLLDDLREKNVLVDSEVEHIKESNNTNRDRCRAMIDSVKKKGDDPSNILLESLVKNHKTLAKSLGLHEPPMAPVPIQEHNADTIKNKDIKGVIPCSAEEFKKIQDTQGDKIYDVRKREGRKGLALIICNEKFENLNERHGAKVDLDGMTKLLNELGYQVHPHTNLTKTEMVKVMKEFAAQEEHADSDSTFIVLMSHGDRQGVCGTDSKKTEKEKGQYEVTNLLEIDEIFSTFNNVNCSKLRNKPKVIIIQACRGENKGGLLVRDDVASPPLEDDGLHFVQREADFICFCSSTPDTVSWRDPTKGSVFITHLIEKMNEYAHCQPLGDIFLEVQSLFKDKCPNSRSQMPTQERCTLTKKFYLFPGY UniProtKB		Refseq >NP_001079341\|caspase-1-B precursor [Xenopus laevis] MTAQLNKVRKAIINGCNPAMISDLLDDLQDKHVLKDYEVEHINKKNNTSRDRCRDMIDSVKKKGEYSSNILLESLVKNHKTLAESLGLHEHAPSPIQEHNEDTIKDKEINSVIPCSAEEFKNIYDSHGDKIYEVREREGRKRLALIICNETFQSMSERRGAKLDLEGMNKLLNELGYQVQQHTNLTKAEMVKAMKEFAAREEHADSDSTFIVLMSHGDKPGVCGTDSKKTENGQYGVTNLLQVDEIFSTFNNVNCSRLWDKPKVIIIQACRGENQGGELVRDDVAPAPLEDDAVHHVQTETDSICFYSSTPDTASWRNPTKGSVFIIRLIEKMNELAHCQPLGDIFLEVQSSFKDKSPNQYSQMPTQERSTMTKKFYLFPGY UniProtKB

Genomic

tropicalis

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Synteny

Xenbase G-Browse

GBrowse

Expression		tropicalis	laevis a		laevis b
UniGene			Xl.126		Xl.138
Gurdon EST/FL		CAAP6129	IMAGE:8461827
Affymetrix 1.0					Xl.138.1.S1_at
GEO data			GEO		GEO

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene	CASP1
mouse		MGI	Casp1	All(4) Targeted, knock Out(2) Targeted, other(2)
zebrafish		ZFIN	caspb

Publications
First:		Bcl-2 regulates activation of apoptotic proteases in a cell-free system. [Curr Biol 1996]
Most recent:		The pannexin 1 channel activates the inflammasome in neurons and astrocytes. [J Biol Chem 2009]
		View All Papers

Functional Ontologies
GO: Molecular:		caspase activity caspase activity (obsolete GO:0004199) caspase-1 activity More[+] protein binding
Biological:		proteolysis regulation of apoptosis
Cellular Component:		intracellular
EC:		caspase-1
KOG:		[D] Caspase, apoptotic cysteine protease

Suppliers		tropicalis	laevis a		laevis b
Clones			open biosystems		open biosystems
		geneservice	geneservice		geneservice
		RZPD imagenes	RZPD imagenes		RZPD imagenes

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