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Summary Expression Gene Literature (14) GO Terms (19) Nucleotides (150) Proteins (40) Interactants (182) Wiki
XB-GENEPAGE-493607
Gene Symbol:
plk4

Gene Name:
polo like kinase 4

Synonyms:
plx4 ( Add synonyms , Nomenclature history )

Gene Function:
serine/threonine kinase

Protein Function :
Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment ...[+]



Interactants:
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Diseases: 


OMIM:
MICROCEPHALY AND CHORIORETINOPATHY, AUTOSOMAL RECESSIVE, 2; MCCRP2

External Links:
 
Xenbase Gene ID XB-GENE-493608 XB-GENE-866273 XB-GENE-17339513
Gene Symbol plk4 plk4.L plk4.S
Chromosome Chr01 chr1L chr1S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100038180
398770
108706689
mRNA RefSeq RefSeq NCBI Nucleotide
Protein RefSeq Swiss-Prot RefSeq NCBI Protein
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine plk4 plk4.L plk4.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards PLK4 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Plk4 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Plk4 Ensembl
zebrafish
ZFIN, AGR plk4 ZFIN Ensembl
chicken
GEISHA PLK4 Ensembl
fruit fly
worm
Publications
First Cep152 interacts with Plk4 and is required for centriole duplication., J Cell Biol 2010            
Most Recent Centriole Number and the Accumulation of Microtubules Modulate the Timing of Apical Insertion during Radial Intercalation., Curr Biol 2020            
All View All Papers 1 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 19 terms 9 terms 4 terms
PANTHER plk4
KEGG Pathways K08863 K08863
KOG [D] Polo-like serine/threonine protein kinase
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks plk4
Morpholinos plk4 MO1 , plk4 MO2 plk4 MO1 , plk4 MO2 plk4 MO1 , plk4 MO2
ORFs plk4.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
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