Gene Symbol: suv39h1 [provisional] Gene Name: suppressor of variegation 3-9 homolog 1 [provisional] Synonyms: kmt1a, suv39h Add Xenopus synonyms Gene Function: histone-lysine N-methyltransferase Interactants: ahnak(1) , bmp4(1) , cdc42(1) , cpsf4(1) , fgfr4(1) , hmg20b(1) , hnmt(1) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 4.1 JGI XT Genome 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002944399|PREDICTED: Xenopus (Silurana) tropicalis histone-lysine N-methyltransferase SUV39H1-like (LOC100492584), partial mRNA CCTCTAGTGACGTGCCTACAGATACAGCCAATGGCAGGAAGGGCTAGTTCGGCGCGCCGGGTGGGTGTAGCCAATGAGAGGAGAGGATGGGGAAGAGGACACGCCTCTCACTGTACAGCATGGCGGAAAATTCAAAGGGCGCGTTAGGCTGCAGGGTGCGGTGTCTGTCGTCGCAGTCGGAGCTGCAGGAGGTGTGTCGGGAGGAGCAGTTGTGCTGCGCTGATCTGGGTGTCACTCGCAAGAACCTCAGTGACTTCGAAGTGGAGTATCTGTGCGACTACAAGAAAGTGCAGGATCAGGAGCTGTACCTGGTGAAGTGGAAATATTACCCCCATTCGGAGAGCACGTGGGAGCCCCGACATCACCTGAAGTGCAGCAGTGTCCTCAAGCGCTTCCACCTGGACCTGGAGCAGGAGCTGCTGCGCAGAGCAAAGGCTTCTGGGGGAAGGAAGAGGGCGGCGGCACGGTGGCCCCGCAGGTTGGACCAGAGCCTCTCCCATTACTTAGTGCTAAAGGCCAAGCAGCGCCAGCGCCTGCGCCAGTGGGAGGAGCAACTCAACGCCAAGCGCTCCCATCGGGGCCTCATCCTGGTGGAGAATGAAGTGGACCTGGAGGGGCCGCCCCGGGACTTTGTGTACATCAATGAGTACAGGGTGGGCGAGGGGGTGGCCGCGGGGCAAATATCAGCCGGGTGCAAGTGCCGGGACTGTTCAGCGGATGAGGGGGGCTGCTGCCCGGGGGCCTTCCTGCACAAAAGGGCCTACAATGACGAGGGGCAGGTGAAGGTGAAGCCCGGCTTCCCGATCTATGAATGTAACTCCCGCTGTCGCTGTGGGCCCTCCTGCCCCAACCGCGTGGTACAGAAGGGAATCCAGTACAAATTCTGTATATTCAGGACCCCCAATGGCAGAGGGTGGGGCGTGCGTACGCTGGAGAAGATCCGCAAGAACAGCTTCGTCATGGAGTATGTGGGGGAG	Refseq >NM_001091423|Xenopus laevis suppressor of variegation 3-9 homolog 1 (suv39h1), mRNA CGCCGGGGAGTTTTAGCCAATGAGAGGAGAGGATGGTTAGAAGAACACGCCTGTCATCGTACAACATGGCGGAAAATTCAAACGGAGCGCTAGGCTGTGTGGTGCGATGCCTCTCATCAGAATCAGAACTACAAGAGCTGTGTCGGGAGGAGCAGCTGTGCTGTGCTGAGCTGGGTGTCACTCGCAAGAACCTCAGTGATTTTGAAGTGGAATATCTGTGGAACTACAAGAAAGTGCAGGACCAGGAGCTGTACCTTGTGAAGTGGAAATATTACCCTGATTCTGAAAGCACCTGGGAACCCCGACATCACCTCAAGTGCAACAATCTCCTGAAGCAATTCCATTTGGACCTGGAGCGGGAGCTGCTACGGCGAGCAAAGGCTGCTGGGACAAAGAAGACAGCAGTGAGGTGTCCCCGCAGGTTGGACCAGAGCCTTTCCCACTACTTAGTGCTAAAAGCCAAGCAGAGGAAGCGCCTCCGCCAGTGGGCACAGCAACTCAATGCCAAGCGCTCCCACCTTGGCCTAATCCTGGTGGAGAATGAAGTGGACCTGGAGGGCCCACCCCGTGACTTTGTGTACATTAATGAGTACAGGGTGGGTGAGGGGGTGACAATCAACCGAATTTCAGCAGGATGCAAATGCCGAGACTGTTTTTCAGATGAGGGGGGCTGCTGTCCAGGGGCCTTCCAGCACAAAAAGGCCTACAATAATGAGGGGCAGGTGAAGGTGAAACCTGGCTTTCCAATTTACGAATGTAACTCCTGCTGCCGCTGTGGCCCCTCCTGTCCTAACCGTGTGGTTCAAAAGGGAATCCAGTACAAATTCTGTATATTCAGGACGTCAGATGGGAGAGGGTGGGGTGTGCGTACGCTGGAAAAGATCCGCAAAAACAGCTTTGTCATGGAGTATGTGGGAGAGATAATAACCTCTGAAGAAGCGGAGCGGAGGGGCCAAATCTATGACCGCCAAGGAACCACCTACCTGTTTGACCTGGATTATGTGGAAGATGTTTATACAGTGGATGCTGCTCGTTATGGGAATATATCACACTTTGTAAACCACAGTTGTAAGCCGAACCTTCAGGTGTACAACGTCTTTATCGATAACCTAGATGAAAGATTACCCCGTATTGCTTTTTTTGCAACCCGAACAATCCGAACAGGGGAGGAGCTGACATTTGACTACAATATGCAGGTGGACCCAGTGGATGTGGAAAGTAGCAAAATGGATTCTAACTTTGGCATAGCCGGTCTCCCTGCATCTCCCAAGAAGCGAGTGCGGGTGGAATGCAAGTGTGGAGTAAGCAGCTGCCGCAAGTACCTCTTCTGAGAGATGGACCAGGATGTCCCTGTACCACCTGAACTTGGTTGGTTCTTACACTGCACTTAAATTATTTGCTGCCCCAGACAGCAAGATGAGAACATTACCACCCTTCACCATGAGAGCAGTTCCTAATCCCTACCCCTAGTGAGATCCTTGCTTGCAAAGCATTAATTGCACAGTACTGACCCCATGAAATATTGGTGCTAAAGCCTTAGAGAGGCTTGAGATTTGCTGCCTGGGCCTCATCTGTGAATTGCTCCATCCTTGTGTGCTAGTGTTACTGGCCCAGAATGTGTTTTTACTTGAACTTCCTGTTCCCTTAAACTGTATGTGATGCACCAGAGGGAAGGCGGACTATGAAATGATACCCACTTCCTTCTAATAGGTGCCTGCCTGTTATGGGTTTTTATTGCATTTTCTGTGTTTTTATGCATGGGGAAGATTACCATCGGATTTGTGTAGTGACTGGGTTCTGCAACTTATCAGTGGCTTATGTGGCCCAGACCTGGATTCTCTGCTCACCAATTGTGGTTTCAAGCTGTACCCACAACTAATATATGTCAGGCACTGTGTCCCTACACTAATTCTTCCCTCTCTGGAACAAAAGGGGCGCGTTTTTATTCTTGTTTTTATTATTGTCTAAACCCGAACCATTGTTCTTTTTGTGACCACCTGGCTCCTGTGTTCGGACTGTGTATGTATGGCTCCTGTCCTTTAACATTTTATACATGTCCACTTTGTGTTTATAAATAATACATTGTTTTAAAAAAAAAAAAAAAAAAAAAAAA
Protein		NCBI Protein >XP_002944445|PREDICTED: histone-lysine N-methyltransferase SUV39H1-like, partial [Xenopus (Silurana) tropicalis] MGKRTRLSLYSMAENSKGALGCRVRCLSSQSELQEVCREEQLCCADLGVTRKNLSDFEVEYLCDYKKVQDQELYLVKWKYYPHSESTWEPRHHLKCSSVLKRFHLDLEQELLRRAKASGGRKRAAARWPRRLDQSLSHYLVLKAKQRQRLRQWEEQLNAKRSHRGLILVENEVDLEGPPRDFVYINEYRVGEGVAAGQISAGCKCRDCSADEGGCCPGAFLHKRAYNDEGQVKVKPGFPIYECNSRCRCGPSCPNRVVQKGIQYKFCIFRTPNGRGWGVRTLEKIRKNSFVMEYVGE	Refseq >NP_001084892|histone-lysine N-methyltransferase SUV39H1 [Xenopus laevis] MAENSNGALGCVVRCLSSESELQELCREEQLCCAELGVTRKNLSDFEVEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHLKCNNLLKQFHLDLERELLRRAKAAGTKKTAVRCPRRLDQSLSHYLVLKAKQRKRLRQWAQQLNAKRSHLGLILVENEVDLEGPPRDFVYINEYRVGEGVTINRISAGCKCRDCFSDEGGCCPGAFQHKKAYNNEGQVKVKPGFPIYECNSCCRCGPSCPNRVVQKGIQYKFCIFRTSDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTTYLFDLDYVEDVYTVDAARYGNISHFVNHSCKPNLQVYNVFIDNLDERLPRIAFFATRTIRTGEELTFDYNMQVDPVDVESSKMDSNFGIAGLPASPKKRVRVECKCGVSSCRKYLF UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase JGI UCSC			Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene			Xl.46583
Unigene EST Profile			EST Profile
GEO data			GEO
Images		31 expression image(s) for tropicalis and laevis

Phenotype		tropicalis	laevis
Smith Morpholino Screen		tegg137c14

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	SUV39H1
mouse		MGI	Suv39h1	All(1) Targeted, other(1)
zebrafish		ZFIN ZFIN	suv39h1a suv39h1b

Publications
First:		Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor. [Mol Cell Biol 2002]
Most recent:		Remodeling of ribosomal genes in somatic cells by Xenopus egg extract. [Biochem Biophys Res Commun 2013]
		View All Papers 1 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		chromatin binding histone-lysine N-methyltransferase activity zinc ion binding
Biological:		chromatin assembly or disassembly chromatin modification
Cellular Component:		chromatin nucleus
EC:		histone-lysine N-methyltransferase
KOG:		[BK] Histone H3 (Lys9) methyltransferase SUV39H1/Clr4, required for transcriptional silencing

Reagents		tropicalis	laevis
Clones			open biosystems
			geneservice/RZPD imagenes
Affymetrix 1.0			Xl.12013.1.A1_at
Affymetrix 2.0			Xl2.46583.1.S1_at

Symbol legend[+]

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