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Summary Expression Gene Literature (0) GO Terms (31) Nucleotides (141) Proteins (25) Interactants (0) Wiki
XB-GENEPAGE- 947838

Gene Symbol: spast

Gene Name: spastin

Synonyms:
Add Xenopus synonyms , Nomenclature history

Gene Function: AAA+-type ATPase

Protein Function:
ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches.

Interactants:

OMIM Disease Associations: SPASTIC PARAPLEGIA 4, AUTOSOMAL DOMINANT; SPG4
 
Xenbase Gene ID XB-GENE-947839 XB-GENE-17341998 XB-GENE-947846
Genome X. tropicalis X. laevis L X. laevis S
Gene Symbol spast spast.L spast.S
Chromosome Chr05 chr5L chr5S
Molecules tropicalis laevis .L laevis.S
Gene GBrowse 8.0 GBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 GBrowse 9.1 GBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq Swiss-Prot Refseq Swiss-Prot
Genomic tropicalis laevis .L laevis.S
Genome Browser
GBrowse
tropicalis genome v8.0 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis .L laevis.S
Ensembl Ensembl
UniGene Str.10574 [+] Xl.32426 [+]
RNA-seq profile: Owens, Blitz et al. 2016 spast
Images 0 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis .L laevis.S
XenMine spast spast.L spast.S
Phenotype tropicalis laevis .L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards SPAST OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Spast MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN spast ZFIN Ensembl
chicken
GEISHA SPAST Ensembl
fruit fly
worm
WORMBASE
Publications
First:
Most recent:
View All Papers
Functional Ontologies tropicalis laevis .L laevis.S
GO 31 terms 0 term 28 terms
EC
PANTHER spast
KEGG K13254 K13254
KOG [O] AAA+-type ATPase (alt_id KOG:0740)
Reagents tropicalis laevis .L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
geneservice/RZPD imagenes geneservice/RZPD imagenes
ORF spast ORF1
Affymetrix 1.0 Str.10574.1.A1_a_at [+] Xl.19166.1.A1_at
Affymetrix 2.0 Xl2.55459.1.S1_at [+]

Symbol legend[+]

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