Gene Symbol: apex2 Gene Name: APEX nuclease (apurinic/apyrimidinic endonuclease) 2 Synonyms: ape2, xth2, apexl2 Add Xenopus synonyms Gene Function: DNA repair Interactants: mapt(1) , View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001006803|Xenopus (Silurana) tropicalis APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (apex2), nuclear gene encoding mitochondrial protein, mRNA GAAAAATTCGATAAAAGAGTTGTGTAGAGCCGGTGTGATGGTCTGATCCCTTACCGATCCGCCCTTGCCATATCCGGGGGCGCGGAGCCGAGCTTGCCACCGCTGGAAGCATGAAGATTGTGAGTTGGAACATCAATGGGATCCGGGCAACTCGGGTGGGACTAAAGGAGACGCTGGATTCCCTGGATGCTGATATTATCTGCCTGCAAGAGACTAAAGTCACCAGAGATCTGCTGGATGAACCTTCCGCCATAGTGGAAGGATATAACTCCTACTTCAGTTTTAGCCGTGGGCGGAGTGGTTACTCAGGGGTTGCAACATTCTGCAAGAGCAGCACAACCCCATGGGCAGCTGAGGAAGGGCTCTCCGGCATGTTGTGCAACCATACGGGTTCCATCGGCTGCTATGGAAACACAGAAGAGTTCTTAGAAGAGGAGCTGCAGTCCTTAGACCAGGAGGGCAGAGCAGTACTAACACAACACAGGATCCGAAACTGTGAGGGTAAAGAGGAAACGCTCACTGTGATCAATGTTTACTGCCCTCGCGCTGACCCAGAAAAGCCAGAGCGGAAGACCTACAAACTGCGCTTCTATCGCCTGCTGCAAACGCGTGCTGAGGCCATTTTGCAGAAAGGCGGACATGTGATTATCTTGGGAGACGTTAACACTTCCCACAGGCCTCTCGATCACTGTGATCCGACAGATTTGGAAACCTTTGAGGAGAATCCCGGTCGCCAGTGGCTTAATCAGTTCCTGGGCGATCCTGTCCCATCCCAAAAGGGAGATTCAGAAACAGGCACACCACCTAGTGGTGGATCTGGGCGCTTCTATGACAGTTTCCGATACTTCCACCCTACACAGAGGAACGCCTTCACGTGCTGGTGTTCCGCTTCTGGGGCTAGGCAGACTAATTATGGCACTCGTATTGATTACATCCTGGGAAACAGTGAGCTAGTGGAGAGAGAATTTCTGGATTCAATAATAATGCCAGAGGTGGAAGGGTCAGACCACTGTCCGGTTAAAGCTGTTATGAAATGCAGGCCTATAGCAGCTAACAAATGTCCACCTTTGTGCACCAAGTATCTGCCTGAGTTTGCTGGCCGACAGCAGAAGTTATTGCAGTTTCTGATGAAAAAGGAGAACACTTCAGGCAACGCAACAGAGGAAAGCTCAGAGCTGCTGGGCTCTCAATCATCTGCAGAAGGAGCTGAGATCAGTACTGTACGCAAGCGGGGCTCTGATAAACTGAATGGCACTTCAAGGAAAAAGAACAAAATGGGGACAAATATTGGTCAAGGCAGCCTCCTGAGCTTCTTTAAGCCAGATGGGCAGAAATTAACTGTGGCACCAGAGCACAATCCCAGTGATGTGTCCATTTGTAAAAAGGAGGATACAATGCCCAAAGAATATAAAACCGCTCCTTCTGCAGTTAAATATAACCAGCCACAGGCTGCCTTTTGGAAATCCTTGCTCAAGGGCCCCCCTCCCCCACCCAACTGTAAGGGCCATGGTGAACCCTGTGTTCTGCGGACGGTAAAAAAGGCCGGTCCTAACTGTGGACGCCAGTTTTATGTCTGTGCCCGGCCTGAGGGTCATTCAACAAACCCCCAGGCCAGATGTAACTTTTTCCTCTGGCTCACCAAAAAAGCTGGAGGTGAGGACTGATATTCTCCATGCCAAGAATCCTGGTGTCAGACTTACTGGCTCTTTATGCCCCGTAGTTTATTCTTCATTCCAACAGAATGGGGGGGTATGTACCCCAGCTGTGTTGTTAATGTGCACTGGAACTAAATTTAGTAACCCCAGCCCCTGAGAATAACATCTCAGTTGCTATCAAATAATATCTGTAGCATTTATACATGTTGGTCGTTGTTCTGTGTTTGTGTCTCTGCTGTGACATTCGGCCCAGACCTTTGTTACCTCAATCAGAAAAAAACAAAAACTGTAAAGCTCTTGTATTTATAGAAATGGCAATTTTTTTAAACCGTTTTCTGCAATAAATTTTTTTCTAATTCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001093310|Xenopus laevis APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (apex2), nuclear gene encoding mitochondrial protein, mRNA CGGCAAGTTGGAACGAGTAGAGCAGTGGCGGTGTCATGCTCTGATCCCTTACAGATTCCTCCTTGTTATGTTCCAGGTCGCGGAGCCGAGCTGTAGTGTCACAGCTGGAAGGATGAAGATTGTGAGCTGGAACATCAATGGGATCCGGGCAACTCGGGTGGGTCTGAAGGAGACGCTGGATTCCCTGGATGCTGATATTATCTGTTTGCAAGAGACTAAAGTCACCAGGGACCTGCTGGACGAACCTTCGGCCATTGTGGAAGGCTATAACTCCTACTTCAGTTTCAGCCGTGTACGGAGTGGTTACTCAGGGGTCGCAACATTCTGCAAGAGCAGCACAACCCCACAGGCAGCAGAGGAAGGGCTATCTGGAGTTTTCTGCAACCGTACGGGTTCCGTTGGCTGCTATGGAAACACCGAACAGTTCTTAGAAGAAGAGCTGCAGTCCTTAGACCAGGAGGGTAGAGCAGTACTGACACAACACAGGATCTTAAACTGCGAGGATAAAGAGGAAACGCTCACTGTCATCAATGTTTACTGCCCTCGTGCCGACCCTGAGAAACCAGAGAGGAAGACCTACAAGCTGCGCTTCTATCACCTGCTGCAAACACGTGCTGAGGCCATTTTGCAGAATGGCGGACATGTCATTATCTTGGGAGACGTTAACACTTCCCACAGACCCCTCGATCATTGTGATCCGACGGATTTGGAAACCTTTGAGGAGAATCCAGGACGCCAGTGGCTTAATCAGTTCCTGGGTGATCCCATCCCATCCCAAAAGGGAGATTCAGAAACGGTGATGCCGCCTAGTGCAGGATCTGGGCTTTTCTATGACAGTTTCCGATACTTCCATCCCACCCAGAAAAACGCATTCACTTGCTGGTGCTCGGCCTCTGGGGCCAGACAGACCAATTATGGCACTCGCATTGATTACATTCTGGGAAACCGGGAGCTAGTGGAAAGTGAATTTCTGGATTCAGTAATCATGCCAGAGGTGGAAGGGTCAGACCACTGTCCAGTTAAGGCTTTTATGAAATGCCAGCCTATAGCTGCTAACAAGTGTCCCCCACTGTGCACCAAGTATCTGCCTGAGTTTGCTGGCCGACAGCAGAAGTTATTGCAGTTTCTGGTGAAAAAGGAGAACACTTTAGGGAACACAACAGAGGAAAGCTCAGAGCTGACTGGCACTCCGTCGTTTACAGAAGGAGCTGACATCAGTACTGTACGGAAGCGGCCGTCAGATAAACTGAACAGTACCTCAAAGAAAAAGAGCAAAATCGTGACAAAGAATGGGCAAGGCAACCTCCTGAGCTTCTTTAAACCAGAAAGGCAGAAATTAACTATGGCCACAGAGTGTAATCCCATTGAAGTGCCCATTTGTAAAAAGGAGAAAACTGTCCAAAAAGATTTACAACCTGCTACTCCTGCAGTTAAATATAACAAGCCTCAGACTGCCTTTTGGAAATCCTTGCTCAAGGGCCCCCCTCCACCTCCTAACTGTAAGGGCCACAGTGAACCCTGCGTCCTGCGGACTGTAAAAAAGGCTGGTCCTAACTGTGGACGTCAGTTTTATGTCTGCGCCCGGCCTGAAGGTCATTCATCAAATCCCCAGGCTCGGTGTAACTTCTTTCTCTGGCTCACCAAAAAAGCTGGATGTGAGGACTGATCTTTTCCATGCCAAGAATCCTGAAGTCAGGCTTACTGGCTCTTAATGACCAGTAGTCTGTTTGGTGCTTTGTTCGAACAGGTTATGTACCCCAGCAGTGTTGTTAATATCCATTGGCACTAAATCTAGTAACCCAGGCCTATGAGAATAACCTCATTTGTCACTGAATTCAATTTGCAGCACTTATATATGTTTGTCCTTGTTCTGTCTGTGTCTTTGCTATGAGATTTGGTCCAACCCACTTTTACCTCAATAAGAAAAACAAAAAACTGTAAATCTCTTGTATTTTGTACCAGTCGTCTGCAATAAAATGATGTTCTTTCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001006804|APEX nuclease (apurinic/apyrimidinic endonuclease) 2 [Xenopus (Silurana) tropicalis] MKIVSWNINGIRATRVGLKETLDSLDADIICLQETKVTRDLLDEPSAIVEGYNSYFSFSRGRSGYSGVATFCKSSTTPWAAEEGLSGMLCNHTGSIGCYGNTEEFLEEELQSLDQEGRAVLTQHRIRNCEGKEETLTVINVYCPRADPEKPERKTYKLRFYRLLQTRAEAILQKGGHVIILGDVNTSHRPLDHCDPTDLETFEENPGRQWLNQFLGDPVPSQKGDSETGTPPSGGSGRFYDSFRYFHPTQRNAFTCWCSASGARQTNYGTRIDYILGNSELVEREFLDSIIMPEVEGSDHCPVKAVMKCRPIAANKCPPLCTKYLPEFAGRQQKLLQFLMKKENTSGNATEESSELLGSQSSAEGAEISTVRKRGSDKLNGTSRKKNKMGTNIGQGSLLSFFKPDGQKLTVAPEHNPSDVSICKKEDTMPKEYKTAPSAVKYNQPQAAFWKSLLKGPPPPPNCKGHGEPCVLRTVKKAGPNCGRQFYVCARPEGHSTNPQARCNFFLWLTKKAGGED	Refseq >NP_001086779|APEX nuclease (apurinic/apyrimidinic endonuclease) 2 [Xenopus laevis] MKIVSWNINGIRATRVGLKETLDSLDADIICLQETKVTRDLLDEPSAIVEGYNSYFSFSRVRSGYSGVATFCKSSTTPQAAEEGLSGVFCNRTGSVGCYGNTEQFLEEELQSLDQEGRAVLTQHRILNCEDKEETLTVINVYCPRADPEKPERKTYKLRFYHLLQTRAEAILQNGGHVIILGDVNTSHRPLDHCDPTDLETFEENPGRQWLNQFLGDPIPSQKGDSETVMPPSAGSGLFYDSFRYFHPTQKNAFTCWCSASGARQTNYGTRIDYILGNRELVESEFLDSVIMPEVEGSDHCPVKAFMKCQPIAANKCPPLCTKYLPEFAGRQQKLLQFLVKKENTLGNTTEESSELTGTPSFTEGADISTVRKRPSDKLNSTSKKKSKIVTKNGQGNLLSFFKPERQKLTMATECNPIEVPICKKEKTVQKDLQPATPAVKYNKPQTAFWKSLLKGPPPPPNCKGHSEPCVLRTVKKAGPNCGRQFYVCARPEGHSSNPQARCNFFLWLTKKAGCED

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.3624 [+] Str.29182	Xl.6497
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		7 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human			APEX2
mouse		MGI	Apex2	All(5) Targeted, knock Out(2) Targeted, other(2)
zebrafish		ZFIN	apex2

Publications
First:		Subtraction scanning acoustic microscopy reveals motility domains in cells in vitro. [Cell Motil Cytoskeleton 1994]
Most recent:		How DASPMI reveals mitochondrial membrane potential: fluorescence decay kinetics and steady-state anisotropy in living cells. [Biophys J 2008]
		View All Papers

Functional Ontologies
GO: Molecular:		DNA-(apurinic or apyrimidinic site) lyase activity endonuclease activity nuclease activity More[+] zinc ion binding
Biological:		DNA repair
Cellular Component:
EC:		DNA-(apurinic or apyrimidinic site) lyase
KOG:		[L] Apurinic/apyrimidinic endonuclease and related enzymes

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.3624.1.S1_at [+] Str.29182.1.A1_at	Xl.24861.1.A1_s_at
Affymetrix 2.0			Xl2.6497.1.S1_at

Symbol legend[+]

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   - Literature Or Expression Images