Gene Symbol: ace Gene Name: angiotensin I converting enzyme Synonyms: xace Add Xenopus synonyms Gene Function: protease, blood pressue regulation Interactants: slc15a1(5) , ace2(3) , ache(3) , slc15a2(3) , fgf8(2) , tmem27(2) , agxt(1) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene
mRNA		Refseq >NM_001123410|Xenopus (Silurana) tropicalis angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (ace), mRNA TATGCATCGCACAGCTGCACCTGGAGGCACCCAAACCATGAGGGTGCTTCTCCTGGGGCTCCTCCTGCTGGTGGGCACCAATTCAGCCCTGGACAGCTCCTTCCTGCCAGGCACCTACCCCAAGGATGAGGCTGGTGCCAGAGACTTTGCCGATGCCTACAACAGCACAGCAGAGGTTATCCTATTCAAGAGTGTGGAAGCCAGTTGGGCATATAACACCAACCTGACTGACTACAACTCCAAGCAGCAGATTCTAGCTTCCATGGAGGAGCAGGAGTTTAATGAGGCATGGGGTATGAAGGCTAAGGAACTTTTCAATGATGTGTGGGAAAACTTTACAGATCCATTACTCAAGAAAATTATCAGTTCTATAAGGACCCTCGGAGCATCAAACTTGAACTTGACTGCAAGAGAGGAGTATAACACCATTCTAAGCGAGATGGACAGCATCTATTCAACAGCCAAAGTTTGCCCTCCCAATGCAACTGCGAAATGCTGGTCTTTGGAACCCGAAATAACAGAGATCATGGCAACATCCAGGAGTTACAAGAAGCTTCTCTATGCCTGGGAAGGCTGGCATAACTCTGCAGGGATTCCACTAAAGGAGAAATACTTACGATTTGTGCAGCTCAGTAATGAAGCTTACAGGATGGACGGATATAAGGACACTGGTGCCTACTGGCGCTCTTGGTATGCATCTCCCACATTTGAAGAGGACCTGGATGGCCTATACCAACAACTAGAACCTCTATACCTCAATCTACATGCCTTTGTACGCAGGAAACTGTACGAGCGCTATGGGGCTAAATATATCAACTTGAAAGGACCAATTCCAGCTCATCTGTTTGGTAACATGTGGTCCCAGCAGTGGAATAATATCTACGACATGATGATTCCCTTCCCAGACAAGACCAATATAGATGTCACTAATACAATGAGGGAAAAGGGATGGAATGCTACCCATATGTTCAGAGTTTCAGAGGAGTTCTTCACCTCCCTGGGTCTGCTGGAGATGCCCCCAGAGTTTTGGGAAAAGTCAATGTTGGAAAAACCAGCAGATGGACGTGAGGTGGTGTGTCATGCATCTGCATGGGACTTCTACAACCGTAAGGACTTCCGGATAAAGCAATGCACTACAGTCACTATGGAGCAGCTCTTCACTGTGCACCATGAGATGGGCCACGTGGAGTATTACCTGCAGTATAAGGATCAGCCGGTCACATACCGCCGGGGGGCAAACCCAGGCTTCCATGAGGCCATAGGAGATGTGCTCTCCCTTTCAGTCTCAACCCCAGGACACCTGAAAACAATTGGGCTTCTTGAAACTGTCACTAATGATAAAGAAAGTGATATCAATTATCTGTTGAAAATGGCTCTGGAGAAAATTGCCTTCCTGCCATTTGGCTTCCTGATTGATCAGTGGAGATGGAATGTCTTCAGTGGCCGCACACCTCCCACCAGATACAACTACGACTGGTGGAACCTTCGAACAAAATATCAAGGTATCTGCCCACCAATCTCAAGAGATGATAACCAATTTGATGCTGGGGCAAAGTATCATATTCCAGGCAACACACCTTACATCAGGTACTTTGTGAGTTTTGTGCTGCAGTTCCAGTTCCATAAGGCTCTCTGTACAGCAGCCAAACATACAGGTCCCCTGCATACATGTGATATTTACAGATCCCAGGAGGCTGGAAAAATTCTTGGAGATGTTCTCCGGTCAGGATCCTCCAAGTCTTGGCAGGAGGTTCTGAAGGACATGACAGGTAGTGAAAAGATGGATGTTGGGCCCTTGCTTGAATACTTCACCCCTGTCACACAGTGGCTGATTGAGCAAAACACCAAAAATAACGAGATTCTCGGCTGGCCGGATTTTTCATGGACGCCTCCAATGCCCGATGGATATCCAGGAGATATTGAAAAAATTGCAAATGAGAAAGAAGCTGATACTTTCCTGTCCGATTATACCAAGTCAGCAGAGGTGGTGTGGAACGATTATACTGAGGCATCATGGGCCTATAACACAAACATCACTGAGGCCAACAAGCAAGTTATGCTGGACAAAAACCTGGCCATGTCGGGACACACCTTACAATATGGGCTGCAGGCAAGAAACTACGATTACAGTGATTTCCAGGACCCTGAGACACAGCGCATTCTGAGGAAACTCAGTGAGATCGATAAAGCTGCTCTTTCAGAGGAGGAACAGAAAGAGTACAATCAAATCACATCCGACATGGAGACTATTTATAGTGTGGCCAAAGTTTGCAAGGATGGTAACACAAACTGCCATCCTCTTGATCCAGACCTAACAGAGATCTTGGCCAAGTCTCGGGACTATGATGAGCTTCTGTTTGCTTGGAAAGGGTGGAGAGATGCTTCAGGCAAACAAATCCGTGAAAAATACAAGAGATATGTACAATTGGCCAACAAAGCTGCACAGCTCAATGGTTACAATGACAATGGAGCATACTGGAGATCTTGGTATGAGACCCCAACACTTGAATCAGATGTTGAGAAACTTTATGACGAGTTGCAGCCTCTCTACCTCAATTTGCATGCATATGTGCGCAGGGCTCTTTACAAGAAGTATGGAGATAAAAGAATCAACCTAAAGGGGCCAATTCCTGCTCATCTCTTGGGTAACATGTGGGCACAGTCCTGGTCTAACATTTATGAGTTGTTGGTTCCATATCCCAATGCTGCACAAGTGGATGCTACTCCAGCCATGATTGCTAAGAATTGGACTCCAAAAAGGATGTTTGAGGAATCTGACAACTTCTTCAAGTCTCTGGGGCTTCTCCCAATGCCACAGGAATTCTGGGATAAATCCATGATCGAGAAGCCTAAAGACAGAGAGGTAGTGTGCCATGCATCTGCTTGGGACTTCTACAACCGCAAAGATTTCAGGATTAAACAGTGCACAGTGGTAAACATGGACGACCTAATCACAGTCCACCATGAGATGGGGCACGTTCAATATTTCCTTCAGTACAAGGATCAGCCTATCTTGTTCCGTGAGGGAGCCAACCCAGGTTTCCATGAGGCAATTGGGGATGTGCTTGCTCTTTCAGTCTCTACACCAAAACACTTGCAAAGCATTGGCCTTTTGGATAAGGTGGAGGACAACCCAGAAAGTGATATTAATTATCTCATGAGTATTGCACTGGATAAAATTGCCTTCCTTCCATTTGGTTTCCTCATGGATCAGTGGCGCTGGAAGGTGTTTGATGGAAGAACACCAGATTCAGAATACAACCAACAGTGGTGGAACCTCAGGTTGAAGTATCAGGGCCTTGTTCCTCCAGTACTAAGGACTGAAAACGATTTTGATCCAGGTGCTAAATTCCACATTCCAGCCAGCGTACCCTACATCAGGTACTTCATCAGTTTTGTCATCCAGTTCCAGTTTCATGAAGCTCTTTGTAAAGCAGCAAATCAGGAAGGACCTCTGCACAAATGTGACATCTACCAATCCACGCAGGCTGGAAAACTGCTCGGAGATGCCATGAAGTTGGGAAACAGCAAACCTTGGCCAGAAGCTATGCAAACAATTACTGGACAAAGGAACATGTCTGCTCATGCCCTTCTCAAATACTTCCAGCCCCTGACTGACTGGCTTATCAAGGAGAATACAAAGAATGGCGAAACCTTAGGATGGCCAGAATACAACTGGAGCCCAGTACAATCCGTTCCTCTGCCACCGTCTGGAGATTCTAACTCTGACTTCTTGGGACTGGCGGTTAGCAATAGCCAAGCAGCTGCTGGACAATGGATTCTCCTGGCTTTGGGCATTGTCCTCATCATCACCACCATTGTCTTTGGTGTGCTATACTCAAAAATGAAAAGCAGAGCTAAGATGTCCAGCTCTCAGATGGAGCTGAAATAGACAAAGATATCACTGATTGCAAGTGTATGCTTCTCAGTGGTAGGGACCACTTCCAGCATTCCAAAACTTGTGGACACGTAGTGTGTGCGTTCCATCAGGGCAAAATTTTTTTTGACTATGCAAAGAATTTAATCCATGGGAAATAAATCCACTTGCGCCTTTAATGCTATGATTAAAAGGATGTACTGTTCTACAGGTGCTGTTGGGATCCGAGGGGAGGGTAAGGGGTTTATTGGTTGAGATTCTATTTAAATAAATGGATCACAGGAAGCAAGATCTGTTCAGATCTTTTCTCCAGCAACAGGAGCAATAAATTGTGTTGTGAAAAAAAAAAAAAAA
Protein		Refseq >NP_001116882|angiotensin I converting enzyme 1 precursor [Xenopus (Silurana) tropicalis] MRVLLLGLLLLVGTNSALDSSFLPGTYPKDEAGARDFADAYNSTAEVILFKSVEASWAYNTNLTDYNSKQQILASMEEQEFNEAWGMKAKELFNDVWENFTDPLLKKIISSIRTLGASNLNLTAREEYNTILSEMDSIYSTAKVCPPNATAKCWSLEPEITEIMATSRSYKKLLYAWEGWHNSAGIPLKEKYLRFVQLSNEAYRMDGYKDTGAYWRSWYASPTFEEDLDGLYQQLEPLYLNLHAFVRRKLYERYGAKYINLKGPIPAHLFGNMWSQQWNNIYDMMIPFPDKTNIDVTNTMREKGWNATHMFRVSEEFFTSLGLLEMPPEFWEKSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTTVTMEQLFTVHHEMGHVEYYLQYKDQPVTYRRGANPGFHEAIGDVLSLSVSTPGHLKTIGLLETVTNDKESDINYLLKMALEKIAFLPFGFLIDQWRWNVFSGRTPPTRYNYDWWNLRTKYQGICPPISRDDNQFDAGAKYHIPGNTPYIRYFVSFVLQFQFHKALCTAAKHTGPLHTCDIYRSQEAGKILGDVLRSGSSKSWQEVLKDMTGSEKMDVGPLLEYFTPVTQWLIEQNTKNNEILGWPDFSWTPPMPDGYPGDIEKIANEKEADTFLSDYTKSAEVVWNDYTEASWAYNTNITEANKQVMLDKNLAMSGHTLQYGLQARNYDYSDFQDPETQRILRKLSEIDKAALSEEEQKEYNQITSDMETIYSVAKVCKDGNTNCHPLDPDLTEILAKSRDYDELLFAWKGWRDASGKQIREKYKRYVQLANKAAQLNGYNDNGAYWRSWYETPTLESDVEKLYDELQPLYLNLHAYVRRALYKKYGDKRINLKGPIPAHLLGNMWAQSWSNIYELLVPYPNAAQVDATPAMIAKNWTPKRMFEESDNFFKSLGLLPMPQEFWDKSMIEKPKDREVVCHASAWDFYNRKDFRIKQCTVVNMDDLITVHHEMGHVQYFLQYKDQPILFREGANPGFHEAIGDVLALSVSTPKHLQSIGLLDKVEDNPESDINYLMSIALDKIAFLPFGFLMDQWRWKVFDGRTPDSEYNQQWWNLRLKYQGLVPPVLRTENDFDPGAKFHIPASVPYIRYFISFVIQFQFHEALCKAANQEGPLHKCDIYQSTQAGKLLGDAMKLGNSKPWPEAMQTITGQRNMSAHALLKYFQPLTDWLIKENTKNGETLGWPEYNWSPVQSVPLPPSGDSNSDFLGLAVSNSQAAAGQWILLALGIVLIITTIVFGVLYSKMKSRAKMSSSQMELK

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.34053	Xl.48527 [+] Xl.56430
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	ACE	OMIM:267430 OMIM:104300 OMIM:603933
mouse		MGI	Ace	All(16) Targeted, knock Out(6) Targeted, other(8)
zebrafish

Publications
First:		Expression of acetylcholinesterase gene(s) in the human brain: molecular cloning evidence for cross-homologous sequences. [J Physiol (Paris) 1985]
Most recent:		Intestinal absorption mechanism of tebipenem pivoxil, a novel oral carbapenem: involvement of human OATP family in apical membrane transport. [Mol Pharm 2010]
		View All Papers

Functional Ontologies
GO: Molecular:		metallopeptidase activity peptidyl-dipeptidase A activity zinc ion binding
Biological:		proteolysis
Cellular Component:		membrane
EC:		peptidyl-dipeptidase A
KOG:		[E] Angiotensin I-converting enzymes - M2 family peptidases

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.5776.1.S1_at
Affymetrix 2.0			Xl2.48527.1.S1_at [+] Xl2.56430.1.S1_at

Symbol legend[+]

- Blast this sequence
   - Literature Or Expression Images