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Summary Expression Gene Literature (7) GO Terms (21) Nucleotides (101) Proteins (43) Interactants (71) Wiki
XB-GENEPAGE-953739
Gene Symbol:
ncs1

Gene Name:
neuronal calcium sensor 1

Synonyms:
xfreq , flup , freq , frequenin , ncs-1 ( Add synonyms , Nomenclature history )

Gene Function:
Ca2+ sensor (EF-Hand superfamily)

Protein Function :
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin.


InterPro :
MKKS , TCP-1-like intermed sf , GroEL-like apical dom sf , Cpn60/TCP-1 [+]

Interactants:
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Diseases: 


External Links:
 
Xenbase Gene ID XB-GENE-953740 XB-GENE-953746 XB-GENE-17342716
Gene Symbol ncs1 ncs1.L ncs1.S
Chromosome Chr8 Scaffold46 chr8S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 394570
399297
432213
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More.. NCBI Protein RefSeq  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine ncs1 ncs1.L ncs1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards NCS1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Ncs1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Ncs1 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR ncs1a ncs1b ZFIN Ensembl
chicken
GEISHA NCS1 Ensembl
fruit fly
worm
Publications
First Molecular cloning and functional characterization of the Xenopus Ca(2+)-binding protein frequenin., Proc Natl Acad Sci U S A 1995          
Most Recent PLC and IP3-evoked Ca2+ release initiate the fast block to polyspermy in Xenopus laevis eggs., J Gen Physiol 2018              
All View All Papers
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 13 terms 9 terms 1 terms
PANTHER ncs1
KEGG Pathways K19932 K19932 K19932
KOG [T] Ca2+ sensor (EF-Hand superfamily)
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks ncs1
ORFs ncs1 ORF1 ncs1.L ORF1 ncs1.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

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