Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (149) GO Terms (21) Nucleotides (202) Proteins (49) Interactants (772) Wiki
Gene Symbol:

Gene Name:
mitogen-activated protein kinase 8

jnk , jnk1 , sapk1 , xJNK ( Add synonyms , Nomenclature history )

Gene Function:
serine-threonine protein kinase

Protein Function :
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulating transcriptional activity. Regulates morphogenic c...[+]

Loading ...


External Links:
Xenbase Gene ID XB-GENE-1217556 XB-GENE-1217560 XB-GENE-17339765
Gene Symbol mapk8 mapk8.L mapk8.S
Chromosome Chr07 chr7L chr7S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100170194
mRNA RefSeq RefSeq NCBI Nucleotide
Protein RefSeq RefSeq NCBI Protein
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine mapk8 mapk8.L mapk8.S
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
HGNC AGR, OMIM:Gene, GeneCards MAPK8 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
MGI, AGR Mapk8 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
RGD, AGR Mapk8 Ensembl
ZFIN, AGR ZFIN, AGR mapk8a mapk8b ZFIN Ensembl
fruit fly
First Activation of mitogen-activated protein kinase cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes., J Biol Chem 1995  
Most Recent Dehydration stress alters the mitogen-activated-protein kinase signaling and chaperone stress response in Xenopus laevis., Comp Biochem Physiol B Biochem Mol Biol 2020  
All View All Papers 31 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 17 terms 10 terms 0 term
KEGG Pathways K04440 K04440
KOG [T] Jun-N-terminal kinase (JNK)
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks mapk8
Antibodies Mapk8 Ab1 , Mapk8 Ab2 , mapk8 Ab3 Mapk8 Ab1 , Mapk8 Ab2 , mapk8 Ab3 mapk8 Ab3
Morpholinos mapk8 MO1 , mapk8 MO2 mapk8 MO1 , mapk8 MO2 mapk8 MO1 , mapk8 MO2
ORFs mapk8.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.14.0
Major funding for Xenbase is provided by grant P41 HD064556