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Summary Expression Gene Literature (8) GO Terms (17) Nucleotides (88) Proteins (27) Interactants (290) Wiki
XB-GENEPAGE-5937935
Gene Symbol:
znrf3

Gene Name:
zinc and ring finger 3

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
Predicted E3 ubiquitin ligase

Protein Function :
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (PubMed:22575959...[+]



Interactants:
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Diseases: 


External Links:
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Xenbase Gene ID XB-GENE-5937936 XB-GENE-17345453 XB-GENE-5937954
Gene Symbol znrf3 znrf3.L znrf3.S
Chromosome Chr1 chr1L chr1S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 780325
108717096
735142
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. NCBI Protein NCBI Protein  More.. RefSeq Swiss-Prot  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine znrf3 znrf3.L znrf3.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards ZNRF3 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Znrf3 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Znrf3 Ensembl
zebrafish
ZFIN, AGR znrf3 ZFIN Ensembl
chicken
GEISHA ZNRF3 Ensembl
fruit fly
worm
Publications
First Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin., Nat Commun 2013                
Most Recent The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer., Elife 2020                                                                                                
All View All Papers 1 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 13 terms 6 terms 11 terms
PANTHER znrf3
KEGG Pathways K16273 K16273 K16273
KOG [O] FOG: Predicted E3 ubiquitin ligase
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks znrf3
Morpholinos (on-target & off-target) znrf3 MO1 , znrf3 MO2 znrf3 MO1 znrf3 MO2 , znrf3 MO1
ORFs znrf3 ORF1 znrf3.S ORF1
Clones Horizon Source BioScience Horizon Horizon Source BioScience
Plasmids Addgene Addgene

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