cdk2 Summary [species: Xenopus laevis and Xenopus tropicalis]

Summary

Expression

Gene Literature (176)

XB-GENEPAGE-1001989

[provisional- machine annotated only]

Gene Symbol: cdk2 [Predicted: Source is Human Entrez Gene]

Gene Name: cyclin-dependent kinase 2 [Predicted: Source is Human Entrez Gene]

Synonyms: eg1 Add Xenopus synonyms

Gene Function: Protein kinase PCTAIRE and related kinases

Interactants: cdk1(85) , pold1(56) , ccnb1.2(35) , cdkn1a(21) , cdc25c(18) , cdknx(18) , rasgrf1(17) View All

XB-GENE-1001990

XB-GENE-1001995

Molecules	tropicalis	laevis
Gene	JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
	Entrez Gene	Entrez Gene
mRNA	Refseq >NM_001008135\|Xenopus (Silurana) tropicalis cyclin-dependent kinase 2 (cdk2), mRNA CGGAAGTTCGTCCTGTTATTGAGTCCGATTTGGTTCCAATTTGTGGGACTGAATTTTACAGTAGTGGCGGGGGGCCATGGAGAATTTCCAGAAGGTGGAGAAGATCGGGGAGGGCACGTACGGGGTGGTGTACAAAGCGCGGAACCGAGAGACCGGGGAGATTGTGGCTCTGAAAAAGATTCGCTTGGACACTGAGACAGAAGGAGTTCCAAGCACAGCCATCCGGGAAATTTCCCTCCTCAAAGAATTGAACCATCCCAATATTGTGAAGCTTCTTGATGTCATTCATACAGAAAACAAGCTCTACCTTGTATTTGAGTTCCTTAACCAAGATCTGAAGAAATTCATGGACGGTTCAAACATTTCTGGAATTTCACTAGCCCTAGTTAAAAGCTATCTGTTCCAGTTGCTCCAAGGTTTGGCTTTCTGCCACTCACATCGTGTCTTACATCGTGACTTAAAACCACAGAACCTGCTTATTAATTCTGAGGGTGCCATCAAACTTGCCGACTTTGGACTAGCTCGGGCATTTGGTGTGCCTGTGAGAACCTATACTCATGAGGTTGTCACCCTGTGGTACAGAGCACCAGAAATTCTTCTTGGCTGCAAGTTCTACTCCACGGCTGTAGATATCTGGAGCCTGGGATGTATATTTGCAGAAATGATCACTAGGAGAGCACTTTTTCCTGGAGATTCTGAAATTGATCAGCTCTTTCGCATCTTTCGAACACTGGGGACCCCTGATGAAGTGTCCTGGCCAGGAGTGACAACTATGCCAGATTACAAGTCAACCTTTCCTAAGTGGGTCCGACAGGACTTTAGCAAAGTGGTGCCACCTTTGGATGATGATGGTAGAGACCTTTTAGCTCAAATGCTTCAGTATGACTCCAACAAGCGGATTTCTGCTAAAGCAGCGCTGACCCATGCTTTCTTCCGAGATGTGAGCAGACCAACTCCGCATCTGATTTAGATGTACACATGGAGGAGAAGCGTACAATAGTTTATAAGGAGATGACAGAAAATGAGCAGTGTGGAACTTGGCAACCACCCTTGTAAGAATAACTCTGTATCCATCAGATCTATTTCACAAAGTACAGAGAATTGGCATCATTTTTAAGTAAATTGTTCCTTTGCAAAAGAAGTTTTTCATGCTATAATCCAACTACTTTCAAATTCTTTCGACATCTACAGTTTGGGAATCTCCTGAAGAGTATAAACAGCTAGGATTTTAATCTTGTAACTCGGTTCAGCAAGTTAATTTCTTTTTTCTCTTTCTATTTTCAGATTACCAAAACTTTTTACTCTTAATGGTGTGTGCAAAAAAAAAAAAAATGCATCCGTTTTTAAGGAGCAAGTCACCTTTTTAGGTCAGGCGCTATAAGCACTTTGGTGCTGCTATTTATTTTCTAGCATATTTCATTGAGTGGAATATTTTAGACTTCCTAATGCTCTGTGAAATGTAAAATTGCAATATTCTCTACTGAATTATTATATCCAATGTCCGTCTCAACATACCTTGTATGCTTGTAATACAGGCACAACTGGTAGCATTGTTGAAATAGGTTAGGATGCTGTACAGCACACTATGAACCATATGTGTTAAATATTGTGTGCAGAACATAGATAAAAGTATTAAGAGGAAGTTCTACAACAAAACAAGAAATCTCTTTTGTAAAATGTTGTTTTTGCACCTTTTATTTTTGGATGCAACTACTTTTAAAATTATGTTTTAACTGTTCAATGTGTGTTTTAGTCTGTACCTGTGATGTTAGTCCTAAAGTTAATTAAAATAATATTATTACTATGCTGGTGAAGAGTTTTAAAATAAAGTACAGTTCTCTAGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001090651\|Xenopus laevis cyclin-dependent kinase 2 (cdk2), mRNA GAATTCCCAGCAGTGTCCCCCGGCCATGGAGAATTTCCAGAAGGTGGAGAAGATCGGGGAGGGCACGTACGGGGTGGTGTACAAGGCTCGGAACAGAGAGACCGGGGAAATTGTGGCTCTGAAAAAGATACGCTTGGACACTGAGACAGAAGGAGTTCCAAGCACAGCCATCCGGGAAATTTCCCTCCTCAAAGAACTGAACCATCCCAACATTGTGAAGCTTCTTGATGTCATTCATACGGAAAACAAGCTCTACCTTGTCTTCGAGTTCCTTAACCAAGATCTGAAGAAATTCATGGACCGGTCAAACATTTCTGGAATTTCATTGGCCCTAGTTAAAAGCTATCTGTTCCAGTTGCTTCAAGGTTTGGCTTTCTGCCACTCACATCGTGTCTTACATCGTGATCTAAAACCACAGAACCTGCTTATTAATTCTGATGGAGCCATCAAACTTGCCGACTTTGGACTAGCTCGGGCATTTGGTGTGCCTGTGAGAACCTTCACTCATGAGGTTGTCACTCTGTGGTACAGAGCACCAGAAATCCTTCTTGGCTGCAAGTTCTACTCCACGGCTGTAGATATCTGGAGCCTGGGATGTATTTTTGCTGAAATGATCACCAGGAGAGCGCTTTTTCCAGGAGATTCTGAAATTGATCAGCTTTTTCGTATCTTTCGAACACTGGGGACCCCTGATGAAGTGTCCTGGCCAGGAGTCACAACTATGCCAGATTACAAGTCAACCTTTCCCAAGTGGATCCGACAAGACTTTAGCAAAGTGGTACCACCTTTGGATGAGGATGGTAGAGATCTTTTAGCTCAAATGCTTCAGTATGACTCCAACAAACGGATTTCTGCTAAAGTAGCGCTGACCCATCCTTTCTTCCGAGATGTGAGCAGACCTACTCCACATCTGATTTAG
Protein	Refseq >NP_001008136\|cyclin-dependent kinase 2 [Xenopus (Silurana) tropicalis] MENFQKVEKIGEGTYGVVYKARNRETGEIVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLNQDLKKFMDGSNISGISLALVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINSEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKFYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPDEVSWPGVTTMPDYKSTFPKWVRQDFSKVVPPLDDDGRDLLAQMLQYDSNKRISAKAALTHAFFRDVSRPTPHLI	Refseq >NP_001084120\|cyclin-dependent kinase 2 [Xenopus laevis] MENFQKVEKIGEGTYGVVYKARNRETGEIVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLNQDLKKFMDRSNISGISLALVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINSDGAIKLADFGLARAFGVPVRTFTHEVVTLWYRAPEILLGCKFYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPDEVSWPGVTTMPDYKSTFPKWIRQDFSKVVPPLDEDGRDLLAQMLQYDSNKRISAKVALTHPFFRDVSRPTPHLI UniProtKB

Genomic	tropicalis
Genome Browser	Xenbase	Xenbase JGI Ensembl UCSC	Xenbase

Synteny	Metazome

Expression	tropicalis	laevis
UniGene	Str.2871 [+] Str.47729	Xl.4227
Unigene EST Profile	EST Profile	EST Profile
GEO data		GEO
Images	1 expression image(s) for tropicalis and laevis

Orthology	MOD	Entrez Gene	Genetic Phenotypes	Morphants
human	OMIM:Gene, HGNC	CDK2
mouse	MGI	Cdk2	All(8) Targeted, knock Out(3) Gene Trapped(1) Targeted, other(1)
zebrafish	ZFIN	cdk2

Publications
First:		Cloning by differential screening of a Xenopus cDNA coding for a protein highly homologous to cdc2. [Proc Natl Acad Sci U S A 1991]
Most recent:		Proteolysis of Xenopus Cip-type CDK inhibitor, p16Xic2, is regulated by PCNA binding and CDK2 phosphorylation. [Cell Div 2013]
		View All Papers 4 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		ATP binding cAMP-dependent protein kinase activity cAMP-dependent protein kinase regulator activity More[+] protein kinase CK2 activity protein kinase CK2 regulator activity protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity
Biological:		protein amino acid phosphorylation
Cellular Component:		cAMP-dependent protein kinase complex protein kinase CK2 complex
EC:		now divided into EC:2.7.11.1, EC:2.7.11.8, EC:2.7.11.9, EC:2.7.11.10, EC:2.7.11.11, EC:2.7.11.12, EC:2.7.11.13, EC:2.7.11.21, EC:2.7.11.22, EC:2.7.11.24, EC:2.7.11.25, EC:2.7.11.30 and EC:2.7.12.1
KOG:		[R] Protein kinase PCTAIRE and related kinases

Reagents	tropicalis	laevis
Clones		EXRC - 4 clone(s)
	open biosystems	open biosystems
	geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0	Str.2871.1.S1_at [+] Str.47729.1.A1_at	Xl.4227.1.S1_at
Affymetrix 2.0		Xl2.4227.1.S1_at

Symbol legend[+]