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Summary Expression Gene Literature (11) GO Terms (17) Nucleotides (248) Proteins (60) Interactants (154) Wiki
XB-GENEPAGE-5760737
Gene Symbol:
dyrk1a.2

Gene Name:
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, gene 2

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
Dual-specificity tyrosine-phosphorylation regulated kinase

Protein Function :


InterPro :
Kinase-like dom sf , DYRK1A/B MNB , Protein kinase ATP BS , Ser/Thr kinase AS [+]

Interactants:
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Diseases: 


Disease Ontology:
autosomal dominant non-syndromic intellectual disability 7

OMIM:
MENTAL RETARDATION, AUTOSOMAL DOMINANT 7; MRD7

External Links:
1/2
 
Xenbase Gene ID XB-GENE-5760738 XB-GENE-5760801 XB-GENE-17346025
Gene Symbol dyrk1a.2 dyrk1a.2.L dyrk1a.2.S
Chromosome Chr7 chr7L chr7S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100145447
108696938
379954
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. NCBI Protein NCBI Protein  More.. NCBI Protein RefSeq  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine dyrk1a.2 dyrk1a.2.L dyrk1a.2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards DYRK1A OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Dyrk1a MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Dyrk1a Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR dyrk1aa dyrk1ab ZFIN Ensembl
chicken
GEISHA DYRK1A Ensembl
fruit fly
worm
Publications
First Two dual specificity kinases are preferentially induced by wild-type rather than by oncogenic RAS-P21 in Xenopus oocytes., Front Biosci 2006  
Most Recent Correction: The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos., Development 2020  
All View All Papers 1 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 17 terms 5 terms 0 term
PANTHER dyrk1a.2
KEGG Pathways K08825 K08825
KOG [R] Dual-specificity tyrosine-phosphorylation regulated kinase
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks dyrk1a.2
ORFs dyrk1a.2.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

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