Gene Symbol: sfrp5 Gene Name: secreted frizzled-related protein 5 Synonyms: sFRP-5, XsFRP5, frp5 Add Xenopus synonyms Gene Function: modulator of Wnt signaling Interactants: hhex(8) , gcg(5) , ins(5) , ptf1a(5) , neurod1(4) , pdx1(4) , sst(4) View All	1/3

Molecules		tropicalis	laevis a		laevis b
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene		Entrez Gene
mRNA		Refseq >NM_001004846|Xenopus (Silurana) tropicalis secreted frizzled-related protein 5 (sfrp5), mRNA GGCAACAAGCACAGACTTTTAATGCACTTCTTGTGCAGCATACAAGCTCCAGCTGTCTCTCCTTACAGCTGCAGAAAGGTCTAGCGAGACTGAAAGGGAGAGTGAAATAGTAGGAAGGAATGAGAAAGCCAGGCCACTGCTTGGTAACTCTTTAAACCACAAAGTGGGAGGACTTTATTTTTCTTAGAATAATATATATTATTTTTTTTTTTTTTAATTATTCAGAAATCCTATATCAATAGGATAAGTCTTTTGGGTTTAAATATTTATACATTTTATTTTGTCCACCTTTGGGGGAAATCATGCGATTTCAGTGGAATATTTTGGCTTGGGTGAATTCTTTAATACTTGGGCTGGTTCTTTGGAGCTCTGCAGAAGAATATGATTATTACAGCTGGCAGTCGGACAACTTCCAGAACGGACGGTTCTATACTAAACAGAGTCAATGCATAGACATCCCTTCGGATCTCCATCTCTGCCATAATGTTGGCTATAAAAAAATGCGATTGCCTAATTTGCTGGACCACGAGACCATGCCTGAGGTGAAGCAGCAAGCCAGCAGCTGGGTGCCTCTACTGGCCAAGCGGTGTCATCGAGATACTCAGCTCTTCCTCTGCTCCCTTTTTGCTCCCATTTGCTTGGAAAGACCCATTTATCCATGCCGGTCACTATGCGAGGTAGTGCGGGACAGCTGTGCCCCAGTTATGGAATCCTATGGTTTCCCTTGGCCAGAGATGTTGAACTGCAATAAATTCCCTCTTGATAATGATCTGTGCATCACTGTGCAGTTTGGCAGCAAACAAGTCACTCAGCCACCAGTGACCAAGATTTGCACTCAGTGTGAAATAGAACAGAAGTCCGAAACAATGAGGGTGCAACTTTGTGCAAGTGACTTTGTGCTACGGATGCGCATTAAAGAAGTTAAGATTGAGAATGGAGATCGAAAACTCATCGCTGCTCAGAAGAAGAAAAAGGTCCTCAAAGCAGGGAAGCTAAAGAGGAAAGAATTCCGCAAGCTGGTTCTGTATATTAAGAACGCGGCAAGTTGCCCATGTCCTCAGCTCGACAACCTAAGTGGAAGCTTTCTTATCATGGGCCGTAAAGTGGACAATAAACTTCTTCTTACAGCCATCTACAAGTGGGACAAGAAAAGCAAAGATATGAAGTATGCAGTGAATTTCATGTACTCCTATCCATGCTCTGACACTATTTCCCACGGCACCGGATCACACTTAGGCTCCTTCCGCTAAGACTGTCGTCTGTAGACTTTAAAGTGCCACCATCACCCAGCCTTACCAAATGGATTTTATATTATAGTAATAGCAATAACTTAGCATACTCACTTGTGTTGAAAACCTCTTGTGAAGATGGTGTTGAAATTTTAAAAAAAGCAATACTAGGGTATGTTGTAGTATGTTGAATGACGAAAAATAAAAGGGTGAAGAATGTGATGTATTTGTGGGGAAAAGACACTGAGAAAATGGGCTTGGTATAAACATGGACTGGATATGGTTGAAGAAGGACACTACAACAATAGGTTTGGAAGACTGGATTGCCACGGTTGTTGAGAGCAGTAGTTTATCATTCCCTTAGAAGAAACACATTATTATTGAGACTTAAATCACTGCTGGTAGTAACATGAACCATACTTTCTGAAGGACTGATGAATCGTGACTAGGCTGCCCCACTTTGTCATAACGTATCCTCTGCAGGATGTCAAGTTAGCATGCCTTGCAATTTCATCTTTATATATAGGTGCTTGCTACATCTGTAAACAGCATTATATCTCATCATTCATAGCCATCACCTTTTTTTTTTTTCAATTTCTGTGTCAGATTTTATTTATAGGAAATATTCCATGTTAACGTTGAAGAAATACATAAAATTGATTCCCAAGTCGCGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001090477|Xenopus laevis secreted frizzled-related protein 5 (sfrp5-a), mRNA GGCACGAGAAGAGTTGGGAAGCAGGCACCAGGCACAGACTTTTAATGCACTTCTTGTGCAGCATACAAGCTCCAGCTGTCTCTCCTTACAGCTGCAGAAAGGTCTAGCGAGACTGAAAGGGAGAGTGAAATAGTAGGAAGGGATGAGAAAGACAGGCCACTGCTTGGTAACTATTTAAACCAGAAATTGGGAGGACTTTGTTAGATTAATATATGCTATTTTATTTGTTATAACTATTTACACCAGAAATCCTATATCCGTAGGGATAAGCTTTTATTTATACATTTTATTTTGCATTGGCTTTTTCCACATTTGGGAGAAATCATGCGATTTCAGTGGAATATTTTGGCTTGGGTGAATTCTGTACTGCTTGGGCTGGTTCTTTGGAGCTCTGCAGAAGAATATGACTATTACAGCTGGCAGTCAGACAACTTCCAGAACGGACGGTTCTACACTAAACAGAGCCAATGCATAGACATCCCTTCGGATCTCCATCTCTGCCATAACGTTGGGTATAAAAAGATGCGGCTGCCTAATTTGCTGGACCACGAGACCATGCCTGAGGTGAAACAGCAAGCCAGCAGCTGGGTGCCTCTGCTGGCCAAGCGATGTCATCGAGATACTCAGCTCTTCCTCTGCTCCCTTTTTGCTCCAATTTGCTTGGAAAGACCCATTTACCCATGCCGGTCCCTATGCGAGGTAGTGCGTGACAGCTGTGCCCCAGTTATGGAATCCTACGGTTTCCCTTGGCCTGAGATGTTGAACTGTAATAAATTCCCTCTTGATAATGATCTGTGCATCACTGTGCAGTTTGGCAGCAAACAAGTCACCCAGCCGCCAGTGACCAAGATCTGCACTCAGTGTGAGATAGAGCAGAAGTCTGAAACAATGAGGGTGCAACTTTGTGCAAGTGACTTTGTGCTACGGATGCGTATTAAAGAAGTTAAGATCGAGAACGGAGACCGTAAGCTCATCGCTGCGCAGAAAAAGAAAAAGGTCCTTAAAGCAGGGAAGCTAAAGAGGAAAGAATTCCGCAAGCTGGTTCTGTATATTAAGAATGCTGCAAGTTGTCCATGTCCACAGCTTGATAACCTAAGTGGTAGCTTCCTTATCATGGGTCGTAAAGTGGACAATAAACTTATTCTGACGGCCATCTACAAGTGGGACAAGAAAAGCAAAGATATGAAGTATGCAGTGAATTTTATGTACTCCTATCCATGCTCTGACACTATTTCCCATGGCACTGGATCACACTTGGGTTCCTTCCGTTAAGACTGTCATCTGTAGACTTTAAGTGCCACCATCGCCCAGCCTTACCAAATGGATTTTATATTATAGTAATAGCAATAACTTAGCATACTCACTTGCATTGAAAAACCTCTTGTGAAGATGGTGTTAACATTTTAAAAAAAAAGCAATACTAGGGTATGTTGTAGTATGTTGAGTGACAAAAATGAAAGGGTGAAGAATGTGATGTATGTAAGGGGAAAAGACACGGAATGAGATTTTCCATTGAGTTTGGTATAAACATGGACTGGGTATGGTTTAAGAAGGACACTACAACAATAGCTTTGGAAGACTGGATTGCCGAGAGCCGTAGTCTATCATTCCTCTAGAAGAAACACATTATTATTGAGACTTAAATCACTGCTGGTAGTAACATGAACAATGTTTTCTGAAGGACTGATGAATCGTGACTAGGCCGCCCCACATTGTCATAACTTATCCTTCTGAAGGATGTCAAGTTAGCATGCCTTGAAATTTCATCTTTATATATAGGTGCTTGCTACATCTGTAAACAACATTATATCTCATCATTCATAGCCATCACATGTTTTTTTTTTTTTTCTGTCAGATTTTATTTATAGGAAATATTCCGTGTTAACGTTGAAGAAAATACATAAAATTGATTCCCAAGTCACGAAAAGAGTTGAGCTGTGTGCCCGAGAGAGAAACCGGTTTGCTCAGTGTTCCATTGTTGATATTTTTTTTTTCTAATTTAAAATGAAAGAAGCTGAAAAGAAAAACCAGGCTATATAAATCTATATAAAAGAAAGTTTTTCTCAATGTCATTTAACAAAGAAGTAAAGATGTTCACAAGCTGGCAGCACTGCTTGAATGAAATGTTCCTAATTATATCTGTGCATCTTTATCCACGGGCATAATAGAAACACCACTGTAATACTTGCTTAATCCCTGAGCCCAGATTGATCACACTAATTTAGTGGAGCTGATTTATTCTGTACCACTCTGTTAATGCATATGGGGTTGTTACAGTGATGAGCCAGTACTATGTGCTAGGTCACTTACTGCTGGATGTTGTTAGGTATGCTTCTCTGCTTCTGTATAGTGGTCTAGACCCCATGAAACAACACAAAAACAACACAAAAACAACACAAAAAGAGCAGGTCATATTGTTTTGCATGTAGCATCCACCTTACATGAGCATTGACCTGCAGAGAGCAAAGGGACTTATTTATGTGTGCCGTCCACCGAAATGTATTACATGGAAATAGCTACATAAATTATTGAGCATCAGGCCATTGGGCAATTGATTAAAAAAATTAATGGAGAAGGAAAGCTATTAAGCAGTTTCTTGCCAATAGATTAGCCACAATAGTGCAAGCTAGAACGCTATATTTATTCTGTAGAATGCTTTACCATATCCGAGTAGACAGCTCTAGAAGCTCTCTCTCTGTTTGTTTAGGATAGCAGTTGCCATATTAGCTTGTGACATAACTTCCTGCTTGAGTCTCTGTCTGCTCGTTCATAGCTCTGGGCTTAGATTACAGCAGGGAGGTGAGAAGGGAGGCCTAGAGGAAGAGAGCAGCAAACTGAGCATGCTCAAGCCCAAGCCCTGGAGGTTCAAGCTGAAAGAAGGAAGTCTGATACAGAAGCCCATGTGTATCAAATAAAAGAAAAGAAATGTGGTGTTTATTTTGATAGAGGACCCTGAGCAGCATTCATTTGAGGGGATACTGGTGTATTTATATAGACCTTTCTAATAAAGCTTACTTAACCTTTAAAAAAAAAAAAAAAAAAA		Refseq >NM_001094505|Xenopus laevis secreted frizzled-related protein 5 (sfrp5-b), mRNA TGCACTTCTTGTGCAGCATACAAGCTCCAGCTGTCTCTCCTTACAGCTGCGGAAAGGTCTAGCGAGACTGAAAGGGAGAGTGAAATAGTGGGAAGGAATGAGAAAGACAGGCCACTGCTTGGTAACTCTTTAAACAAGAAATTGGGAGGACTTTATTTCTGTTAGATTAATATATGTTATTTTAATTTTTTTTTTGTAAAACTATTAATACCAGAAATCATATATCAGGAGGATAAGCCTTTGGGTTAAATATTTATAAACATTATTTTGCATTGCATTTACCACTTTTTGGAGAAATCATGCGATTTCAGTGGAATATTTTGGCTTGGATGAATTCTTTACTACTTGGGCTGGTTCTTTGGAGCTCTGCAGAAGAATATGACTATTACAGCTGGCAGTCGGACAACTTCCAGAATGGACGGTTCTACACTAAACAGAGTCAATGTGTAGACATCCCTTCGGATCTCCATCTCTGCCATAATGTTGGCTATAAAAAAATGCGACTGCCTAATTTGCTGGACCATGAGACCATGCCTGAGGTGAAACAGCAAGCCAGTAGCTGGGTGCCTCTGCTGGCCAAGCAATGTCATCGAGATACTCAACTCTTTCTCTGCTCCCTTTTTGCTCCAATTTGCTTGGAAAGGCCCATTTATCCATGCCGGTCATTATGTGAGGTAGTGCGTGACAGCTGTGCTCCAGTTATGGAATCCTATGGTTTCCCTTGGCCAGAGATGTTGAACTGCAATAAGTTCCCTCTTGATAATGATCTGTGCATCACTGTGCAGTTTGGCAGCAAACAAGTCACTCAGCCACCAGTGACCAAGATCTGCACTCAGTGTGAGATAGAACAGAAGTCTGAAACAATGAGGGTGCAACTTTGTGCAAGTGACTTTGTGCTACGGATGCGTATTAAAGAAGTTAAGATTGAGAACGGAGATCGTAAGCTAATCGCTGCTCAGAAAAAGAAAAAGGTGCTTAAAGCAGGGAAGCTAAAGAGGAAAGAATTCCGCAAGTTGGTTCTGTATATTAAGAATGCTGCAAGTTGTCCATGTCCACAGCTTGACAACCTAAGTGGGAGCTTTCTTATCATGGGGCGTAAAGTGGACAATAAACTTATTCTTACAGCCATCTACAAGTGGGACAAGAAGAGCAAAGATATGAAGTATGCAGTGAATTTTATGTACTCCTATCCATGCTCTGACACTATTTCCCATGGCACTGGATCACACTTGGGTTCCTTCCGCTAAGACTGTCATCTGTAGACTTTTAAGTGCCACCATCGCCCAGCCTTACCAAATGGATTTTATATTATAGTAATAGCAATAACTTAGCATACTCACTTGTGTTGAAAACCTCTTGTGAAGATGGTGTTAAACTTTAAAAAGCAATACTAGGGTATGTTGTAGTATGTTGAATGACAATTACGAAAGGGGGATGAATGTGATGTATTTGAGGGGAAAAGGCATTGAATTGAGAAAATGGAATCTTCAGTTGAGTTTGGCATAAACATAGACTGGATATGGTTGAAGAAGGACACTACAACAATAGCTTTGGAAGACTGGATTGCCACGATTGTTGAGAGCCGTAGTTTATCATTCCCTTAGAAAAAACACATTATTATTGAGACTTAAATCACTGCTGGTAGTAACACAAACAATATTTTCTGAAGGACTGATGAATTGTCATAACTTATCCTTCTGAAGGATGTCAAGTTAACATGCCTTGAGATTTCATCTTTATATATAGGTGCTTGCTACATCTGTAAACAACATTATATCTCATAATTCCTAGCCATCACATTTTTTTTTTTTGTGTCAGATTTTATTTATAGGAAATATTCCATGTTAACTTTGAAGAAATACAAATACATAAAATTGATTCCCAAGTCACAAAAAGAGTTGACCTGTGTCCCCGCGAGAGAAACCAGTCTGCTCAGTGTTCCATTGTTAATATTTTTTTCTCTGATTTAAAATGAAAGAAGCTTGATAAAAACAGGCTATATAAATCTATATAAAAGAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001004846|secreted frizzled-related protein 5 precursor [Xenopus (Silurana) tropicalis] MRFQWNILAWVNSLILGLVLWSSAEEYDYYSWQSDNFQNGRFYTKQSQCIDIPSDLHLCHNVGYKKMRLPNLLDHETMPEVKQQASSWVPLLAKRCHRDTQLFLCSLFAPICLERPIYPCRSLCEVVRDSCAPVMESYGFPWPEMLNCNKFPLDNDLCITVQFGSKQVTQPPVTKICTQCEIEQKSETMRVQLCASDFVLRMRIKEVKIENGDRKLIAAQKKKKVLKAGKLKRKEFRKLVLYIKNAASCPCPQLDNLSGSFLIMGRKVDNKLLLTAIYKWDKKSKDMKYAVNFMYSYPCSDTISHGTGSHLGSFR	Refseq >NP_001083946|secreted frizzled-related protein 5 precursor [Xenopus laevis] MRFQWNILAWVNSVLLGLVLWSSAEEYDYYSWQSDNFQNGRFYTKQSQCIDIPSDLHLCHNVGYKKMRLPNLLDHETMPEVKQQASSWVPLLAKRCHRDTQLFLCSLFAPICLERPIYPCRSLCEVVRDSCAPVMESYGFPWPEMLNCNKFPLDNDLCITVQFGSKQVTQPPVTKICTQCEIEQKSETMRVQLCASDFVLRMRIKEVKIENGDRKLIAAQKKKKVLKAGKLKRKEFRKLVLYIKNAASCPCPQLDNLSGSFLIMGRKVDNKLILTAIYKWDKKSKDMKYAVNFMYSYPCSDTISHGTGSHLGSFR		Refseq >NP_001087974|secreted frizzled-related protein 5 precursor [Xenopus laevis] MRFQWNILAWMNSLLLGLVLWSSAEEYDYYSWQSDNFQNGRFYTKQSQCVDIPSDLHLCHNVGYKKMRLPNLLDHETMPEVKQQASSWVPLLAKQCHRDTQLFLCSLFAPICLERPIYPCRSLCEVVRDSCAPVMESYGFPWPEMLNCNKFPLDNDLCITVQFGSKQVTQPPVTKICTQCEIEQKSETMRVQLCASDFVLRMRIKEVKIENGDRKLIAAQKKKKVLKAGKLKRKEFRKLVLYIKNAASCPCPQLDNLSGSFLIMGRKVDNKLILTAIYKWDKKSKDMKYAVNFMYSYPCSDTISHGTGSHLGSFR

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis a		laevis b
UniGene		Str.5261	Xl.49099		Xl.85058
Unigene EST Profile		EST Profile	EST Profile		EST Profile
GEO data			GEO		GEO
Images		66 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	SFRP5
mouse		MGI	Sfrp5	All(5) Targeted, knock Out(2) Chemically Induced(1) Targeted, other(2)
zebrafish		ZFIN	sfrp5

Publications
First:		Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium. [Hum Mol Genet 1999]
Most recent:		Functional analysis of Rfx6 and mutant variants associated with neonatal diabetes. [Dev Biol 2011]
		View All Papers 6 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		transmembrane receptor activity
Biological:		multicellular organismal development
Cellular Component:		membrane
EC:
KOG:		[T] Smoothened and related G-protein-coupled receptors

Reagents		tropicalis	laevis a		laevis b
Clones		open biosystems	open biosystems		open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes		geneservice/RZPD imagenes
Affymetrix 1.0		Str.5261.1.S1_at	Xl.21815.1.S1_at
Affymetrix 2.0			Xl2.21815.1.S1_at		Xl2.49099.1.S1_at

Symbol legend[+]

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