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Summary Expression Gene Literature (1) GO Terms (11) Nucleotides (102) Proteins (30) Interactants (52) Wiki
XB-GENEPAGE-1003599
Gene Symbol:
top3a

Gene Name:
DNA topoisomerase III alpha

Synonyms:
xtop3a ( Add synonyms , Nomenclature history )

Gene Function:
DNA topological change

Protein Function :
Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription b...[+]



Interactants:
Loading ...

Diseases: 


OMIM:
MICROCEPHALY, GROWTH RESTRICTION, AND INCREASED SISTER CHROMATID EXCHANGE 2; MGR [+]

External Links:
 
Xenbase Gene ID XB-GENE-1003600 XB-GENE-1003603 XB-GENE-17340766
Gene Symbol top3a top3a.L top3a.S
Chromosome Chr09 chr9_10L
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2
CDS Gene model Gene model
Entrez Gene 100135734
444125
mRNA NCBI Nucleotide RefSeq
Protein NCBI Protein NCBI Protein RefSeq  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine top3a top3a.L top3a.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards TOP3A OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Top3a MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Top3a Ensembl
zebrafish
ZFIN, AGR top3a ZFIN Ensembl
chicken
GEISHA TOP3A Ensembl
fruit fly
worm
Publications
First FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery., Nucleic Acids Res 2013                    
Most Recent
All View All Papers
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 11 terms 5 terms 0 term
PANTHER top3a
KEGG Pathways K03165 K03165
KOG [L] DNA topoisomerase III alpha
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks top3a
ORFs top3a.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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