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Summary Expression Gene Literature (17) GO Terms (22) Nucleotides (79) Proteins (23) Interactants (110) Wiki
XB-GENEPAGE-5828963
Gene Symbol: dna2

Gene Name: DNA replication helicase/nuclease 2

Synonyms: xdna2 ( Add synonyms , Nomenclature history )

Gene Function: DNA replication helicase

Protein Function :
Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape fen1: flaps that are longer than 27 nucle...[+]

Interactants: Loading ...
Disease Ontology: Seckel syndrome 8

OMIM Diseases: PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS, AUTOSOMAL [+]

 
Xenbase Gene ID XB-GENE-5828964 XB-GENE-17338476 XB-GENE-5829000
Gene Symbol dna2 dna2.L dna2.S
Chromosome Chr07 chr7S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide RefSeq
Protein RefSeq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine dna2 dna2.L dna2.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards DNA2 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Dna2 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR dna2 ZFIN Ensembl
chicken
GEISHA DNA2 Ensembl
fruit fly
worm
WORMBASE
Publications
First Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex., Nature 1994  
Most Recent HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome., Proc Natl Acad Sci U S A 2018                                  
All View All Papers 2 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 0 term 0 term 22 terms
PANTHER dna2
KEGG Pathways K10742
KOG [L] DNA replication helicase
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
Dharmacon Dharmacon Dharmacon
Antibody Dna2 Ab1 Dna2 Ab1
Affymetrix 1.0 Str.40351.1.S1_at Xl.17390.1.S1_at
Affymetrix 2.0 Xl2.17390.1.S1_at

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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