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Summary Expression Gene Literature (49) GO Terms (10) Nucleotides (113) Proteins (22) Interactants (169) Wiki
XB-GENEPAGE- 5857844

Gene Symbol: mcm3

Gene Name: minichromosome maintenance complex component 3

Synonyms: Xmcm3 , mmcm3
Add Xenopus synonyms , Nomenclature history


Gene Function: DNA replication licensing factor, MCM3 component

Protein Function:
Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development.

Interactants: mcm2 (25) , mcm7 (14) , mcm4 (13) , mcm5 (12) , mcm6 (11) , cdc6 (8) , cdc45 (6) View All

OMIM Disease Associations:
 
Xenbase Gene ID XB-GENE-5857845 XB-GENE-5857895 XB-GENE-17343843
Genome X. tropicalis X. laevis L X. laevis S
Gene Symbol mcm3 mcm3.L mcm3.S
Chromosome Chr06 chr6L
Molecules tropicalis laevis .L laevis.S
Gene GBrowse 8.0 GBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 GBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide Refseq
Protein NCBI Protein TrEMBL Refseq Swiss-Prot TrEMBL
Genomic tropicalis laevis .L laevis.S
Genome Browser
GBrowse
tropicalis genome v8.0 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis .L laevis.S
Ensembl Ensembl
UniGene Str.4149 Str.87009 Xl.4509 Xl.14664 [+]
RNA-seq profile: Owens, Blitz et al. 2016 mcm3
Images 0 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis .L laevis.S
XenMine mcm3 mcm3.L mcm3.S
Phenotype tropicalis laevis .L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards MCM3 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Mcm3 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN mcm3 ZFIN Ensembl
chicken
GEISHA MCM3 Ensembl
fruit fly
FLYBASE Mcm3 Ensembl
worm
WORMBASE
Publications
First: Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication. [Nucleic Acids Res 1992]
Most recent: Protein phosphatase 2A and Cdc7 kinase regulate the DNA unwinding element-binding protein in replication initiation. [J Biol Chem 2014]
View All Papers 1 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis .L laevis.S
GO 6 terms 11 terms 0 term
EC adenosinetriphosphatase
PANTHER mcm3
KEGG K02541 K02541
KOG [L] DNA replication licensing factor, MCM3 component
Reagents tropicalis laevis .L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
geneservice/RZPD imagenes geneservice/RZPD imagenes
Antibody Mcm3 Ab1 Mcm3 Ab1
ORF mcm3 ORF1
Affymetrix 1.0 Str.4149.1.S1_at Xl.4509.1.S1_at
Affymetrix 2.0 Xl2.4509.2.S1_a_at

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