Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (14) GO Terms (13) Nucleotides (59) Proteins (12) Interactants (129) Wiki
XB-GENEPAGE- 484031

Gene Symbol: igf1r

Gene Name: insulin like growth factor 1 receptor

Synonyms: xIGF-1R , xIGFR , xigf1r , igf-1r , XTK2
Add Xenopus synonyms , Nomenclature history


Gene Function: growth factor receptor, contains protein kinase domain

Protein Function:
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. Plays a role in oocyte maturation. Promotes head development by inhibiting Wnt signaling during embryogenesis.

Interactants: igf1 (8) , ins (8) , insr (5) , pax6 (5) , igf2 (4) , otx2 (4) , actl6a (3) View All

OMIM Disease Associations: INSULIN-LIKE GROWTH FACTOR I, RESISTANCE TO
 
Xenbase Gene ID XB-GENE-484032 XB-GENE-17333511 XB-GENE-865040
Genome X. tropicalis X. laevis L X. laevis S
Gene Symbol igf1r igf1r.L igf1r.S
Chromosome Chr03 chr3L chr3S
Molecules tropicalis laevis .L laevis.S
Gene GBrowse 8.0 GBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 GBrowse 9.1 GBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide Refseq
Protein Refseq Swiss-Prot
Genomic tropicalis laevis .L laevis.S
Genome Browser
GBrowse
tropicalis genome v8.0 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis .L laevis.S
Ensembl Ensembl
UniGene [+] Xl.269
RNA-seq profile: Owens, Blitz et al. 2016 igf1r
Images 2 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis .L laevis.S
XenMine igf1r igf1r.L igf1r.S
Phenotype tropicalis laevis .L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards IGF1R OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Igf1r MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN
chicken
GEISHA IGF1R Ensembl
fruit fly
worm
WORMBASE
Publications
First: Genes encoding receptors for insulin and insulin-like growth factor I are expressed in Xenopus oocytes and embryos. [Proc Natl Acad Sci U S A 1991]
Most recent: MicroRNAs are critical regulators of tuberous sclerosis complex and mTORC1 activity in the size control of the Xenopus kidney. [Proc Natl Acad Sci U S A 2014]
View All Papers 5 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis .L laevis.S
GO 0 term 0 term 13 terms
EC now EC:2.7.10.1 and EC:2.7.10.2
PANTHER igf1r
KEGG K05087
KOG [T] Insulin/growth factor receptor (contains protein kinase domain)
Reagents tropicalis laevis .L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
geneservice/RZPD imagenes
Antibody Insr Ab1 Insr Ab1
Morpholino igf1r MO1 igf1r MO1 igf1r MO1
Affymetrix 1.0 Str.32073.1.S1_s_at [+] Xl.269.1.S2_x_at [+]
Affymetrix 2.0 Xl2.269.1.S1_at

Symbol legend[+]

My Xenbase: [ Log-in / Register ]
version: [4.2.0]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556