[provisional- machine annotated only] Gene Symbol: hdac6 [Predicted: Source is Human Entrez Gene] Gene Name: histone deacetylase 6 [Predicted: Source is Human Entrez Gene] Synonyms: hd6, jm21 Add Xenopus synonyms Gene Function: Histone deacetylase complex, catalytic component HDA1 Interactants: hdac3(2) , bmp2(1) , dnaja2(1) , dnajb1(1) , dnajb6(1) , hdac1(1) , hdac4(1) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002944619|PREDICTED: Xenopus (Silurana) tropicalis histone deacetylase 6-like (LOC100494844), partial mRNA GTGACCCCCACAAAGCAGGAGCTGCTGGGCGAGGCTGCGGGAGGCTCGGAGGCTGGAAACCCCCACATCGGGTTTGAGACTCTCATGGAGTCGATGGCGAACGAGTCCGGTGAGGGATTTGCAGTCACCCCGCTGCCTTGGTGCCCCCACTTGGGCTCTGTGAGTGCTGTGCCCCCGGCGGGTCTGGATGTGAGGCAGCTGTGTGCCCAGTGTGCCAGTGAGCTGGAGAACTGGGTCTGTCTGACTTGTTACCAGGTGCTGTGCGGCAGGTATGTCTCCCAACACATGCTGTGCCATGGACTTGCCTCTGGGCATCACCTTGTTCTCAGCTTCTCCGACCTGTCTGTGTGGTGCTACGGCTGTGAGTCCTACGTCCATCACCAGGCCTTGTTCCCGGCCAAATCTGCTGCCTACAGCTCCAAGTTTGGGGAGGAAATGCAATCGATGTAGAGGCTGCTGAGAGGAGTTGGGGGGCCCTGGGGGCCACACTCACCAAATTTCCCTTTTAAATATTTTATTTAATGTATAAAAACCTTTTAGCCAAA	Refseq >NM_001087017|Xenopus laevis histone deacetylase 6 (hdac6), mRNA GGGAAGAGAAGTGCACTTGTTTGTGTCTAGTGCCCCCCACAATGGCCTCTCCACAGGATCCTACAGCAGTGCCCCCCCGGGGGCTGACCGGTGCCTCCCGCTCTCCTGTGACCCCCGCATGCAGCATGGGGAAGCCCAGGAAGAAAGGTGCATCCCCCCAAGGCCCCCAGTCCCTGCAGGAAGTAAAGAAGAGGGGCCACAGGATGAAGCGCAGCCCTGACCAGCAGCTGTGTGACCAACTCGAGGGGCTGAATTTGTTGGCAGAGGCAGCCGTGCAAGGAACGGGACTGGTTTATGATGAGCAGATGGCACACAACTACTGTTTATGGGATGAAAACTTTCCTGAATGCCCAGGCCGTATCTGGGCTGTGAGAGACAAGATGGCTGAATACGGCCTGGCAGAGCGATGTGTGGCGGTGCCGGCTCGTGAAGCATCAGAGGAGGAAATCTTGCTCATTCACAGCCCCCAGTATGTGGCACTGATGAGATCCACTCAGAAAATGACCATGGATGAGCTTAGAGCTCTGTCTGACCGCTATGATTCGGTGTACTTGCACCCGACGTCTTTCACTTGCGCCTCTTTGGCCGTGGGCTCAGTGCTCCAGCTGGTGGATAGAGTTCAGCATGGGGAGATCCGCAATGGATTGGCTGTTGTCAGGCCTCCTGGACATCACGCACACACTGACCAGATGAACGGTTACTGCATGTTTAACCAGCTTGCTATTGCTGCCCGATACGCCCAACTGACATATGGTGCCAAACGGGTCCTAATTGTAGACTGGGACGTGCATCACGGTCAGGGCACACAGTTCATATTTGAGAGTGATCCCAGTGTCCTGTACTTTTCTGTCCATCGCTATGACAACGGGGGTTTTTGGCCCCATCTAAAAGAATCGGCCAGTTCAGCTGTGGGGAAGGAACGAGGAGAGCGATTCAATGTGAATGTGGCCTGGAACAAGACCAGAATGAGTGATGCTGATTATATCCACGTGTTCCTTAATGTCCTACTTCCTGTCGCCTACGAGTTCCAGCCTCACCTTGTGTTGGTAGCAGCTGGGTTTGACTCTGTGGTTGGAGACCCTAAGGGAGAGATGTCGGCCACCCCAGCGTGTTTCTCTCACCTCACTCACCTGCTGATGTCACTGGCACAGGGCAGACTCATTCTTTCACTAGAGGGTGGGTACAATCAGCGCTCATTGGCAGAAGGAGCCTGTGCATCTCTGAAAGCCTTACTGGGTGACCCGTGCCCAAGACTGACCCTGCCATCTGCACCCTGTCAAAGTGCCCTGGATTCAATGTCTGACACAATAAGTGCCCATTGCAGCTTATGGAAGATGCTGCAGGATTACGAGAGTGAAGGAGAGCCCATTATTGAACCCCAGAGTGCTAAAGATGGCCCCCCTGAGGGGACAGATGAGCCTCCTCTGGAGAAATTTCTAGAACAGGCAATGATCGAAGTGATGCGGAAAGTGCCAGAGCAGCGAACAGCGCTGGTGTATGATGAGCAAATGATGGAGCATCGCAATATGTGGGACTGTTATCACCCAGAGTCTCCACAGAGGATAAACCAGATATTTAAGCGGCACAAGGATCTGGGGCTGTTAGAACGTTGCAGTCGCCTTCCATCACGCTTGGCCACTCAGAAGGAGCTACAGATGTGCCACAGTCTCTCCTACATCCAGAAGATTGAGGCATCTGCTCACATGAAACCACGAGACCTGCACAGGCTGGGGGATGAGTACAACTCCATTTATATCAATTCCAAATCCTACCACAGTGCCCGGCTGGCAGCTGGCTCTACCTTCAATGTAGTGGAGGCCGTGGTTACAGGAAAGGCACAAAATGGAATTGGCATTGTTCGCCCTCCGGGTCATCATGCAGAACCAGGGGAAGCCTGTGGTTTCTGTTTCTTTAACACCGTGGCACTAGCTGCCCGCTATGCACAGAGACTGCAGAGCCAATCAGAGGATCCACTCAGAGTAATGATTTTGGATTGGGATGTACACCATGGCAATGGCACGCAGCACATCTTCCAGGAGGATGCCAGTGTGCTCTACATGTCCCTCCACCGATACGATGAGGGTCTCTTCTTTCCAAATTCAGAAGATGCATCACATGACAAGGTTGGCATTGGGAAGGGGGCAGGATACAATGTGAACATCCCTTGGAATGGCGGAAAGATGGGGGATGTGGAATATTTAATGGCGTTTCACAGAGTGGTGATGCCCATTGCTTATGAGTTTAACCCTCAGCTAGTTCTCATATCGGCTGGGTTTGACGCGGCCCGTGGGGATCCACTTGGGGGCTGCCAGGTGAGCCCTGAAGGTTATGCCCATATGACACACCTTCTGATGAGCCTGGCAGGTGGCAGAGTCATCCTGGTGCTAGAGGGTGGGTACAATCTCACATCCATCTCCGAGTCCATGGTTATGTGCACCCGATCGCTCTTGGGGGACCCCCCACCAGTTCTGTCTGACCTGCGACCTCCAAAATCATCAGCTTTGAACTCCGTTTGCAAAGTCCGTCAGGCACATCGCAAATACTGGCGCAGCCTTCGGCTAAATGTGGTAGGACCTCCCCCCAAGTCTACTCAGGGAGCAAAAAATCTCCAGCATTCCCCAATGAGGAACTCTCCCCGTAAAGGAAGATTTGCTGCAGAGGCTGGACCCTTAACAGAGAGCAAGATCTCTTCTCAAGGAGCTTCATCTCCAAAAAAAATCCCCTCAGAAGTGACAGTCACCCCCCTGGCATCACCACTGAGCTCAGTCTCCATAGAAGAGACACCTATCCCATTGATACCAGACAGCAAATTCTCCCCAGAAGAGGTAGCCAACCAATTTGTATCTGCAGAGACTGCTGTTCAGTTCGCTGCACCACAGTACAAGATGTCCACAGAGGAGGTAGCCAATAAGCTGGCATCACCTCAAGGACTGACATCACTTGAAAGTACAAGCAGTCAGCTGGTATCCAACAGGGAAGCGATTGCGCCAGCATGGGAACATGAAACCCCCAAATCTCCTCCCACCGCAGACAGCCAGAAAGTACCTATGGGAGGATTAGTAGCAGCAGAAGACATTGCAGATGCCCTAGCAGAGAGGGGCCTTACAATGGAGATATTGGGGTGCTCTGAGCAGCGAGAGAATGTGTGTAAATGTAAAGCATCTCCACAATCCTTGCAGCATGAGGACAAGTTATTAGACGTTCAGTCTCCAGGGGTGAGAATTGCATCCGGGAAAGAGAGTGAGGCACCAGTGCCCCCCTGTTCCACTGTTGAGGAAAGACCTTTAGAACAAATTCTCAGAGACTTGCAGTTGAGTGATGATGCGTCCAGCAGTTCCTCCATTGCCATGGCTCATACAGCTGACTTGGATCCTAGGGACAGAGCCATAAGGAAATCCTTTATCACTACAGGAAGAGACACTCCGGAGGAAGAGTATACAGAGGGCAGTTATATACAGGTGGCTAATGCACCACCCAATGAGCAGGAGCTGCTGGACGAGGCTGCGGGGGGCTCGGAAGCTGGAAACTCCACCATAGGCTTTGAGGTTTTTCTGAACTCTATGGAGGATGAGTCGGATGTGGGATTTGCAGTCATGCCGCTGTCCTGGTGTCCTCACTTGGGCTCTGTGTGTGCTGTGCCCCGGGATGGTGTGGATGTGAGCCAGCCGTGTGCCCAGTGTGGCAGTGAACTGGAGAACTGGCTCTGTCTGACTTGTTACCAGGTGCTGTGTGGCAGGTATGTCTCCCAACACATGCTGAGCCATGGACTCACCTCTGGACATCACCTTGTTCTCAGCTTCTCTGACTTGTCTGTGTGGTGCTACGGCTGTGAGTCCTATGTACATAACGAGGCCTTGTTTCCAGCCAAATCTGCTGCCTACAGCTCCAAGTTTGAGGAGTAGGAGGTAGACGCGATATAAGGGCTGCTGTTCCGGAGGGGCCTTTTTGCCAAATTTCCATTTTAAATATTTTATTTAATGTATAAAATCTTTTAGCCAAAAAAAAAAAAAAA
Protein		NCBI Protein >XP_002944665|PREDICTED: histone deacetylase 6-like, partial [Xenopus (Silurana) tropicalis] VTPTKQELLGEAAGGSEAGNPHIGFETLMESMANESGEGFAVTPLPWCPHLGSVSAVPPAGLDVRQLCAQCASELENWVCLTCYQVLCGRYVSQHMLCHGLASGHHLVLSFSDLSVWCYGCESYVHHQALFPAKSAAYSSKFGEEMQSM	Refseq >NP_001080486|histone deacetylase 6 [Xenopus laevis] MASPQDPTAVPPRGLTGASRSPVTPACSMGKPRKKGASPQGPQSLQEVKKRGHRMKRSPDQQLCDQLEGLNLLAEAAVQGTGLVYDEQMAHNYCLWDENFPECPGRIWAVRDKMAEYGLAERCVAVPAREASEEEILLIHSPQYVALMRSTQKMTMDELRALSDRYDSVYLHPTSFTCASLAVGSVLQLVDRVQHGEIRNGLAVVRPPGHHAHTDQMNGYCMFNQLAIAARYAQLTYGAKRVLIVDWDVHHGQGTQFIFESDPSVLYFSVHRYDNGGFWPHLKESASSAVGKERGERFNVNVAWNKTRMSDADYIHVFLNVLLPVAYEFQPHLVLVAAGFDSVVGDPKGEMSATPACFSHLTHLLMSLAQGRLILSLEGGYNQRSLAEGACASLKALLGDPCPRLTLPSAPCQSALDSMSDTISAHCSLWKMLQDYESEGEPIIEPQSAKDGPPEGTDEPPLEKFLEQAMIEVMRKVPEQRTALVYDEQMMEHRNMWDCYHPESPQRINQIFKRHKDLGLLERCSRLPSRLATQKELQMCHSLSYIQKIEASAHMKPRDLHRLGDEYNSIYINSKSYHSARLAAGSTFNVVEAVVTGKAQNGIGIVRPPGHHAEPGEACGFCFFNTVALAARYAQRLQSQSEDPLRVMILDWDVHHGNGTQHIFQEDASVLYMSLHRYDEGLFFPNSEDASHDKVGIGKGAGYNVNIPWNGGKMGDVEYLMAFHRVVMPIAYEFNPQLVLISAGFDAARGDPLGGCQVSPEGYAHMTHLLMSLAGGRVILVLEGGYNLTSISESMVMCTRSLLGDPPPVLSDLRPPKSSALNSVCKVRQAHRKYWRSLRLNVVGPPPKSTQGAKNLQHSPMRNSPRKGRFAAEAGPLTESKISSQGASSPKKIPSEVTVTPLASPLSSVSIEETPIPLIPDSKFSPEEVANQFVSAETAVQFAAPQYKMSTEEVANKLASPQGLTSLESTSSQLVSNREAIAPAWEHETPKSPPTADSQKVPMGGLVAAEDIADALAERGLTMEILGCSEQRENVCKCKASPQSLQHEDKLLDVQSPGVRIASGKESEAPVPPCSTVEERPLEQILRDLQLSDDASSSSSIAMAHTADLDPRDRAIRKSFITTGRDTPEEEYTEGSYIQVANAPPNEQELLDEAAGGSEAGNSTIGFEVFLNSMEDESDVGFAVMPLSWCPHLGSVCAVPRDGVDVSQPCAQCGSELENWLCLTCYQVLCGRYVSQHMLSHGLTSGHHLVLSFSDLSVWCYGCESYVHNEALFPAKSAAYSSKFEE

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.52523	Xl.8310
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	HDAC6
mouse		MGI	Hdac6	All(6) Targeted, knock Out(2) Targeted, other(4)
zebrafish		ZFIN	hdac6	4 Lines(s)

Publications
First:		A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation. [Mol Cell 2010]
Most recent:		HDAC activity is required during Xenopus tail regeneration. [PLoS One 2011]
		View All Papers

Functional Ontologies
GO: Molecular:		acetylspermidine deacetylase activity sugar binding
Biological:
Cellular Component:
EC:		acetylspermidine deacetylase
KOG:		[B] Histone deacetylase complex, catalytic component HDA1

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.27607.2.S1_a_at	Xl.8310.1.S1_at
Affymetrix 2.0			Xl2.8310.1.S1_at

Symbol legend[+]

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