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Summary Expression Gene Literature (0) GO Terms (50) Nucleotides (165) Proteins (41) Interactants (16) Wiki
XB-GENEPAGE-947838
Gene Symbol:
spast

Gene Name:
spastin

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
AAA+-type ATPase

Protein Function :
ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglut...[+]



Interactants:
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Diseases: 


Disease Ontology:
hereditary spastic paraplegia 4

OMIM:
SPASTIC PARAPLEGIA 4, AUTOSOMAL DOMINANT; SPG4

External Links:
 
Xenbase Gene ID XB-GENE-947839 XB-GENE-17341998 XB-GENE-947846
Gene Symbol spast spast.L spast.S
Chromosome Chr5 chr5L chr5S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 549207
108716667
446560
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. NCBI Protein NCBI Protein  More.. RefSeq Swiss-Prot  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine spast spast.L spast.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards SPAST OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Spast MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Spast Ensembl
zebrafish
ZFIN, AGR spast ZFIN Ensembl
chicken
GEISHA SPAST Ensembl
fruit fly
worm
Publications
First
Most Recent
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Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 50 terms 16 terms 29 terms
PANTHER spast
KEGG Pathways K13254 K13254 K13254
KOG [O] AAA+-type ATPase (alt_id KOG:0740)
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks spast
ORFs spast ORF1 spast.S ORF1
Clones Horizon Source BioScience Horizon Horizon Source BioScience
Plasmids Addgene Addgene

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