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Summary Expression Gene Literature (9) GO Terms (27) Nucleotides (130) Proteins (53) Interactants (77) Wiki
XB-GENEPAGE-1017104
Gene Symbol:
dyrk1a

Gene Name:
dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

Synonyms:
mnb ( Add synonyms , Nomenclature history )

Gene Function:
Dual-specificity tyrosine-phosphorylation regulated kinase

Protein Function :
May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.



Interactants:
Loading ...

Diseases: 


Disease Ontology:
autosomal dominant non-syndromic intellectual disability 7

OMIM:
MENTAL RETARDATION, AUTOSOMAL DOMINANT 7; MRD7

External Links:
GEO Series :
GSE149538.
1/5
 
Xenbase Gene ID XB-GENE-1017105 XB-GENE-17333050 XB-GENE-1017110
Gene Symbol dyrk1a dyrk1a.L dyrk1a.S
Chromosome Chr2 chr2L chr2S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 779733
108707859
446302
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. NCBI Protein NCBI Protein  More.. RefSeq Swiss-Prot  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine dyrk1a dyrk1a.L dyrk1a.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards DYRK1A OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Dyrk1a MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Dyrk1a Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR dyrk1aa dyrk1ab ZFIN Ensembl
chicken
GEISHA DYRK1A Ensembl
fruit fly
worm
Publications
First The dual-specificity kinases, TOPK and DYRK1A, are critical for oocyte maturation induced by wild-type--but not by oncogenic--ras-p21 protein., Front Biosci 2007  
Most Recent Parallel in vivo analysis of large-effect autism genes implicates cortical neurogenesis and estrogen in risk and resilience., Neuron 2021  
All View All Papers 2 paper(s) referencing OMIMs 4 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 27 terms 3 terms 9 terms
PANTHER dyrk1a
KEGG Pathways K08825 K08825 K08825
KOG [R] Dual-specificity tyrosine-phosphorylation regulated kinase
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks dyrk1a
Morpholinos (on-target & off-target) dyrk1a MO1 dyrk1a MO1 dyrk1a MO1
ORFs dyrk1a ORF1 dyrk1a.S ORF1
Clones Horizon Source BioScience Horizon Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info