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Summary Expression Gene Literature (4) Nucleotides (98) Proteins (26) Interactants (7) Wiki
XB-GENEPAGE-1012053

Gene Symbol: apex2

Gene Name: APEX nuclease (apurinic/apyrimidinic endonuclease) 2

Synonyms: ape2, xth2, apexl2
Add Xenopus synonyms , Nomenclature history


Gene Function: DNA repair

Interactants: actl6a(1) , atm(1) , atr(1) , atrip(1) , chek1(1) , clspn(1) , mapt(1) View All

OMIM Disease Associations:
 
Xenbase Gene ID XB-GENE-1012054 XB-GENE-1012061
Gene Symbol apex2 apex2
Molecules tropicalis laevis
Gene GBrowse 8.0 GBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq Refseq
Genomic tropicalis laevis
Genome Browser
GBrowse
tropicalis genome v8.0 gene model
GBrowse
laevis genome v7.2 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis
Ensembl Ensembl
UniGene Str.3624 [+] Xl.6497
RNA-seq profile: Owens, Blitz et al. 2016 apex2
Images 7 expression image(s) for tropicalis and laevis
Data Mining
XenMine apex2 apex2
Phenotype tropicalis laevis
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
APEX2 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Apex2 MGI, IMPC Ensembl, Eurexpress, MGI
zebrafish
ZFIN apex2 ZFIN Ensembl
chicken
fruit fly
worm
WORMBASE
Publications
First: Subtraction scanning acoustic microscopy reveals motility domains in cells in vitro. [Cell Motil Cytoskeleton 1994]
Most recent: APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress. [Proc Natl Acad Sci U S A 2013]
View All Papers
Functional Ontologies
GO: Molecular: DNA-(apurinic or apyrimidinic site) lyase activity   endonuclease activity   nuclease activity   More[+] PANTHER
      Biological: DNA repair   PANTHER
      Cellular Component: PANTHER
EC: DNA-(apurinic or apyrimidinic site) lyase
KOG: [L] Apurinic/apyrimidinic endonuclease and related enzymes
Reagents tropicalis laevis
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
geneservice/RZPD imagenes geneservice/RZPD imagenes
ORF apex2 ORF1
Affymetrix 1.0 Str.3624.1.S1_at [+] Xl.24861.1.A1_s_at
Affymetrix 2.0 Xl2.6497.1.S1_at

Symbol legend[+]

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