Gene Symbol: ptgs2 Gene Name: prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Synonyms: cox2, cox-2, phs-2, pgg/hs, pghs-2, gripghs Add Xenopus synonyms Gene Function: peroxidase/oxygenase Interactants: cox1(3) , abcc8(1) , ahr(1) , aif1l(1) , ankrd37(1) , arl5b(1) , asb5(1) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001030526|Xenopus (Silurana) tropicalis prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (ptgs2), mRNA GCGATCCCAGCAACGGGTTATCAGCAGCAGTAGCAGAAGTAGTAGTAAAAAAAAGTAGTAGAAGTAGTAGTATAGCCGCAGTAGTAGTGGGATAGAGAAGGTACATACCGCACAGCCCGCCTGCGCTACTCGCTCTCCATTGGAATGATCGTACTACCCGCCGCTGTGTTCCTCTCTCTGCTGGTTTTCTCTCAAGCAGCAAACCCATGCTGTTCAAATCCCTGCCAAAACCGGGGGGTATGCATGACTGTTGGCCACGACCGCTATGAATGTGACTGCACAAGAACAGGCTTCTATGGAGAAAACTGCACTAAACCGGAATTCCTATCGTGGTTGAGGCTGAAGCTGAAGCCAGCCCCCAACACAGTGCACTATATCCTGACACACTTCAAAGGACTATGGAATATAGTGAACAATATTTCCTTCCTGAGGGATGCCATTATGCGATATGTCCTGACATCCCGATCGCACCTGATTGACAGCCCACCCACGTATAACAGCCACTATGGATATAAAAGCTGGGAGGCATTCTCCAATCTGTCCTATTATACTCGTACCTTGCCTCCTGTGGAACGTGACTGCCCTACCCCAATGGGAGTTAAAGGAATGAAAGAGCTTCCAAGTGCAAAGTTGGTAGTGGAGAAATTCCTGATGCGAAGAAAATTTATTCCTGACCCTCAAGGCTCCAATGTTATGTTTGCTTTTTTTGCTCAACACTTCACACACCAGTTCTTCAGAACAGATATGGCCAAAGGGGCTGCCTTCACCAAAGCATTGGGCCATGGGGTTGATCTCAATCATATCTATGGTGAAAGCTTAGAAAGGCAACATAAACTGCGTTTAATGAAAGGTGGCAAACTGAAATATCAGATGATAAGTGGGGAAATGTACCCACCAACAGTGAAAACCACAGGAGTGGATATGGTGTACCCACCTCACATTCCAGATCACCTTCAGTTTGCCGTTGGGCAAGAGGTTTTTGGCCTTGTTCCAGGGCTGATGATGTACTCCACCATCTGGTTAAGGGAGCACAATCGGGTTTGCGACATACTTTCCAACGAGCATCCAGAATGGGACGATGAGCGCATTTTCCAAACTGCAAGACTTATTTTGATTGGTGAAACCATCAAGATTGTCATAGAGGACTATGTACAGCACCTCAGTGGATACCACTTCAAACTCAAATTTGACCCAGAGCTGTTGTTCAACCAGAAATTCCAGTATCAAAATAGAATTTCTGCAGAATTCAACACCCTGTACCACTGGCACCCCCTTCTACCCGACACATTTGCCATCAGTGAAAAGGAATACAGTTACCCACAGTTTCTCTACAACAATTCTGTCATGTTAAACCATGGCCTCACCGAGATGGTTGAATCTTTCAGCAGGCAAACAGCTGGACGGGTTGCTGGAGGTAGGAATTTTCCTGCTGCTATAACCAGAGTAGCTGTGGCATCCATTGAGCACAGTAGAGAGATGAGATACCAGTCACTAAATGAGTACCGGAAGCGTTTCATGCTCAAACCCTTTGAGTCATTCGAAGAGCTAACCGGAGAGAAGGAAATGTCGGCTGAACTTGAGAAACTATACGGTGATATTGATGCCATGGAATTCTATCCTGGACTTCTTGTGGAACAGCCACGCCCTGGAGCTATCTTTGGAGAGACCATGGTAGAGATAGGAGCTCCATTCTCTCTAAAAGGCCTGATGGGCAACCCCATTTGCTCTCCTGAATATTGGAAACCTAGTACCTTTGGTGGAAGCGTGGGTTTTGATATTGTAAATTCCGCCTCTTTACAAAAGCTGATCTGCAACAATGTTAGAGACTGCCCTTACACTGCCTTTCATGTGCTAAAAAGCAAGCCTTCAGAGAAGGATTTCATTAATGCGAGTTCCGACTCAACACTGGAGAATGTAAAGCCATCTTTAATACTGAAAGAGCATGCGTCCGAACTTTAGTGTTTTTTCTTCTGAACCACTGTCACCCTTGTAGACACTATATGCAATGCTGGTTGTCTTTCACAACCACAAAGTGGAAAAAAAAGACCAGCAGCATGTAAAACTCCTGCGTATACATCTTTGTGTAGATTTTTTTTCTTCTTTTTTTTAAAATTGAAGGGGTTAATTTATTTATTTATTATTTATAATTTTATTTTTAACTGTCATGTCCAGTGCTGCCTCAGAATGTTTTTTGGTTGTCATTATATATTAATATATAATAATAATATTATTATATATTAATGAATAAATAAATGTATGTTTCACATACAGCTATTTGCACCAGAGTATCTTTAGATCATTTCTGTGTATACTTGAATTTATTAGATAAATGAAACTCACAAAATCGAGTCTTAAAACAATATTCAGTTGTCTTCCAAAATATATTGCCGGTATAGTGTGTTGTTTTTATATTAGTTCTTTCAAATATCTTGAAACCCTTACTTGAAATGTAATTGCACTGGACATCGGGCCAGTGATAGGCCAAACCTGTCAGCTTGGGACAGACTGGTAGAGCCATTTTATTCCTTGACATTAAAGGAACAGTAACACCACACCAAAATGTTTTTTTAAATAAATAAATAAATATAATTTACTGTTGCCCTGCATGGGTAAAAGTTAGCTTTATAAACACTAATATAGTCTAGTTTAGGCTACTATAGCCATGGGGGCAGCCATTTAAGATGGAGAAATGGAGTAAAGGCACAGGTTACATAAGGGATATGCTTTGTAGAATACAATGGTGCTTTACAGAGCTTATCAGTTATCTTCTATGTATCCTGTAAAGTGTAGCTCTATTTCAGTTTCAATACTTCAATACCCCTTGGCTACACAGCAGCTTGGTTTATATAAACTATAGTAGTGTTTCTGGAGCAAACACACAACTTTTACCAGTGCAGGGCAACAGTACATTATATCATATTATATATTACTTTCAAACATTTTCACTGTCATTTTTTGGTACTACTGTTCCTTTAAAGTTAGCTGTTTAATAAGATTGATTTACCATGCTGCTACTTTTCTTGATGATATTTAAGGAAATATAATATTGTATATATTAATATTATTTATAAAACTCTGTTTTTATAGAATTGTCACAATTGTAAAATTACCTTTTGTATGGTCGGAGCAGTCTAAAAAAAGTTTTATGTCTGTGGTCAACATTCCACTGTTACTGCCAGAGGTTGTGTTCCAGAATGTAATTTATGCTTGAGATAATGGATGTCATGTATTTATTTAAATTTAAATATTCTTTTATAAAGATATTTTTTTCTTTGTAATAAACAGATTTAGCACAGAGCAGGTTCTCTGGGTTATTGAAAAGAAGTGCTGGGTAATTAGGCTCATTTACAATCCACCATTTTTTTAGTTCGAATTTCAGTGTCATCTGCAGCGTTCACTGTTGTGTCAATATGTAGACATCAGAGCATGCCAAATGGGCTCACTAGCCCCTGCAGAAGACCCCTCTGAATGGCATCAGTGTATTCTCAGTTTTGCATCCATTTGTGCACTTAGCAATTTGTGCTCGTGTTTGTAAATGAGCCTTCTAGTGTGAGAATCTGACAGAATACATAATTCAACTTTCTTTTTCGTATTCGTTTTTCGTACAGTTATGTAGAATAGCAATAACACTAGCAAGTCGGGTCATTTTTTTTTTACGCAGACTAGAAGCCTATGCAATGCGACCCAGGGCATTATAGATTTCTATATGGTTTTTTTTTTTTTCAAATCTAATTTTGGTGAATAAAAGAAATGGCAAGTCTGTAATTTGTTAAAGTTTTATATTTTGTTGTGACTTCAGCTGTTATTGTATGATCATGTCACCATCAGGAATTTCTCGTTGTTTTTTACTGAACAAAAAAAAAAACATATTTTTACAAATAAAAATATTTGGCAAAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001093477|Xenopus laevis prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (ptgs2), mRNA GCGACACGATAAACACAGTGGGAGATACCAAGTCCGTAGCGCACAGGCCGCCTGCCCCTCTCACTCTCCAGTGGAATGATCGTACTACCCGCCGCTGTGTTCCTCGCTCTGCTGGTTTTCTCTCAAGCAGCAAACCCATGCTGTTCAAATCCCTGTCAAAACCAAGGGGTATGCATGACTGTTGGCTTTGACCGCTATGAATGCGACTGCACGAGAACTGGCTTCTATGGAGAAAACTGCACTAAACCGGAATTTTTATCATGGTTGAGGCTGAAGCTGAAGCCGACCCCCAACACCGTACACTATATCTTGTCTCACTTCAAGGGAGTATGGAATATAGTCAACAGCATGTCCTTCCTGCGGGACGCCATTATGAGATACGTCTTGACATCACGGTCGCACCTGATTGACAGCCCACCCACCTATAACAGCCACTATACATATAAAAACTGGGAGACATACTCCAACCTGTCCTATTATACTCGTTCCTTGCCTCCTGTGGAACGTGACTGCCCTACCCCAATGGGAGTTAAAGGACTGAAAGAACTTCCAAGTTCAAAGTTGGTAGTGGAGAAATTCCTGATGCGAAGAAAATTTATTCCTGACCCTCAAGGCACCAACGTTATGTTTGCTTTCTTTGCTCAACACTTCACACACCAGTTCTTCAAAACGGATATGGCAAAAGGGGCTGCCTTCACCAAAGCATTAGGCCATGGGGTTGATCTCAATCATGTCTATGGGGAAAGCTTAGAAAGGCAACATAAACTGCGTTTAATGAAGGGCGGAAAATTAAAATATCAGATGATAGATGGGGATATGTACCCACCAACAGTGAAAAGTTCAGGAGTAGATATGGCGTACCCACCCCATGTTCCAGAACATGTTCAGTTTGCTGTCGGGCAAGAAGTTTTTGGTCTTGTTCCTGGGCTTATGATGTATTCCACAATATGGTTACGGGAGCACAATCGAGTTTGTGACATACTTGCCGGGGAGCATCCAGAATGGGACGATGAACGTATTTTCCAAACGGCAAGACTTATTTTGATTGGTGAAACTATCAAGATTGTCATAGAGGACTATGTACAGCACCTCAGTGGCTATCACTTCAAACTCAAATTCGACCCACAACTGTTATTCAACCAGAGATTCCAGTATCAAAATAGAATTGCTGCAGAATTCAATACCCTGTACCATTGGCATCCCCTCCTACCCGACACATTTGCCATCAATGAAAAGGAGTACAGTTACCCACAGTTTCTCTACAACAATTCGGTGATGATAGACCATGGCCTTACCCAGATGGTTGAATCTTTCAGCAGACAGTCGGCAGGAAGGGTTGCTGGGGGTAGAAATTTCCCTGCAGCTATAACTAGAGTAGCTGTGGCATCCATTGAGCACAGTAGAGAGATGAGATACCAGTCACTGAATGAATACCGGAAGCGTTTCATGCTCAAACCCTTTGAGACGTTCGAAGAGCTGACAGGAGAGAAAGAAATGTCAGCTGAACTTGAGAAACTATACGGTGATATTGATGCCATGGAGCTCTATCCTGGACTTCTTGTGGAACAGCCGCGCCCTGGAGCTATTTTTGGAGAGACAATGGTAGAGATGGGAGCTCCATTCTCTCTAAAAGGCCTAATGGGAAATCCCATATGCTCTCCTGAATACTGGAAACCTAGTACCTTTGGCGGAAGCGTGGGGTTTGATATTGTAAATTCCGCCTCTTTCCAAAAGCTGATTTGCAACAACGTGAGAGACTGTCCTTACACCGCCTTTCATGTGCTAAAAAACAAGCCTTCCGGAAAGGATTTCATTAATGCGAGTTCAGATTCAACACTGGAGAATGTAAAGCCATCTTTAATCCTGAAAGAGCACACATCCGAACTTTAAACTGACACTTCAGTATCGACAAAGTATTTATTTGTCTGAAACCACTGTCACATTTGTATATAGTATACACAATGCTGGTTGGGATTGATAGGATTACTGGGTGGGCATAAAGACCAGCAGGGTTCAAACTCTTTCAAAACAACCTTTATTTTCTTTCTTTTGTTTTACATTACGGGGGGTTAATTTATTTATTTATTTTTTATAATTTAAATGTCCTGTGCTGCCTCAACATGTCTTTTGGTTGTCAATATATATTAATATATAATATGATTATATATTAATAAATATGTATATATCCTCACTGTATTTCACAAACAACTTCCTAGTAGCTTCAAATCATGTCATCTGTATACAAATCCTGCATATATTTGAATATGTGCATTTGATAGATATACAAAACAATTAAGCCTTAAATCAATCATCACTTGTCTTCCAAAATGTGTTTTGGAGGTGCAGTGAGCTCGTCTTTCAAACCAATATATACATATACTGTACATTAGTTCTTTAAAAAATCCAGTAAAACCACAGGTTCATTGTTGAAACTCTTACTTGAAATATAACTAACTGCACTGGACACTGGGACAGTGAAGTCTGATAGAGCCATCTTATTGTTTAAAGTTAATTGTTTCTTAACATTGATTTACCATGCTGCTAATTGTTCATGATATTTAAGGAAATATATTGTATATATAAATAATATATTATTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001025697|prostaglandin G/H synthase 2 precursor [Xenopus (Silurana) tropicalis] MIVLPAAVFLSLLVFSQAANPCCSNPCQNRGVCMTVGHDRYECDCTRTGFYGENCTKPEFLSWLRLKLKPAPNTVHYILTHFKGLWNIVNNISFLRDAIMRYVLTSRSHLIDSPPTYNSHYGYKSWEAFSNLSYYTRTLPPVERDCPTPMGVKGMKELPSAKLVVEKFLMRRKFIPDPQGSNVMFAFFAQHFTHQFFRTDMAKGAAFTKALGHGVDLNHIYGESLERQHKLRLMKGGKLKYQMISGEMYPPTVKTTGVDMVYPPHIPDHLQFAVGQEVFGLVPGLMMYSTIWLREHNRVCDILSNEHPEWDDERIFQTARLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQKFQYQNRISAEFNTLYHWHPLLPDTFAISEKEYSYPQFLYNNSVMLNHGLTEMVESFSRQTAGRVAGGRNFPAAITRVAVASIEHSREMRYQSLNEYRKRFMLKPFESFEELTGEKEMSAELEKLYGDIDAMEFYPGLLVEQPRPGAIFGETMVEIGAPFSLKGLMGNPICSPEYWKPSTFGGSVGFDIVNSASLQKLICNNVRDCPYTAFHVLKSKPSEKDFINASSDSTLENVKPSLILKEHASEL	Refseq >NP_001086946|prostaglandin G/H synthase 2 precursor [Xenopus laevis] MIVLPAAVFLALLVFSQAANPCCSNPCQNQGVCMTVGFDRYECDCTRTGFYGENCTKPEFLSWLRLKLKPTPNTVHYILSHFKGVWNIVNSMSFLRDAIMRYVLTSRSHLIDSPPTYNSHYTYKNWETYSNLSYYTRSLPPVERDCPTPMGVKGLKELPSSKLVVEKFLMRRKFIPDPQGTNVMFAFFAQHFTHQFFKTDMAKGAAFTKALGHGVDLNHVYGESLERQHKLRLMKGGKLKYQMIDGDMYPPTVKSSGVDMAYPPHVPEHVQFAVGQEVFGLVPGLMMYSTIWLREHNRVCDILAGEHPEWDDERIFQTARLILIGETIKIVIEDYVQHLSGYHFKLKFDPQLLFNQRFQYQNRIAAEFNTLYHWHPLLPDTFAINEKEYSYPQFLYNNSVMIDHGLTQMVESFSRQSAGRVAGGRNFPAAITRVAVASIEHSREMRYQSLNEYRKRFMLKPFETFEELTGEKEMSAELEKLYGDIDAMELYPGLLVEQPRPGAIFGETMVEMGAPFSLKGLMGNPICSPEYWKPSTFGGSVGFDIVNSASFQKLICNNVRDCPYTAFHVLKNKPSGKDFINASSDSTLENVKPSLILKEHTSEL

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.15770	Xl.78035
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	PTGS2
mouse		MGI	Ptgs2	All(15) Targeted, knock Out(4) Targeted, other(9)
zebrafish		ZFIN ZFIN	ptgs2a ptgs2b	1 Lines(s)

Publications
First:		Pharmacological evaluation of 1-(carboxymethyl)-3,5-diphenyl-2-methylbenzene, a novel arylacetic acid with potential anti-inflammatory properties. [Inflamm Res 1998]
Most recent:		The developing Xenopus limb as a model for studies on the balance between inflammation and regeneration. [Anat Rec (Hoboken) 2012]
		View All Papers

Functional Ontologies
GO: Molecular:		peroxidase activity prostaglandin-endoperoxide synthase activity
Biological:
Cellular Component:
EC:		prostaglandin-endoperoxide synthase
KOG:		[R] Peroxidase/oxygenase

Reagents		tropicalis	laevis
Clones			EXRC - 1 clone(s)
		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.15770.1.S1_at	Xl.7740.1.A1_at
Affymetrix 2.0			Xl2.33329.1.S1_at [+] Xl2.33329.1.S2_at

Symbol legend[+]

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