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XB-GENEPAGE-491432
Gene Symbol:
pten
Gene Name: phosphatase and tensin homolog
Synonyms:
( Gene Function: protein tyrosine phosphatase Protein Function
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Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase.
Interactants:
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Diseases: Disease Ontology:
Bannayan-Riley-Ruvalcaba syndrome
OMIM:
THYROID CANCER, NONMEDULLARY, 2; NMTC2
External Links:
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Xenbase Gene ID | XB-GENE-491433 | XB-GENE-491437 | XB-GENE-17342770 | |||||
Gene Symbol | pten | pten.L | pten.S | Chromosome | Chr7 | chr7L | chr7S | |
Molecules | X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genomic Sequence |
Version 10.0
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Version 9.1
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Version 9.1
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CDS |
Gene model
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Gene model
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Gene model
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Entrez Gene |
100144716
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399142
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100505440
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mRNA |
NCBI Nucleotide
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NCBI Nucleotide
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NCBI Nucleotide
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Protein
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Genomic |
X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genome Browser (Click image to open in Genome Browser)
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Genomic Synteny | Genomicus PANTHER | |||||||
Expression | Development Stages | Embryonic Tissues | Adult Tissues | |||||
Summary for |
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More Information |
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Proteomics | X. tropicalis | X. laevis.L | X. laevis.S | |||||
Embryonic Protein Expression | Stage profile:![]() |
Stage profile:![]() |
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Data Mining | X. tropicalis | X. laevis.L | X. laevis.S | |||||
XenMine | pten | pten.L | pten.S | |||||
Orthology |
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human |
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mouse |
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rat |
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zebrafish |
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chicken |
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fruit fly |
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worm |
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Publications | ||||||||
First |
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association., Cell 1999 |
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Most Recent |
Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos., Sci Rep 2020 ![]() |
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All | View All Papers 1 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology | |||||||
Functional Ontologies | X. tropicalis | X. laevis.L | X. laevis.S | |||||
GO | 36 terms | 22 terms | 18 terms | |||||
PANTHER | pten | |||||||
KEGG Pathways | K01110 | K01110 | K01110 | |||||
KOG |
[TR] Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases
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Reagents | X. tropicalis | X. laevis.L | X. laevis.S | |||||
CRISPRscan Tracks | pten | |||||||
Antibodies | Pten Ab1 | Pten Ab1 | ||||||
Morpholinos (on-target & off-target) | pten MO1 | pten MO1 | pten MO1 | |||||
ORFs | pten.L ORF1 | |||||||
Clones | Horizon Source BioScience | Horizon Source BioScience | Horizon | |||||
Plasmids | Addgene | Addgene |
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