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Summary Expression Gene Literature (0) GO Terms (9) Nucleotides (112) Proteins (21) Interactants (0) Wiki
XB-GENEPAGE- 853379

Gene Symbol: setdb1

Gene Name: SET domain, bifurcated 1

Synonyms:
Add Xenopus synonyms , Nomenclature history

Gene Function: histone methyl transferase

Protein Function:
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing.

Interactants:

OMIM Disease Associations:
 
Xenbase Gene ID XB-GENE-853380 XB-GENE-866480 XB-GENE-17337298
Genome X. tropicalis X. laevis L X. laevis S
Gene Symbol setdb1 setdb1.L setdb1.S
Chromosome Chr08 chr8L chr8S
Molecules tropicalis laevis .L laevis.S
Gene GBrowse 8.0 GBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 GBrowse 7.2 GBrowse 6.0 GBrowse 9.1
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq Refseq Swiss-Prot
Genomic tropicalis laevis .L laevis.S
Genome Browser
GBrowse
tropicalis genome v8.0 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis .L laevis.S
Ensembl Ensembl
UniGene Str.4156 Xl.54988
RNA-seq profile: Owens, Blitz et al. 2016 setdb1
Images 0 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis .L laevis.S
XenMine setdb1 setdb1.L setdb1.S
Phenotype tropicalis laevis .L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards SETDB1 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Setdb1 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN setdb1a setdb1b ZFIN Ensembl
chicken
GEISHA MLLT11 Ensembl
fruit fly
worm
WORMBASE
Publications
First:
Most recent:
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Functional Ontologies tropicalis laevis .L laevis.S
GO 0 term 9 terms 0 term
EC histone-lysine N-methyltransferase
PANTHER setdb1
KEGG K11421
KOG [B] Predicted histone methyl transferase
Reagents tropicalis laevis .L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
geneservice/RZPD imagenes geneservice/RZPD imagenes
Affymetrix 1.0 StrJgi.2163.1.S1_at [+] Xl.16848.2.A1_x_at [+]
Affymetrix 2.0 Xl2.16848.1.S1_at [+]

Symbol legend[+]

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