ezh2 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (8)

Nucleotides (284)

Interactants (20)

XB-GENEPAGE-956214

[provisional- machine annotated only] Gene Symbol: ezh2 [Predicted: Source is Human Entrez Gene] Gene Name: enhancer of zeste homolog 2 [Predicted: Source is Human Entrez Gene] Synonyms: enx1, ezh1, kmt6, enx-1, xez Add Xenopus synonyms Gene Function: Transcriptional repressor EZH1 Interactants: eed(5) , suz12(3) , rbbp4(2) , bmi1(1) , egr2(1) , en2(1) , ezh1(1) View All

XB-GENE-956215

XB-GENE-956220

XB-GENE-6252001

Molecules		tropicalis	laevis a		laevis b
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene		Entrez Gene
mRNA		Refseq >NM_001017293\|Xenopus (Silurana) tropicalis enhancer of zeste homolog 2 (ezh2), mRNA CGGTAGTGCAATAGGGATTCCATCGGTAAGGAGATTCGGGTAGTAAGAACGGAAGAGGAGAGCCAGGCGAAGGGGAGACGGTCATAGACACGGATAATCATGGGCCAGACGGGCAAGAAATCTGAGAAGGGACCGGTGTGTTGGCGTAAGCGGGTGAAATCGGAGTACATGCGCTTGCGGCAACTCAAGAGATTTAGACGAGCAGATGAAGTAAAGAGCATGTTTAACACAAATCGGCAAAAGATTATGGAACGAACAGAGATACTAAATCAAGAGTGGAAACAGCGCAGAATCCAGCCAGTGCATATAATGACTACAGTCAGTTCTTTGCGAGGGACCAGAGAGTGCTCTGTGACCAGTGATTTAGATTTTCCAAAGCAAGTTATACCTTTAAAAACACTTACTGCTGTAGCCTCTGTGCCTATTATGTATTCATGGTCTCCTCTCCAGCAGAATTTCATGGTGGAAGATGAAACTGTTCTGCATAATATTCCATATATGGGTGATGAGGTTTTGGACCAAGATGGGACATTTATTGAAGAACTCATTAAAAACTATGATGGAAAAGTTCATGGAGATAGGGAATGCGGTTTCATTAACGATGAGATATTTGTGGAGTTAGTCAATGCATTGGCACAATATAGTGATTATGAAGACGATGAAGATGGAGATGACAATCAAGATGATGAGAGGGATGACACTGCAAAAGATCAAGATGATAACATGGAGGACCAAGAAACTCAGCCTCTCAGGAAGTTCCCCTCTGATAAAATTTTTGAAGCAATATCCTCAATGTTTCCAGACAAGGGTACATTGGAAGAACTGAAAGAAAAATACAAGGAATTAACAGAACAACAGCTTCCAGGGGCACTTCCACCAGAGTGCACCCCAAATATAGATGGGCCAAATGCAAAATCTGTGCAACGAGAGCAGAGTCTTCATTCATTCCATACCCTGTTTTGTAGGCGATGTTTTAAGTATGATTGTTTTCTGCACCCATTTCATGCTACTCCTAATACTTACAAACGGAAGAACAATGAAGCAGCAAATGATGGAAAACCTTGTGGACCACACTGCTACCAGCTTTTGGAAGGAGCACGGGAGTTTGCTGCAGCTTTGACAGCAGAACGAATAAAGACACCACCAAAGCGCCCTAGTGGTCGCCGAAGAGGTAGACTTCCCAACAACACCAGCAGACCAAGCACACCAACTGTAAATGTGTTAGAAGCCAAGGACACTGATAGTGACAGAGAAGCCGGCACTGAAACTGGAGGGGAAAGCAATGATAAGGAGGAAGAAGAGAAAAAAGATGAGACCTCAAGCTCCTCTGAAGCAAACTCTCGGTGCCAGACACCAATAAAAATGAAGCCAAATATCGAGCCACCTGAAAATGTGGAATGGAGTGGTGCAGAGGCCTCCCTATTTAGAGTGCTAATTGGAACCTATTATGACAACTTCTGTGCAATTGCAAGGTTGATTGGTACCAAGACATGCCGGCAAGTCTATGAGTTTAGAGTAAAGGAATCCAGTATTATTGCTCCTGTTATTGCTGAGGATGTCGACACTCCTCCGAGAAAGAAAAAAAGGAAACACAGACTTTGGGCAGCGCACTGCAGGAAAATACAGCTGAAAAAAGATGGTTCCTCAAACCATGTTTACAATTACCAGCCATGTGATCACCCCCGCCAGCCCTGTGACAGCTCATGCCCCTGTGTCATAGCCCAGAACTTTTGTGAGAAGTTCTGTCAGTGCAGCTCTGAATGCCAAAACAGGTTTCCTGGATGCCGCTGTAAAGCTCAGTGCAATACTAAGCAGTGCCCTTGCTACCTGGCTGTACGGGAGTGTGACCCAGACCTGTGTTTAACTTGTGGGGCTGCGGATCACTGGGACAGTAAGAATGTATCCTGCAAGAACTGCAGCATTCAGCGCGGTTCCAAGAAGCATTTGCTGTTGGCTCCTTCTGACGTTGCTGGTTGGGGGATCTTCATCAAAGACCCTGTACAGAAAAACGAGTTCATCTCTGAGTACTGTGGAGAGATCATATCCCAGGATGAAGCTGATCGAAGAGGAAAGGTGTATGATAAATACATGTGTAGCTTCCTCTTCAACTTGAACAATGATTTTGTAGTAGATGCAACAAGAAAAGGCAACAAAATCCGATTTGCAAACCATTCTGTGAATCCAAACTGCTATGCAAAAGTAATGATGGTAAATGGAGACCATAGAATAGGGATTTTTGCGAAGAGAGCCATTCAAACGGGTGAAGAACTCTTCTTTGATTACAGATACAGCCAAGCAGATGCTCTGAAATATGTGGGTATTGAGAGAGAAATGGAAATCCCCTGATTCTAGCTACCTCCTTCTGAAACCCATGCCTTACCTTCTTCAGGAATTTCTTACGCGCAATTTTAGATACAAGAGGGGAAGAAAATGCAAGCTGAAGTTCTGAGTTACCGAGTACTGTAACAGTAATTTATAGTGGTCTGACCATAATGAAACGACTCTTTCCTTTGCCACTTGCATTGTATTTTGTACCTAGGAACGTTTGGCAATAATGTTATTCAGGTACATGTCCCACCTCAAATAAAATATACTTGAACTTCTGTAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001090417\|Xenopus laevis enhancer of zeste homolog 2 (ezh2-a), mRNA GCCTGGGGCTGGCGGTAGTGCAAAAGGGATTCCATCGGTAAGGAGTTTCGGGTAGGAAGTACGGAGTGGAGAACCAGGCGACGGGGAGACGGCCATAGACAAGTTTAAGAAGTTCTTTTGTAGACAAGACTGATCAAAAGTTGTGCAAGTCGGCGACTGTTGCATGGTACTGAGCGACCATTCATCCTTTGGATAATCATGGGCCAGACGGGGAAGAAATCTGAGAAGGGACCGGTGTGTTGGCGGAAGCGGGTGAAATCGGAGTACATGGCGTTACGGCAACTCAAAAAATTTAGACGAGCAGATGAAGTAAAGAGCATGTTTAACACAAATCGGCAGAAGATTATGGAACGAACTGAGATTTTAAATCAAGAGTGGAAACAGCGCAGAATCCAGCCTGTGCATATAATGACTACAGTCAGTTCTTTACGAGGGACTAGAGAGTGCTCTGTGACCAGTGATTTAGATTTTCCAAAGCAAGTTATACCTTTGAAAACACTCACTGCTGTAGCCTCTGTGCCTATTATGTATTCCTGGTCTCCTCTCCAGCAGAATTTTATGGTCGAAGATGAAACTGTTCTGCATAATATTCCATATATGGGCGATGAGGTTTTGGACCAAGATGGCACATTTATTGAAGAACTCATTAAAAATTATGATGGAAAAGTTCATGGAGACAGGGAATGCGGTTTCATTAATGATGAGATATTTGTGGAGTTAGTCAATGCATTGGCTCAATACAGTGATTATGAAGACGATGAAGATGGAGATGACAATCAAGACGATGAGCAGGATGACACGGCAAAAGATCAAGATGATAACATGGAGGACAAGGAAACTCAACCTCTCAGAAAGTTTCCCTCTGATAAAATTTTTGAAGCAATTTCCTCAATGTTTCCAGACAAAGGTACATCTGAAGAACTAAAGGAAAAATACAAGGAATTAACAGAACAGCAACTTCCAGGGGCACTTCCACCAGAGTGCACCCCAAATATAGATGGGCCAAATGCAAAATCTGTACAACGAGAGCAGAGTCTTCACTCATTCCATACCCTGTTTTGTAGGCCATGTTTTAAGTATGATTGTTTTTTGCACCCGTTTCATGCCACTCCTAATACTTACAAAAGGAAGAACAATGAAGCGGCAAATGATGGAAAACCTTGTGGACCACACTGCTACCAGCTTTTGGAAGGAGCACGGGAGTTTGCTGCAGCTTTGACAGCAGAAAGAATAAAGACACCACCAAAGCGCCCTAGTGGTCGCCGAAGAGGTAGACTTCCCAACAACACCAGCAGGCCAAGCACACCAACTGTAAATGTGTCAGAAGCCAAGGACACGGATAGCGACAGAGAAGCTGGCACGGAAACTGGCGGGGAAAGCAATGATAAGGAGGAGGAAGAGAAAAAAGATGAGACTTCCTCCTCTTCTGAAGCAAACTCCCGCTGCCAGACACCAATAAAAATGAAGCCAAATATCGAGCCACCTGAAAATGTGGAATGGAGTGGTGCTGAGGCCTCCCTATTTCGAGTGCTAATTGGAACCTATTATGACAACTTCTGTGCAATTGCAAGATTGATTGGTACCAAGACATGCCGGCAAGTCTATGAGTTTAGAGTAAAGGAATCCAGTATTATTTCTCCTGTCATTGCTGAGGATGTTGACACTCCTCCGAGAAAGAAAAAGAGGAAACACAGGCTTTGGGCAGCACACTGCAGGAAAATACAACTGAAAAAAGATGGTTCTTCAAACCATGTTTACAATTACCAGCCGTGTGATCACCCCCGCCAGCCCTGTGACAGCTCATGCCCCTGTGTCATAGCCCAGAACTTTTGTGAGAAGTTCTGCCAGTGCAGCTCTGAATGCCAAAACCGGTTTCCTGGATGCCGCTGTAAAGCACAGTGCAATACCAAGCAGTGCCCTTGCTACCTGGCTGTACGGGAGTGTGACCCAGACCTGTGCTTGACTTGTGGGGCTGCTGATCACTGGGACAGTAAGAATGTGTCCTGCAAGAACTGCAGCATTCAGCGCGGTTCCAAGAAGCATTTGCTTTTGGCTCCTTCTGATGTTGCTGGCTGGGGGATCTTCATCAACGACACTGTACAGAAAAACGAGTTCATCTCTGAGTACTGTGGAGAGATCATATCCCAGGATGAAGCTGATCGAAGAGGGAAAGTGTATGATAAATACATGTGTAGCTTCCTCTTCAACTTGAACAATGATTTTGTGGTAGATGCAACACGAAAAGGCAACAAAATCCGATTTGCAAACCATTCTGTGAATCCAAACTGCTATGCAAAAGTAATGATGGTTAACGGAGACCATAGAATAGGGATTTTTGCGAAGAGAGCCATTCAGACGGGTGAAGAACTCTTCTTTGATTACAGATACAGCCAAGCAGATGCGCTGAAATATGTGGGTATTGAGAGAGAAATGGAAATCCCCTGATTCTAGCTACCTCCTTATGAAACCCATGCCTTACCTTCTTCAGGAATTTCTTACTCGCAATTTTAGATACAAAGAGGGGAAGAAAAATGTGGGAAGCTGAAGTTCTGAGTTACCGAGTACTGTAACAGTAATTTATAGTGATCTGACCATAACGCAACGACTTTCCTTTGCCAGTTGCAATGTATTTTGTACCTAGGAACGTTTGGCAATAATGTTATTCAGGTACATGTCCCACCTCAAATAAAATATACTTGAACTTCTGTATTTTCTGTACTTTTCATTTGTCAGGCTACAACTTTAGATATTAAATAGATATGAAAAAAAAAA		NCBI Nucleotide >BC073418\|Xenopus laevis hypothetical protein LOC443646, mRNA (cDNA clone IMAGE:5515392), partial cds GACAGAGAGAGCTAAGCGCTTGTCATGGGGGTGGATGAACGCTGTGAGAGGTGGAGGTTTATTTGGGATATTTAGTTTGGCGGTAGTGGGATTCCATCGGTAAGGAGATTCCGGTAGGAAGTACGGAGAAGCAGAGCCAGGCGAAGGGGAGGCGGTCACAGACAAGGATAATCATGGGCCAGACAGGCAAGAAATCTGAGAAGGGAGCGGTGTGTTGGCGCAAGCGGGTGAAATCGGAGTACATGCGCTTAAGGCAACTCAAGAGATTTAGACGAGCAGATGAAGTAAAGAGCATGTTTAACACAAATCGTCAAAAGATAATGGAACGAACTGAGATTTTAAATCAAGAGTGGAAACAGCGCAGAATCCAGCCTGTGCACATAATGACTACAGTCAGTTCTTTAAGAGGGACTAGAGAGTGCTTTGTGACTAGTGATTTAGATTTCCCAAAACAAGTTATACCTTTGAAAACACTCACTGCTGTAGCCTCTATGCCTATTATGTATTCCTGGTCTCCTCTTCAGCAGAATTTCATGGTGGAAGATGAAACTGTTCTGCATAATATTCCATATATGGGTGATGAGGTTTTGGACCAAGATGGGACATTTATTGAAGAACTCATTAAAAACTATGATGGAAAAGTTCATGGAGACAGAGAATGCGGTTTCATTAATGATGAGATATTTGTGGAGTTAGTCAATGCATTGGCACAATACAGCGATTATGAAGACGATGAAGATGGAGAGGATAATCAAGATGATGAGAGGGATGACATAACAAAAGATCAGGATGATAACATGGAGGAAAAGGAAACTCTGCCTCTCAGGAAATTTCCCTCTGATAAAATTTTTGAAGCAATATCCTCAGTGTTTCCAGACAAGGGTACATCTGAAGAACTGAAAAAAAAAAAAAAA
Protein		Refseq >NP_001017293\|histone-lysine N-methyltransferase EZH2 [Xenopus (Silurana) tropicalis] MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFNTNRQKIMERTEILNQEWKQRRIQPVHIMTTVSSLRGTRECSVTSDLDFPKQVIPLKTLTAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALAQYSDYEDDEDGDDNQDDERDDTAKDQDDNMEDQETQPLRKFPSDKIFEAISSMFPDKGTLEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNNEAANDGKPCGPHCYQLLEGAREFAAALTAERIKTPPKRPSGRRRGRLPNNTSRPSTPTVNVLEAKDTDSDREAGTETGGESNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASLFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVIAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP UniProtKB	Refseq >NP_001083886\|histone-lysine N-methyltransferase EZH2 [Xenopus laevis] MGQTGKKSEKGPVCWRKRVKSEYMALRQLKKFRRADEVKSMFNTNRQKIMERTEILNQEWKQRRIQPVHIMTTVSSLRGTRECSVTSDLDFPKQVIPLKTLTAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALAQYSDYEDDEDGDDNQDDEQDDTAKDQDDNMEDKETQPLRKFPSDKIFEAISSMFPDKGTSEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRPCFKYDCFLHPFHATPNTYKRKNNEAANDGKPCGPHCYQLLEGAREFAAALTAERIKTPPKRPSGRRRGRLPNNTSRPSTPTVNVSEAKDTDSDREAGTETGGESNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASLFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIISPVIAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFINDTVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP UniProtKB		NCBI Protein >AAH73418\|LOC443646 protein [Xenopus laevis] MGQTGKKSEKGAVCWRKRVKSEYMRLRQLKRFRRADEVKSMFNTNRQKIMERTEILNQEWKQRRIQPVHIMTTVSSLRGTRECFVTSDLDFPKQVIPLKTLTAVASMPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALAQYSDYEDDEDGEDNQDDERDDITKDQDDNMEEKETLPLRKFPSDKIFEAISSVFPDKGTSEELKKKKK UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis a		laevis b
UniGene		Str.1297	Xl.19136 [+] Xl.34723		Xl.85841
Unigene EST Profile		EST Profile	EST Profile		EST Profile
GEO data			GEO		GEO
Images		4 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	EZH2
mouse		MGI	Ezh2	All(11) Targeted, knock Out(4) Targeted, other(7)
zebrafish		ZFIN	ezh2	1 Lines(s)

Publications
First:		The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos. [Mol Cell Biol 2001]
Most recent:		PRC2 during vertebrate organogenesis: A complex in transition. [Dev Biol 2012]
		View All Papers

Functional Ontologies
GO: Molecular:		DNA binding
Biological:
Cellular Component:		nucleus
EC:
KOG:		[K] Transcriptional repressor EZH1

Reagents		tropicalis	laevis a		laevis b
Clones		open biosystems	open biosystems		open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes		geneservice/RZPD imagenes
Affymetrix 1.0		StrJgi.3836.1.S1_at [+] Str.46439.1.A1_at StrEns.6409.1.S1_s_at	Xl.19136.1.S1_at
Affymetrix 2.0			Xl2.19136.1.S1_a_at [+] Xl2.34723.1.S1_at

Symbol legend[+]