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Summary Expression Gene Literature (1) GO Terms (9) Nucleotides (166) Proteins (21) Interactants (198) Wiki

Gene Symbol: suv39h2

Gene Name: suppressor of variegation 3-9 homolog 2

Synonyms: kmt1b
Add Xenopus synonyms , Nomenclature history

Gene Function: histone methyltransferase

Protein Function:
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes.

Interactants: acbd6 (1) , actr6 (1) , aftph (1) , ahnak (1) , ap1m1 (1) , ap1m2 (1) , ap2m1 (1) View All

OMIM Disease Associations:
Xenbase Gene ID XB-GENE-852675 XB-GENE-866435 XB-GENE-17331508
Genome X. tropicalis X. laevis L X. laevis S
Gene Symbol suv39h2 suv39h2.L suv39h2.S
Chromosome Chr03 chr3L chr3S
Molecules tropicalis laevis .L laevis.S
Gene GBrowse 8.0 GBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 GBrowse 7.2 GBrowse 6.0 GBrowse 9.1
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq NCBI Nucleotide
Protein Refseq Swiss-Prot Refseq TrEMBL
Genomic tropicalis laevis .L laevis.S
Genome Browser
tropicalis genome v8.0 gene model
laevis genome v9.1 gene model
laevis genome v9.1 gene model
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis .L laevis.S
Ensembl Ensembl
UniGene Str.423 [+] Xl.70352 [+]
RNA-seq profile: Owens, Blitz et al. 2016 suv39h2
Images 2 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis .L laevis.S
XenMine suv39h2 suv39h2.L suv39h2.S
Phenotype tropicalis laevis .L laevis.S
Smith Morpholino Screen tegg055l20      
MOD Entrez Gene Genetic Phenotypes Gene Expression
OMIM:Gene, HGNC, GeneCards SUV39H2 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
MGI Suv39h2 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
GEISHA SUV39H2 Ensembl
fruit fly
First: Defining synphenotype groups in Xenopus tropicalis by use of antisense morpholino oligonucleotides. [PLoS Genet 2006]
Most recent:
View All Papers 1 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis .L laevis.S
GO 8 terms 4 terms 0 term
EC histone-lysine N-methyltransferase
PANTHER suv39h2
KEGG K11419 K11419
KOG [BK] Histone H3 (Lys9) methyltransferase SUV39H1/Clr4, required for transcriptional silencing
Reagents tropicalis laevis .L laevis.S
GE Dharmacon GE Dharmacon GE Dharmacon
geneservice/RZPD imagenes geneservice/RZPD imagenes
Morpholino suv39h2 MO1 suv39h2 MO1 suv39h2 MO1
Affymetrix 1.0 Str.423.1.S1_at [+] Xl.11673.1.A1_at
Affymetrix 2.0 Xl2.11673.1.S1_at [+]

Symbol legend[+]

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