Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (11) GO Terms (37) Nucleotides (94) Proteins (39) Interactants (208) Wiki
XB-GENEPAGE-484375
Gene Symbol:
irx5

Gene Name:
iroquois homeobox 5

Synonyms:
iroquois-5 , Xiro5 ( Add synonyms , Nomenclature history )

Gene Function:
homeodomain transcription factor

Protein Function :
Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Patterns the neuroec...[+]


InterPro :
Cadherin cytoplasmic-dom , Cadherin CS , Catenin binding dom sf , Cadherin-like dom [+]

Interactants:
Loading ...

Diseases: 


OMIM:
HAMAMY SYNDROME; HMMS

External Links:
 
Xenbase Gene ID XB-GENE-484376 XB-GENE-865076 XB-GENE-17336278
Gene Symbol irx5 irx5.L irx5.S
Chromosome Chr4 Scaffold116 chr4S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100038201
373841
108715340
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein RefSeq RefSeq Swiss-Prot  More.. NCBI Protein TrEMBL
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine irx5 irx5.L irx5.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards IRX5 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Irx5 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Irx5 Ensembl
zebrafish
chicken
GEISHA IRX5 Ensembl
fruit fly
worm
Publications
First Expression of two novel mouse Iroquois homeobox genes during neurogenesis., Mech Dev 2000  
Most Recent Id genes are essential for early heart formation., Genes Dev 2017                  
All View All Papers 3 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 36 terms 12 terms 7 terms
PANTHER irx5
KEGG Pathways
KOG [K] Transcription factor MEIS1 and related HOX domain proteins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks irx5
Morpholinos (on-target & off-target) irx5 MO1 irx5 MO1 irx5 MO1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info