Gene Symbol: setdb2 Gene Name: SET domain, bifurcated 2 Synonyms: clld8 Add Xenopus synonyms Gene Function: histone methyltransferase Interactants:

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >BC135302|Xenopus tropicalis SET domain, bifurcated 2, mRNA (cDNA clone MGC:121304 IMAGE:7602400), complete cds GATGAGACAGTAAAATAGATGGAGCGGAGTACCAATGCACGCCATTCAACCCTGAGTTCCTGGACACGAGAATCAAATACATTATCTGTTTTATCCAAAGATGTATCACTCGAAGATGCTAAAGAATACTGGAAAGATTGTCAAGCGGATGGAAAAGTAGACTGGATATTTGAGAAACTATTGAACAAGCTCAAGATTCTTTGGCAGAAAATAAAAGATGGATCAGCAACAAACTTAGAATATGTGAGAGCTGTGATTTTGGTTAATGAAGCAGAGCAACTAGAAGAGGACACTGAAACCCTCCACACTGATATCCAAAAGGAAAATAAAGTACAAGAAAACACAGATTGTGCACCAGAAAGAAAGGAGGACTCGTGTGCAGACCTGAATTCTGATTGTGAGACTGATGTTTCAGGTTCTGAGTGTGAGCATGAGGACCACAGCACAGTTTCACCTCCTGCCACCGGGGCGGTCTGTTTTGGAAAGCATTTATGTGGCCCATCTTGTCTCTCTGACATTAATCCATCTCTGTTGAAAAAAGAAAACCCTCTAAACCTCCCAGTGTCCTGCGACTTCCAGAGATGGCGTGTAAAGACAAATGGCTCCGAATACCCGCCACATATCCTATATAAAGCTCCATGTGGGAGAAGCCTGAGAGATTCTGATGAAGTGCATTCTTACCTCACTGAAACTGGGTGCCACTTTTTAGGTGTGGACAACTTTTCTTTCAGTACTCAGGTTCAGCTGGAGAGCCATTTATCCATCAAGCAGGAAATTGTTCAGGACTGTGATATAAGCAACGATGTTGAGTCGGTGCCAGTTTCACTCTCCAATGAAATTGATGACACAAGACCAACTAATTTCATCTACAGAAAGACCTCTTGGCCCCCAGGATACTCCATAAATAATTTTACAGACATCTTTGTTAAATGCTGCAGTTGCACTGATGGCTGCTTAGATATTTCAACTTGTTCATGCCTGCAGCTCACCGCACAAGCATTTGAGAAATTTACAGATTCATCCCTTGGTATTGGTCCCCTTGGCTATAAACACAAAAGACTTCAAGAACCCGTTCCTACTGGGTTATATGAATGTAACTTGTCATGTAAGTGTGATCGGACGTTGTGCCAGAATCGAGTTGTGCAGCACGGCCTTCAGTTGAGATTGCAGGTGTTCAAAACAGATACTAAGGGCTGGGGTGTCCGCTGTCTGGATGATGTAGACAACGGGACATTTGTTTGCATCTATGCAGGGAGAATACTAATCAGAACTGCTGATTCTTCTGTAAAAACCACACTAGAGGATTCTGTGGCATGTGGTAATGAAGCTAAAGAAGATAATGGAAGCACTTCTACTCTAATGTTAAGCAAACGGAAAAGAAAGCCTTCCCATTCAGACTCTGAAGTCACAGTTATGCATTTAACTCCCTACAGCATGCGCAGCCTGGGATTATCTGTCCATAGGCAATCAAACACACTCAGTCTAACACATCTAAGATCTGGTGGAAGAGAAATATCTTTGGAGCCGTTTAGAAGACCCAAAACCAAGACCTCCATGCTCCAAAAGCGTAGAAGGCAGCTGATTGAAGAGGGGGCATGCACAGTTCACAACAGTTCAGAAGAGGAGGGTCCAACACCCCCACAGTCACCTAAGCAGAAGTTCAATGCAGGAAGGAAAATACATAGAAATGAAAATTCCGATGAGACTGCCTCAGGGTATGTGTCAGAGGAGAGCAGCAGTTCAGTTATATCTGGGGGACATCCTTCAGAAAAACCCACATGCAGGACTAAGTCAAAGCTAAACAAAATGACTCCTCATCTATCTACCTCTCCGGAACAGACTTGTGAAGAAGACTTGCATTTCTTAGATGCCTCAAAAGAGGGGAATGTTGGAAGATTTCTAAATCACAGCTGCTGTCCTAATCTGTTTGTTCAGCATGTATTTGTGGATACACACCAAAAAAGTTTTCCATGGGTGGCATTCTTTACTAACAGTGTAGTAAAAGCTGGAACAGAACTAACCTGGGACTATAACTATGTTATTGGGACTGCACCTGATCAGGAAATCCAATGCCTGTGTGGCCAACAAACATGCAAACATAAAATTGTATGAAATATTTTTTTTCCTCTTTGATCTGGAAGCAAAACGTAGGCCATGTGTTGCTGCTTCAGAGTCGTACCAGTGATCAACAGAGAAACATTATAGGCCATTACATGCACAAGGGTTCTGCTATGATAGAGGAAAATGTTTGGCTTTTGTAATTTTATACTGTACGTGTAATATAATCCTTTTCTGAAACCACTGATATCTCAGGATATCAAAGGGTTAAGATTACTTTTGGTGTGAATGCATTTTGTTAGAACAGCGCCGCCTGCTGGTCGCTTTCCAAACATAACATAGTCAAAGAGATTGTGGAGGAAGTTGTCGGGTGAAAGCAAGAGGGCTGATCTGATGTTCTTCTGGCTAGGAAAAACATTAGAATCCTCAGATGTCTTTTCTGGACAGAGCTTCAGACCAGCCCTCTTTCTTCTCCTGACAAGTTCATCCACAACGTTCTCAACTACTTCATGTTTGGAAGGTGACAAGCAGGTGGCGCTGTTGTGATAAAATGCATTCATGTTGACAGTACTTGTAACCCTTAATATCTTGAAATAAAACAAATAAATAATGAATCTTACATGCATCTAAACTCTACAAATGAATCTCGCACATTAGCATTTACATATATTGCATACATTTTTAGCAGTTCCTGAGATATTAGCAGTTTTTGACTGGCAAAACCAGGCTTTTGGCTCACCAGCTCTCTTTGAAAATCAACCTACGGGTAACTGACTACTCAGGAAGCACAGCGCATGTTCATTTAGGGTCGCTGAGTTTGTTGAGACAAAATTGTCACTTGCTAAAGTCCTCAGAAGAGCACGTCAAGCAGTGCATAACTATAGAGGAAGCAGACCCCATTGCGGGAGGACTGGGGTCTGTGGCTGGTTCCGCTATAGCCCACTCTACTACCGTAAAATTTGCACACCTACTACAATGGACCTGGCTCCCTGTCATTACGCCGCTGAATTGGCACCTTTTCATCAATTCATATTTTGGTTTTAGTTCTTCTTTAATACATTTCTTCATATTTAATGTCAGCAAAATAATTGTGGGGCGATAACTGCACTAAAAAAAGAAAGAAAATCTAATTAAGCTTAGTTTAGCCTTTAAATGATAAAATTCCAGAGATCGAGGGTTATGTATTGGTTGCTTTGTATACTTATACAGTATCTGTATTGAATATGCGTATAATATACTACCATGTGGTTTTTGACACACAATGTTACATTCTACCTTCTTTTTGTATATTGAATCAAATCTCTCTGTATAATCTGTTATAAATTTTTAATCGTTCCAAAGATAAGAGATGTTAGCTCCAGCCTGACACCACTCATCCCCGCACTTGTGCTCTTTTGGCTACTGCTGGCTGGTAGCATTGGATCTTAGCATCAGTTTTTAGCAGTGCAAATCAAACAACATATTGTTGAATGTAACTGTTATAGAATGCAAAAAACTGGAATAGATCTAGACACTACTGTAAGGGGCAGACTTATCGAAATGTGAGTTTAGAGCTTAATACATAAAAACTCATGTTCTGTTCATTCCTATGGGATTTTTAAAAGTGTATTTATCAGTGATTAAAAGTCAGAACGCACCATTTGATAATGAATAGAACATAACCTAACTTTATATTACCAATGTAAAGGTAGTGAGTTGCATCAATAACTGCTACCAACTTGTGCTAGGCAAATTCAGATGCTGATGGCCTTATTAGAATCCTGGAAATCATGCCATTCCCACAACGTAAATATTTTTTAGCAACATTCATGCAATTTGCAAAACACCCATGCTAATGAGAATATGTATTGTTGCATTAAACAGACATTTTAGCGTATGCATATTAGTGTGCACCTACGTTGACACTGGAATTCTGGGTAAAACACAGAACTGTGGGTAAAACATGTCACTTTGCATCCAAAGATGACATTTTGCACCATGCACTGACTTCGTAAATGTCCCTAATATCTCTTCTTTAGAACTTGACAGAATTTAAAATAGATTAGACTTAGTGACCAACCCAGATAATGACAAATAAATTTAAAATGTAATTTCATGATAGTTTCTGTTTAAAGAAGGGGTTAGAGGTGCAGAGCTTGCATTCAAACATTGTAAACATCCAAGAGCAACAGAAATCTGCAATGACTTATTGTTTTATTTTGCATTGTAATAAACACACTTGTATCAACTGTTATACCTTAAGAATGCTATTTTTATAAATAATACATTATTTTTGTAAAAAAAAAAAAAAA	Refseq >NM_001089296|Xenopus laevis SET domain, bifurcated 2 (setdb2), mRNA GCACGAGGCACAAACACTGTAGCAAACTGTACGGATTCCAACCTAGGTTGGGCTTGTGTAGTGTCATGTATTTGCTGCAACATATACGTCCATTCAACTTTAACTTCCCGCCGTATGCAAATTAGACAACGTTAGCGCAACTTCGCTTGGCGCAGTAATGCTAACACAACTTCGCCAGCGTTCAGCGCCCTGGACGCAGGTTCGGATTTTAGTGAATTAACATTGTCCTGGCAAAGTGTTGTGATGTGAGTGAAGCCATCGCTGGTGAATTTTCGGAGGAGAGTGAAATAAATGGAGCAGAGTGCCAATGCTCGGCAGTCAACCCTACGTTCCCGAACACAAGAATTAAATACACTATCTGTTTTGTCCAAAGATGTATCGCTCGAAGATGCAAAGAAATATTGGAAAGATCGTCAAGCGGATGGGAAAGTAGACTGGATATTTGAGAAAGTATTGAACAAGCTCAAGATTCTTTGGCAGAAAATCAAAGATGGGTCAGCAACAAACTTAGAATATGTAAGAGCTGTGATTTTGGTGAATGAAGCAGGAAATTTAGAAGAGGACTTGGAAGAGGACTTACAAGAGGACACTGATACCATACACATTGATATTCACAAGGAAAATGAAGTGCAGGAAAACACAGATTGTTCTCCAGAAAGAAAGGAGGACACATGTCTTAACCTAAATACTGATTGTGGGACAGATGTTTCAGGTTCTGAGCCTGAGTGCAACAGCACAGTTTCGCCTCCTGCTGCAGAGAGGGTCTATTTTGGAAACCATTCATGTGGCCCATCTTGTCTCTCTGGCATTAATCCATTTCTATTTACAAAAGGAAACCCTCTACAACTCCCAATCTCCTGTGACTTTCAGAGGTGCCATCTAAAGATAAATAGCCCTGATGACCTGTCACATATCCTATATAAAGCTCCATGTGGCAGAAGCCTGAGAGACTATGATGAAGTGCATTCTTACCTCACTGAAACTGGGTGCCACTTTTTAGCTGTGGACAACTTTTCTTTCAATAATCATGTTCGGTTGGACAGCAATTCATCTTTCAACCAAGGAATTGTTCAGGACTGTGATATAAGCAACGATGTGGAGTCAGTGCCAGTTGCATTCTCCAATGAAATCGATAACACAAGACCATCTAATTTCATCTACAGAAAGACCTCTTGGCCACCAGGATACTCCTTAAATAATTTCACAGACATCTTTGTAAAATGCTGCAATTGCACTGATGGCTGCTTAGACATCTTAACTTGTTCATGCCTGCAACTCACAGCACAAGCATTCACGAAATGTATGGAATCGTCCCTCGGTATCGGTCCCCTAGGCTATAAACACAAAAGACTTCAAGAACCTATCCCTACTGGATTATATGAATGTAACGTGTCCTGCAAGTGTGATCGGATGCTGTGCCAGAATCGAGTTGTGCAGCACGGCCTTAAACTGAGACTGCAGGTCTTCAAAACAAATACTAAGGGCTGGGGTGTCCGCTGTCTGGATGATGTAGACAAAGGGACATTTGTTTGCATCTATGCAGGAAGAATACTAATCAGGACAGCAGATTGTACTGTGAAAAGCACACCAGATGATTCTGTGGCATGTGGTAATGAAGATCATGAAGATAGCACAAGTACTTGTGCTCTAATATTAAGCAAACGGAAGAGAAAGACGTCCCATTCAGACTCTGAAGTCACAGTTATGCATACAAACCCCTACAGCATGCGCAGCCATGGATTATCTGTCCATAGACTATCAAACACATTCAGTCCAAGACAGGCTAGATCTGGTGAAAGAGAATTCTCTTTGCAGCCACTTAGAAGACCCAAAACAAAGACCTCCATGCTCCAAAAGCGTAGAAGGCAGCTCATTGAAGAGGGAGCGTGCACAGTTCAGAACAGTTCGGAAGAGGAGGGTCCAACACCTCCACAATCGCCTGAGCAGAAATCCAGTGCAGGAACCAAAATACAAAGAAATGAAAATTCTGATGAGACTGCTTCAGGGTATGTGTCAGAGGAGAGCAGTAGTTCAGTTATTTCTGGGGGACATCCTTTAGAAAAACCCATATCCAAGTTTAAGTCAAAGCTAAACAAAACGACCGTGTATCTATCTACCTCTCCGGAACAGACTTGTGAAGAAAACTTGCATTTCTTAGATGCATCGAAAGAAGGGAATGTTGGACGGTTTCTAAATCACAGCTGCTGTCCCAATCTATTTGTGCAGCAAGTATTTGTGGATACACACCAGAAATGTTTTCCGTGGGTGGCATTTTTTACTAACAGTGTAGTAAAAGCTGGAACAGAACTAACCTGGGACTATAGCTATGATATTGGGACTGCTGCTGATCAGGAAATCCAATGCCTGTGTGGTCAAAAACATGCAAAATAAGTTGTATGAAATATTTCCAGCATTTCACTCTAGTACTGATGGAAGCTCACTCACTCTGCTGAAACAAATCCCTTCTACAAATGCTTTATAAATGGTGGAGTCTTACATGTAATGTATTAGGCGTTATTATAGGACATTAAGGGGCATTTTTTGCGAATGTGTTATGTAATGTCTCATGTAGGAGAGGCCTTCACTAGTAGTAGTCCTGAAAACATGGAAGACATTCCCAGTTTGAAGGGGTGATCCCTGCACGTGATGTAACTGTGGCGATTTTGACTGCTCTCTAACTTTTTCATGTTGTAGACAGGCTAGGTTATAATAAATTATGATTTTAAAAAAATCACAGTTTAGGAACACACCCAGCACTTGGCCTAGGTTGAACAGACAAAACCCAAAAAAGACATAAGTAGAAATCACTGGGAAATATGCAGAAATATTATTTTTCATGCTTGCCTTTTATTTGTCACTTGATGACCTGCAGAATAATGTAGGCCTTGTGGTGCTGCATCAGAGTTTTAGCGGTGATCTGCAGAGAGATATTAAAGACCAATCATATGTATCAAAATTGTACTATCATAGACAAATGTTTTCTTTTTATGTATAACCGTAGTCCCAACAAAGTAGGGATAGCAGTATGTTTATCCTTCAACAAGTTAATGAAAAACTTTTGTTTTAAAAAAAAAAAACAAAAAAAAACCAAAAAAAAGA
Protein		NCBI Protein >AAI35303|setdb2 protein [Xenopus (Silurana) tropicalis] MERSTNARHSTLSSWTRESNTLSVLSKDVSLEDAKEYWKDCQADGKVDWIFEKLLNKLKILWQKIKDGSATNLEYVRAVILVNEAEQLEEDTETLHTDIQKENKVQENTDCAPERKEDSCADLNSDCETDVSGSECEHEDHSTVSPPATGAVCFGKHLCGPSCLSDINPSLLKKENPLNLPVSCDFQRWRVKTNGSEYPPHILYKAPCGRSLRDSDEVHSYLTETGCHFLGVDNFSFSTQVQLESHLSIKQEIVQDCDISNDVESVPVSLSNEIDDTRPTNFIYRKTSWPPGYSINNFTDIFVKCCSCTDGCLDISTCSCLQLTAQAFEKFTDSSLGIGPLGYKHKRLQEPVPTGLYECNLSCKCDRTLCQNRVVQHGLQLRLQVFKTDTKGWGVRCLDDVDNGTFVCIYAGRILIRTADSSVKTTLEDSVACGNEAKEDNGSTSTLMLSKRKRKPSHSDSEVTVMHLTPYSMRSLGLSVHRQSNTLSLTHLRSGGREISLEPFRRPKTKTSMLQKRRRQLIEEGACTVHNSSEEEGPTPPQSPKQKFNAGRKIHRNENSDETASGYVSEESSSSVISGGHPSEKPTCRTKSKLNKMTPHLSTSPEQTCEEDLHFLDASKEGNVGRFLNHSCCPNLFVQHVFVDTHQKSFPWVAFFTNSVVKAGTELTWDYNYVIGTAPDQEIQCLCGQQTCKHKIV UniProtKB	Refseq >NP_001082765|histone-lysine N-methyltransferase SETDB2 [Xenopus laevis] MEQSANARQSTLRSRTQELNTLSVLSKDVSLEDAKKYWKDRQADGKVDWIFEKVLNKLKILWQKIKDGSATNLEYVRAVILVNEAGNLEEDLEEDLQEDTDTIHIDIHKENEVQENTDCSPERKEDTCLNLNTDCGTDVSGSEPECNSTVSPPAAERVYFGNHSCGPSCLSGINPFLFTKGNPLQLPISCDFQRCHLKINSPDDLSHILYKAPCGRSLRDYDEVHSYLTETGCHFLAVDNFSFNNHVRLDSNSSFNQGIVQDCDISNDVESVPVAFSNEIDNTRPSNFIYRKTSWPPGYSLNNFTDIFVKCCNCTDGCLDILTCSCLQLTAQAFTKCMESSLGIGPLGYKHKRLQEPIPTGLYECNVSCKCDRMLCQNRVVQHGLKLRLQVFKTNTKGWGVRCLDDVDKGTFVCIYAGRILIRTADCTVKSTPDDSVACGNEDHEDSTSTCALILSKRKRKTSHSDSEVTVMHTNPYSMRSHGLSVHRLSNTFSPRQARSGEREFSLQPLRRPKTKTSMLQKRRRQLIEEGACTVQNSSEEEGPTPPQSPEQKSSAGTKIQRNENSDETASGYVSEESSSSVISGGHPLEKPISKFKSKLNKTTVYLSTSPEQTCEENLHFLDASKEGNVGRFLNHSCCPNLFVQQVFVDTHQKCFPWVAFFTNSVVKAGTELTWDYSYDIGTAADQEIQCLCGQKHAK UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.16757	Xl.29790
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	SETDB2
mouse		MGI	Setdb2	All(2) Targeted, other(2)
zebrafish		ZFIN	setdb2

Publications
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Functional Ontologies
GO: Molecular:		DNA binding histone-lysine N-methyltransferase activity zinc ion binding
Biological:		chromatin modification
Cellular Component:		nucleus
EC:
KOG:		[B] Predicted histone methyl transferase

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.16757.1.A1_at [+] StrEns.4028.1.S1_at
Affymetrix 2.0			Xl2.29790.1.S1_at

Symbol legend[+]

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