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Summary Expression Gene Literature (31) GO Terms (41) Nucleotides (208) Proteins (47) Interactants (439) Wiki
XB-GENEPAGE-491432
Gene Symbol:
pten

Gene Name:
phosphatase and tensin homolog

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
protein tyrosine phosphatase

Protein Function :
Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase.


InterPro :
ASF1-like sf , ASF1-like , Tyr Pase cat , Tensin phosphatase [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
Bannayan-Riley-Ruvalcaba syndrome [+]

OMIM:
THYROID CANCER, NONMEDULLARY, 2; NMTC2 [+]

External Links:
1/3
 
Xenbase Gene ID XB-GENE-491433 XB-GENE-491437 XB-GENE-17342770
Gene Symbol pten pten.L pten.S
Chromosome Chr7 chr7L chr7S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100144716
399142
100505440
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More.. NCBI Protein RefSeq  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine pten pten.L pten.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards PTEN OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Pten MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Pten Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR ptenb ptena ZFIN Ensembl
chicken
GEISHA PTEN Ensembl
fruit fly
FLYBASE Pten Ensembl
worm
Publications
First Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association., Cell 1999  
Most Recent Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos., Sci Rep 2020                        
All View All Papers 1 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 36 terms 22 terms 18 terms
PANTHER pten
KEGG Pathways K01110 K01110 K01110
KOG [TR] Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks pten
Antibodies Pten Ab1 Pten Ab1
Morpholinos (on-target & off-target) pten MO1 pten MO1 pten MO1
ORFs pten.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info