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Summary Expression Gene Literature (16) GO Terms (18) Nucleotides (165) Proteins (41) Interactants (357) Wiki
XB-GENEPAGE-955517
Gene Symbol:
fen1

Gene Name:
flap structure-specific endonuclease 1

Synonyms:
mf1 , rad2 , fen-1 , fen1-a , fen1-b ( Add synonyms , Nomenclature history )

Gene Function:
5'-3' exonuclease

Protein Function :
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is ...[+]



Interactants:
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Diseases: 


External Links:
 
Xenbase Gene ID XB-GENE-955518 XB-GENE-955523 XB-GENE-6254462
Gene Symbol fen1 fen1.L fen1.S
Chromosome Chr04 chr4L chr4S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 549759
394303
394311
mRNA RefSeq RefSeq RefSeq
Protein RefSeq RefSeq Swiss-Prot RefSeq Swiss-Prot
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine fen1 fen1.L fen1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards FEN1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Fen1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Fen1 Ensembl
zebrafish
ZFIN, AGR fen1 ZFIN Ensembl
chicken
GEISHA FEN1 Ensembl
fruit fly
FLYBASE Fen1 Ensembl
worm
Publications
First Complementation of the DNA repair defect in xeroderma pigmentosum group G cells by a human cDNA related to yeast RAD2., Nature 1993  
Most Recent HMGB1 Stimulates Activity of Polymerase β on Nucleosome Substrates., Biochemistry 2017  
All View All Papers 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 18 terms 11 terms 11 terms
PANTHER fen1
KEGG Pathways K04799 K04799 K04799
KOG [L] 5'-3' exonuclease (alt_id KOG:2519)
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks fen1
ORFs fen1.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience

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