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Summary Expression Gene Literature (5) GO Terms (9) Nucleotides (98) Proteins (26) Interactants (19) Wiki
XB-GENEPAGE- 1012053

Gene Symbol: apex2

Gene Name: apurinic/apyrimidinic endodeoxyribonuclease 2

Synonyms: ape2 , xth2 , apexl2
Add Xenopus synonyms , Nomenclature history


Gene Function: DNA repair

Protein Function:
Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate a...[+]


Interactants: Loading ...

OMIM Disease Associations:
 
Xenbase Gene ID XB-GENE-1012054 XB-GENE-1012061 XB-GENE-17335121
Gene Symbol apex2 apex2.L apex2.S
Chromosome Chr08 Scaffold50
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 8.0 JBrowse 8.0 GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq TrEMBL Refseq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.3624 [+] Xl.6497
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 7 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine apex2 apex2.L apex2.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
APEX2 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Apex2 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN apex2 ZFIN Ensembl
chicken
fruit fly
worm
WORMBASE
Publications
First: Subtraction scanning acoustic microscopy reveals motility domains in cells in vitro. [Cell Motil Cytoskeleton 1994]
Most recent: APE2 Zf-GRF facilitates 3''-5'' resection of DNA damage following oxidative stress. [Proc Natl Acad Sci U S A 2017]
View All Papers
Functional Ontologies tropicalis laevis.L laevis.S
GO 9 terms 9 terms 0 term
EC DNA-(apurinic or apyrimidinic site) lyase
PANTHER apex2
KEGG Pathways K10772 K10772
KOG [L] Apurinic/apyrimidinic endonuclease and related enzymes
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
ORF apex2 ORF1
Affymetrix 1.0 Str.3624.1.S1_at [+] Xl.24861.1.A1_s_at
Affymetrix 2.0 Xl2.6497.1.S1_at

Symbol legend[+]

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