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Summary Expression Gene Literature (23) GO Terms (21) Nucleotides (142) Proteins (40) Interactants (351) Wiki
XB-GENEPAGE-480617
Gene Symbol:
irx2

Gene Name:
iroquois homeobox 2

Synonyms:
mgc89388 , Xiro2 , Iro2 ( Add synonyms , Nomenclature history )

Gene Function:
homeodomain transcription factor

Protein Function :
Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in neural...[+]



Interactants:
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Diseases: 


External Links:
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Xenbase Gene ID XB-GENE-480618 XB-GENE-865393 XB-GENE-17342313
Gene Symbol irx2 irx2.L irx2.S
Chromosome Chr6 chr6L chr6S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 493475
378497
108720018
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More.. NCBI Protein
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine irx2 irx2.L irx2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards IRX2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Irx2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Irx2 Ensembl
zebrafish
ZFIN, AGR irx2a ZFIN Ensembl
chicken
GEISHA IRX2 Ensembl
fruit fly
worm
Publications
First Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate., EMBO J 1998  
Most Recent A catalog of Xenopus tropicalis transcription factors and their regional expression in the early gastrula stage embryo., Dev Biol 2017          
All View All Papers 5 paper(s) referencing morpholinos
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 17 terms 15 terms 7 terms
PANTHER irx2
KEGG Pathways
KOG [K] Transcription factor EMX1 and related HOX domain proteins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks irx2
Morpholinos (on-target & off-target) Irx2 MO3 , irx2 MO1 Irx2 MO4 , Irx2 MO3 , irx2 MO1 , irx2 MO5 irx2 MO1
ORFs irx2 ORF1 irx2.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

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