Gene Symbol: ptk2b Gene Name: protein tyrosine kinase 2 beta Synonyms: pkb, ptk, cakb, fak2, pyk2, cadtk, fadk2, raftk Add Xenopus synonyms Gene Function: serine/threonine kinase Interactants: akt1(29) , sgk1(17) , ins(12) , sgk3(8) , mapk1(6) , nedd4(6) , nedd4l(6) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene
mRNA		Refseq >NM_001011049|Xenopus (Silurana) tropicalis PTK2B protein tyrosine kinase 2 beta (ptk2b), mRNA CCGGGCTCATACCTGCCAGTGCCACATTCCTGAGCCACAGTAGCACCCAGCAGGCACCCAAGGGGCCACCAGATACGTAATGTGCTGCTCATAGTCTCCTCATTGGGGGTCCCAGGATGTCGCTGGACCATGCCAACCGGACCAAGGGGGGCACATTTAACCGGCCAGATGGCCCGGCGGAGGTGCCGGCGGAAGTGGAGATCAGTAAGGAGGAGATGAGAATCCTGAAAGTGTGCTTCCACAGTAACAGCTCCAACCTGGTAAAAAATTTCAAGCTGGTGAAATGCAGCATCTACACGGATATACAGGAGATTATCAGCTCAATACTGCTGAGCGGTCGGATAGGGCCGGACATCAAACACGTTGAGTGTTACGGTCTGCGTCTGAAGCATCTGAAATCCGTTACCTGCCCGAAGACTTCAATGAAAGTTTTAAAAAGGACAAAACTACCTTGTTATATTTCTATCAGCAGCTCAGAAATGACTACATGCAACAATACGCAACGAAAGTGAGCGAAGGCATGGCCTTGCAGCTGGGATGCCTGGAACTCAGGAGGTTTTATAAAGATATGCCCCAGAACGCTCTCGAGAAGAAATCCAACTTCGAATTTTTAGAGAAGGAAGTGGGACTGGATTTGTTCTTCCCAAAACAGATGCAGGAGAGTTTGAAGCCTAAACAATTCCGCAAGATGATCCAGCAGACATTCCAGCAATACGGATCCCTCAAGGAAGAGGAATGCATTACGCGCTTTATGAACACCCTTTCCACTTTCACCTCCATCGATCAAGAAACCTACAGATGTGAATTAGCGCAAGGATGGAGCATCACTGTTGACTTGGTTATAGGCCCCAAAGGCATTCGGCAGCTGACTACCAAGGACTCTAAGCCGACATGCTTTGCCGAATTCAAGCAGATAAAGTCCATCAAGTGCTCGTTGCTAGAAGATGGCTGGGCCTTGCTGTTACTGGGTATATCGGGCGCCCCACAGCCTTTAGCCATAAAAACATCGTCGTTGGCAGTGGCGGAAAACATGGCCGACCTCATCGACGGTTACTGCCGGCTGCAAAACGAGTCGAAAGATTCGCTCATTGTCAACCCCAAGAAAGATAATGAGAAGAGGATCAGCCTGCCCCAGATCCCAACTGAAGAAGTACAAGTGCGGCGATCCAGGCTAGTGGAGGGGAACAGTATGGAGTCAGACATATACGCAGAGATTCCGGAGGTGACTGAGACAAAGCTTACAAATAACCGTTTCACCATCAGCCGAAGCGACGTGGCGCTGGGGAGGATCCTGGGAGAAGGCTTTTTTGGGGAGGTCTACGATGGCGTCTATGTGAAACCGAAGGGCGACAAGATCAACGTGGCGGTAAAGACCTGTAAGAATGACTGCGCCGCCGACGTCAAGGAGAAATTCATGAGTGAAGCGTATCTGATGAGGAACTTGGACCACCCGCATATAGTAAAACTAATTGGCATCATTGAAGACGACCCAATATGGATTGTGATGGAGCTGTACCCGTACGGAGAGCTTGGGCAGTACCTAGAGAAAAACAAGAACTCCCTGCAGGTTCTCAGCCTCATCCTCTACTCACTACAGATCTGCAAAGCCCTCGCCTACTTAGAGGGAATAAACTGCGTCCACAGGGACATTGCTGTACGGAACATTCTGGTAGCTTCTCCTGAGTGTGTGAAACTGGGAGACTTTGGCCTTTCTCGGTACCTAGAGGAGGAAGAGTATTATAAAGCTTCAGTCACCCGGCTGCCAATCAAGTGGATGGCTCCGGAGTCCATTAATTTCCGGCGGTTCACCTCGGCCAGCGATGTCTGGATGTTTGGAGTCTGTATGTGGGAGATACTCTCCTTTGGGAAGCAGCCATTTTTCTGGCTGGAGAACAAAGACGTGATCAGCGTAATCGAGAAGGGAGATCGCCTGCCCAAACCCGAGATGTGCCCGCCGACCCTCTACACCCTGATGACGCGCTGCTGGACTTATGACCCTTTCGAGAGGCCGAAATTCACCGAGCTTGTTTGTAGCCTCAGTGATATTTATCAGACAGAAAAAGAGATCATCAAAGATAAAGAGAGGAACAACCGCCAGCGGCCTCCTAAAATCATTGAGCCTCCTCCCATGCAAGAACCTCCCCCAAAGCCTAGCCGGCCCAAATACAAGGCAGCCGCGCCCGGAAATCTGCTGGCACCTAACCTACTGACCCAGGTACCAGAGAGTCTATGTGCCAGCTCTCCTACTCTCTGTAGCCCAACTGACTACCAGTCTCCACTGGATTCCACCCGCAGCCCACCACTGCCGCGCCATAGCATCTTCAAACGCCGCAGCATGAGGGAGGAAGACTTTGTAAAACCGAACAGCAAAGAAGAAGCTCAGAAACTGTGGGAAAAGGAAAGGGACAAAATGCTACAGGTCTTAAACCGACAGCAACAACAGATGGAGGAGGACGGCAAGTGGTTGAAGCAGGAGGAGAAGTCACTGGCCAATACTCTCAAGGATTCAAAGCAAAAAACAAACAACAACAAGCCCCCTGATGCACTTCCAGAGAAAGAACTGGCGTACACTGAATTCACAGTCCCCCCACAGAAGCCTCCCAGGTTAGGGGCACAGTCCCTACAACCCCTACAGCCCACACCTACGGCCAACATTGACCGGACAGATGACGGTGTGTACCAAAGTGTGATGGAGCTGGTAAAGGCGGTTCTGCAACTGAAGAATGACATCTACCAGCTCCCTCCGGAGGGATACGTTGCCGTTGTTAAGAATGTGGGGCTGACCCTTAGAAAACTCATTGGAAGCGTCGATGAGATCCTTCCTTCTCTCCCACAGAATTCCCGCACCGAGATTGAAGGGACCCAGAAGCTCCTAAGCAAAGACCTGGCGGAGTTAATCAACAAGATGCGCCTGGCCCAACAGAACGCCGTGACGTCGCTGAGCGAAGAGTGCAAGAAGCAGATGCTGACGGCGTCGCACACCATGGCCGTAGACGCCAAAAATTTGCTGGATGCCGTGGACCAGGCCAGGGTCAGGGCCAATTTAGCCAAGGTGGCCGCTGAGTGACACGGATTCACCTCTCCAAAAAGAGACATCGGTGTTCCTATTGGTGTCCCCGTGAATCCTTCCCAACGGCTTGTAAAATACTCTGCTGCTATCAGAACCTGACTGAATGGGTCCCCGCATAGAACCCAGAGGAAAGTCCGTATTTGGAGACTTGTGCTGAAGCAGTGGCCCCCGGGGCCCCTCACCTCGCTGCCATAAAGCAACAGGCAACTTTGTTACATGAAAAGGAACTGGAACCTCAACGACTTTCATCGGAACATTTTGGGAACATTTCTGATTAACGTGTGGAAATGGTTTACACTGAGGGTGGAACAACCCAACGGGCTCGCGCCAACCTCCGTTTACTTACCGGGAACAGAAATGACAAGAACTGGAGATGGAAATACTGTCTAAAAGCAGAATGATCTTCCTCACAAATATTATTATCTCATTGCTTTTTTCCGTTCGTCCCTTGTGAGATGTTGTGGCAAAACCAATTCTGGTTTCCGCTGCCCTCGGAATGGGGCAAAGGGGCCGCGTATAAAGGGTGTGTGCCGTAACCCGAGGTGTCATTTTGGCTACATCCGTTCCCAAAGCCGGCCATACGCATTCAGATTAAAGTCTTCTTCCCGCGAATGTATTGTAAATTGTAGGATAAAGCCGTAAATATAACCAATGGGATGAGGTTCTGAGCATGAAATAGTTACAGGCACCAATCGTACGAAAGTGACTCCCACTGTAGGGCCCCAAGGGTATCAGCAGATACACAATACTGCACAGATTTTATCCTTATCCAACCGGAATTTTCTAACCCGTCCAACCGACTAAACGACCGATGGTACGAAAATTATCGGGATGATAATTTGGAAACCCCCACAGGGTCCGATAATCGTGCACAACTGTGTTTCTTATGATAAAAGATTTTGATCGGGCGCCCCAGTGTCAGACTGGGGGGTGAAGGGCCCACCGGGGCATCTAATCGCCCCCCCTCAGGGGCCCCTCACCCTACGTCCTCCCCCGAGCGCGGAAATTTAACGCTTCAGGGGAGGAGCTGTCGGGCAGGGGGAGCATCGGCAAAGGGTCAGGTCTGGGCTGCCAGGGCCCATTGGGATTTTTCCCGGTGTCCCGGCGGCCCAGTTCGACCCTGGGGCGCCCGAGCAAAATCTACGTTCAGGGCTGAATTGGCAGAAGAAGGTAGAAATCCTATTGTTTCTATATTCAACCCTGAACGTCTGTGGAGGAAGGAAAAGATGGGAAATCCCTACAAGTATGGCCACCTTTAGTGCGGATATCTCTGGCTATAACTCCAAGTAACTGCAGAAATAACTGAAATTTAGAGATATAGTCAAAGGTATCCCAAAATGATATTAATGGCTATAGCCTAGGTATAGCCCAACCCCACTATATCTGTAAGCAGCTACGGAAATAACAGCCTATGGAATCCTGAGGGATCACATGGGGGGTAACTCTGGATACACCTGTATTTAGCCAAAATGGCTACACCAGATGTAGCCAAAATGAATCCCAAAGTGCAATGCCAGGCTGTCTCTGATAGCTACAGATATGGCCAGAATTGTCCCAATGTGATATCTAAAGGTGCCCATACATGGGAAGGGTGCGAAGTAGATCTTCTCCCGATATGCCCGCCTAAAGGAGGGCAAAATCGGACTAATTCTATTGTTTGGCCCTAGGGTTGAATTACAACGGCGGCTATAGGCGCTGCCGGACTGAGTGCCACATCAACGAGACAATGCTGTGCCCAATCCAATGGAAAATCAATCCTGCCCGATCATGATCTGCCCAATTTTAGCCCAGATATCGGTTGGGTTGGCCTGTCAGGGGTGCCCATACACGTGCAGATAAGTTTCCGAATCGGTCTGAAGGATTCATACTAGCATCTGTATGGCCACCTTCCCAGATGTAGCCAAAATAAATCTCAAAGTGCAATCCCAGGCTTCCCCTGATAGCCACAGATATGGCCAGAATTGTCCCGATGTGATATCTAAAGGTGACCATACATGGGAAGGGCGCCAAACAACCGGATCTTCTCCAGATAGGTCCACCTAAAGGAGGGCAATATTGGACTAATTTGATTGTTTGGCCCTAGGGTTGAATTACAGCGGTGGCCATAGGCGCTGCCGGACTGAGGGCCGCATCAACAAGACAATGCTGTCCTTAATCCAATGGAAAATGAAACCTGCCCGATCAAGATCTGTCCAATTTTAGCCCAGATATCGGTTGGGTAGGCCCATCAGAGTTGCCCATACACAGTCAGATAAGCTGCTGAATTGGTCTGAAGGATTTAAACTTGCATCTGTATGGCTGCCTTCCCGGATGTAGCCAAAATGAATTCCCGGGCTACCCCTGATAGCTACAGATATAGGCAGGGATAGCCCAGGGACAGCTGGAGATACCACATTTAGATAACCCTGGCTACACCTGTAGGAGAAATAACTGTCTGTAGTACCCAGGGGTCTCATTTTGGGATAATTAGTGCTCCCTCTGTAACGAATAGGGGCAACTGGCTGCTGTAACCATGGTATCTTTGTCTATAGAGGGGTCTTAAGAGGTTTATAGGGTCACATTCACAGTGAGAGATGTACAGTTTGCCTGGGGCAATAAATGGAACAAAATAAGTGTCTGTTGCACAACATGTAGAAATATAACATGGGGGGGGGGGTACCAATGTATTGCGTGAGCTTAATGGACATTTTAACCCCAAAAAATTAGTTTTTGCCTAATAAAACGAAACATAATTTTTTATTAGGCAAAAAATTATATTATGGGTTGACTTGTCCTTTAAAGTTTACTGCCTACACGTGGGCATCTGAATGCCCTTTCCATATGCCAGGGATACCCATTAGTCTCCAATGACACTTCCCAGAATCCATTGCCCTAGTTTCACTGGAACTGGGAGAACAGCTGGGGGTCTCTGCTCTGCATCAACTCCCAGCACCCCAGCACCAACTCCCAGCACCCCAGCACCAACTCCCAGCACCCCAGCCCCAACTCCCAGCACCCCAGCCCCAACTCCCAGCACCCCAGCACCAACTCCCAGCACCCCAGCACCAACTCCCAGCACCCCAGCCCCAACTCCCAGCACCCCAGCCCCAACTCCCAGCACCCCAGCCCCAACTCCCAGCACCCCAGCACCAACTCCCAGCACCCCAGCCCCAACTCCCAGCCCCAACTCCCAGCACCAACTCCCAGCACCAACTCCCAGCCCCAACTCCCAGCACCAACTCCCAGCACCCCAGCACCAACTCCCAGCACCCCTTCAACATTCCGATCCCCCCCAAAATGCCCCTGACAAACAGGAAGTGCGTGTTGGCGCGTCCCAGGTTTCCCTTTTGTACATAGTTTGCCTTTTCCTTTGAAATTCTTTCCAGGTTTAAATATAAATGGATTTTAATATGACGTCTATTTTCTTTCCTCCTGTGGGGCTGGAAGCAGCAGAACTATAACTCTGGGATCTGAGAAACGTTATGTGGGTCTGTATTTTGCCGTCTTCATTCCAAAAAAAAAAGATTTTATTTAAATGTATTATATATACAGTATATAAAATTGAGCAGGAATGTGATGGCGCCACTGAGGCTGAACTGTATTTATTACTATACCCGCTCTGGGGCAAGTGTGGGGCACAGCATATAGTGGGGATAGAGGGAGAGAGGTGGAATAAAACATATAAAAACAAATACAGTCTGTCTGAGGGGTAGAAATATATGTATAAATCTAGTGGCATTGCCAGGCATACAGGGAATACGTATAATTACATGGAACCTGGAACCCAGCCATACTGGGCGCACTGGTCTCTTCATGCTATTGTTTTATTGTATTGACTTTTATATCTAATGGATGTTTTATGGGTGTTTTTCTACGTCTGTAAGCTGCCATCTTGCCGTAAGTCCGGCCCACTCCTCCCAAGTCACTGACTCCGCCTGTGTACGTGCAGAATGAGTAGCCATTGGTGTATCCTGTACAGAGGGCGGTACTTGGAGACTCATAGAGGGGTGTTGCCCAGAAAGTATCTGGACATTCACCTGCCCAATATTACCCAAACCAAGGGGTTAATATGAAGTTGCTCCTCCCTTTGCTGCTATAACTGCCCCTGCCCCTCTGGGAAGGTTCCCACTAGATGTTGGAGTTGCTGGGAGTTGCTCCCATTCAGCCACAAGGGCATTAGTGAGGTTGGGCAGTGATGTTGGGGATCAGGCTCACAGTCGGGGTTCCATCCCACAGGGGTTCAGTTGGGTTGGGTCAGAGCTCTGTGCAGGTTCTTCCCATCTCAGCAAACCCATTCTGTAGGGCCCATCTCTGTACATGGGGGACATTATTGTGCTGAAACAGGAAAGGGCCCCCCCAAACTATTCCACAAAGTAGGGAGCACAGAATTGCCGGGAATGTCACTGTACCCTGTAGCCTTAAGGTTTCACTGGAACCAGGGGCCCAAAGCATTGAAACAGCCCATTGTGTGCCCAGAACATTCCTTCTCTGTATATTTGTATTTATACATATGGGTAGGAGGTGCCATAGTGTTTCCCTTAGACAGTACAGGGTGAGGGGAATGCTGTGGGCCCGTTACTCCCCTTGCCGTTGGTACTGGTCCCGGGGCCACTGTATGAAGCCGCTTGTCTCTGTGTGACTGCTCATTCCCTGCCCACGTGCTGCCGCTGCTGCTGTATGTAATGCTGTACGGTTCCCCCCTGTGTGTAATATACAAGCCCGGCCCATTGCTGGAGCCATTTGTAAATAATCCTCTATTAAAGGCCACATTACTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001011049|PTK2B protein tyrosine kinase 2 beta [Xenopus (Silurana) tropicalis] MQQYATKVSEGMALQLGCLELRRFYKDMPQNALEKKSNFEFLEKEVGLDLFFPKQMQESLKPKQFRKMIQQTFQQYGSLKEEECITRFMNTLSTFTSIDQETYRCELAQGWSITVDLVIGPKGIRQLTTKDSKPTCFAEFKQIKSIKCSLLEDGWALLLLGISGAPQPLAIKTSSLAVAENMADLIDGYCRLQNESKDSLIVNPKKDNEKRISLPQIPTEEVQVRRSRLVEGNSMESDIYAEIPEVTETKLTNNRFTISRSDVALGRILGEGFFGEVYDGVYVKPKGDKINVAVKTCKNDCAADVKEKFMSEAYLMRNLDHPHIVKLIGIIEDDPIWIVMELYPYGELGQYLEKNKNSLQVLSLILYSLQICKALAYLEGINCVHRDIAVRNILVASPECVKLGDFGLSRYLEEEEYYKASVTRLPIKWMAPESINFRRFTSASDVWMFGVCMWEILSFGKQPFFWLENKDVISVIEKGDRLPKPEMCPPTLYTLMTRCWTYDPFERPKFTELVCSLSDIYQTEKEIIKDKERNNRQRPPKIIEPPPMQEPPPKPSRPKYKAAAPGNLLAPNLLTQVPESLCASSPTLCSPTDYQSPLDSTRSPPLPRHSIFKRRSMREEDFVKPNSKEEAQKLWEKERDKMLQVLNRQQQQMEEDGKWLKQEEKSLANTLKDSKQKTNNNKPPDALPEKELAYTEFTVPPQKPPRLGAQSLQPLQPTPTANIDRTDDGVYQSVMELVKAVLQLKNDIYQLPPEGYVAVVKNVGLTLRKLIGSVDEILPSLPQNSRTEIEGTQKLLSKDLAELINKMRLAQQNAVTSLSEECKKQMLTASHTMAVDAKNLLDAVDQARVRANLAKVAAE

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.27426
Unigene EST Profile		EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	PTK2B
mouse		MGI	Ptk2b	All(3) Targeted, knock Out(3)
zebrafish		ZFIN	ptk2bb

Publications
First:		p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo. [Oncogene 1992]
Most recent:		PKB/SGK-resistant GSK3 enhances phosphaturia and calciuria. [J Am Soc Nephrol 2011]
		View All Papers

Functional Ontologies
GO: Molecular:		ATP binding protein kinase activity protein serine/threonine kinase activity More[+] protein tyrosine kinase activity
Biological:		protein amino acid phosphorylation
Cellular Component:		cytoskeleton
EC:		now EC:2.7.10.1 and EC:2.7.10.2
KOG:		[T] Focal adhesion tyrosine kinase FAK, contains FERM domain

Reagents		tropicalis	laevis
Clones		open biosystems
		geneservice/RZPD imagenes
Affymetrix 1.0		Str.27426.1.S1_at [+] Str.34523.3.A1_at
Affymetrix 2.0

Symbol legend[+]

- Blast this sequence
   - Literature Or Expression Images