Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (2) GO Terms (11) Nucleotides (56) Proteins (23) Interactants (55) Wiki
XB-GENEPAGE-946666
Gene Symbol:
lrrc6

Gene Name:
leucine rich repeat containing 6

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
Protein phosphatase 1, regulatory subunit, and related proteins

Protein Function :
May play a crucial role in regulating cilia motility in pronephric tubules, cloaca and neural tube. May be required for establishing left-right asymmetry of the body plan; controls cell fate and conver...[+]


InterPro :
U2A' phosphoprotein32A C , Leu-rich rpt , LRR dom sf , Golgin A 7/ERF4

Interactants:
Loading ...

Diseases: 


Disease Ontology:
primary ciliary dyskinesia 19

OMIM:
CILIARY DYSKINESIA, PRIMARY, 19; CILD19

External Links:
 
Xenbase Gene ID XB-GENE-946667 XB-GENE-6487993 XB-GENE-17331602
Gene Symbol lrrc6 lrrc6.L lrrc6.S
Chromosome Chr06 chr6L
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2
CDS Gene model Gene model
Entrez Gene 394985
108719416
mRNA RefSeq NCBI Nucleotide
Protein RefSeq Swiss-Prot NCBI Protein
Genomic
 tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine lrrc6 lrrc6.L lrrc6.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards LRRC6 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Lrrc6 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Lrrc6 Ensembl
zebrafish
ZFIN, AGR lrrc6 ZFIN Ensembl
chicken
GEISHA LRRC6 Ensembl
fruit fly
worm
Publications
First ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6., Am J Hum Genet 2013    
Most Recent A liquid-like organelle at the root of motile ciliopathy., Elife 2018                              
All View All Papers 1 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 11 terms 0 term 0 term
PANTHER lrrc6
KEGG Pathways K19753
KOG [T] Protein phosphatase 1, regulatory subunit, and related proteins
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks lrrc6
Clones Horizon Source BioScience Horizon Source BioScience

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.14.0
Major funding for Xenbase is provided by grant P41 HD064556