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XB-GENEPAGE-5937935
Gene Symbol:
znrf3
Gene Name: zinc and ring finger 3
Synonyms:
( Gene Function: Predicted E3 ubiquitin ligase Protein Function
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E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (PubMed:22575959...[+]
Interactants:
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Diseases: External Links:
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Xenbase Gene ID | XB-GENE-5937936 | XB-GENE-17345453 | XB-GENE-5937954 | |||||
Gene Symbol | znrf3 | znrf3.L | znrf3.S | Chromosome | Chr1 | chr1L | chr1S | |
Molecules | X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genomic Sequence |
Version 10.0
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Version 9.1
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Version 9.1
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CDS |
Gene model
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Gene model
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Gene model
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Entrez Gene |
780325
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108717096
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735142
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mRNA |
RefSeq
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NCBI Nucleotide
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NCBI Nucleotide
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Protein
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Genomic |
X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genome Browser (Click image to open in Genome Browser)
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Genomic Synteny | Genomicus PANTHER | |||||||
Expression | Development Stages | Embryonic Tissues | Adult Tissues | |||||
Summary for |
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More Information |
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Data Mining | X. tropicalis | X. laevis.L | X. laevis.S | |||||
XenMine | znrf3 | znrf3.L | znrf3.S | |||||
Orthology |
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mouse |
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rat |
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zebrafish |
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chicken |
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fruit fly |
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worm |
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Publications | ||||||||
First |
Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin., Nat Commun 2013 ![]() |
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Most Recent |
The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer., Elife 2020 ![]() |
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All | View All Papers 1 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology | |||||||
Functional Ontologies | X. tropicalis | X. laevis.L | X. laevis.S | |||||
GO | 13 terms | 6 terms | 11 terms | |||||
PANTHER | znrf3 | |||||||
KEGG Pathways | K16273 | K16273 | K16273 | |||||
KOG |
[O] FOG: Predicted E3 ubiquitin ligase
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Reagents | X. tropicalis | X. laevis.L | X. laevis.S | |||||
CRISPRscan Tracks | znrf3 | |||||||
Morpholinos (on-target & off-target) | znrf3 MO1 , znrf3 MO2 | znrf3 MO1 | znrf3 MO2 , znrf3 MO1 | |||||
ORFs | znrf3 ORF1 | znrf3.S ORF1 | ||||||
Clones | Horizon Source BioScience | Horizon | Horizon Source BioScience | |||||
Plasmids | Addgene | Addgene |
Symbol legend:



