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Summary Expression Gene Literature (11) GO Terms (17) Nucleotides (319) Proteins (46) Interactants (292) Wiki
XB-GENEPAGE-489534
Gene Symbol:
gsn

Gene Name:
gelsolin

Synonyms:
gelsolin ( Add synonyms , Nomenclature history )

Gene Function:
actin binding

Protein Function :
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of...[+]


InterPro :
Villin/Gelsolin , Gelsolin , ADF-H/Gelsolin-like dom sf , Gelsolin-like dom [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
Finnish type amyloidosis

OMIM:
AMYLOIDOSIS, FINNISH TYPE

External Links:
1/3
 
Xenbase Gene ID XB-GENE-489535 XB-GENE-17331566 XB-GENE-865877
Gene Symbol gsn gsn.L gsn.S
Chromosome Chr8 chr8L chr8S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 549610
108698207
397895
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. NCBI Protein NCBI Protein  More.. NCBI Protein RefSeq  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine gsn gsn.L gsn.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards GSN OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Gsn MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Gsn Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR gsna gsnb ZFIN Ensembl
chicken
GEISHA GSN Ensembl
fruit fly
worm
Publications
First Proteins regulating actin assembly in oogenesis and early embryogenesis of Xenopus laevis: gelsolin is the major cytoplasmic actin-binding protein., J Cell Biol 1988                    
Most Recent Regulation of actin assembly by PI(4,5)P2 and other inositol phospholipids: An update on possible mechanisms., Biochem Biophys Res Commun 2018  
All View All Papers
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 14 terms 7 terms 10 terms
PANTHER gsn
KEGG Pathways K05768 K05768
KOG [Z] Actin regulatory proteins (gelsolin/villin family)
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks gsn
Antibodies Gsn Ab1 Gsn Ab1
ORFs gsn.S ORF1
Clones Horizon Source BioScience Horizon Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info