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Summary Expression Gene Literature (55) GO Terms (12) Nucleotides (299) Proteins (23) Interactants (68) Wiki
XB-GENEPAGE- 961444

Gene Symbol: kif2c

Gene Name: kinesin family member 2C

Synonyms: mcak , kcm1 , XKCM1
Add Xenopus synonyms , Nomenclature history


Gene Function: Kinesin-like protein

Protein Function:
Promotes ATP-dependent removal of tubulin dimers from microtubules. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:8548824). May play a role in chromosome congression and may be required for the lateral to end-on conversion of the chromosome-microtubule attachment.

Interactants: aurkb (18) , ckap5 (15) , kin (8) , incenp (6) , ran (6) , tpx2 (6) , mapre1 (5) View All

OMIM Disease Associations:
 
Xenbase Gene ID XB-GENE-961445 XB-GENE-17344777 XB-GENE-961451
Genome X. tropicalis X. laevis L X. laevis S
Gene Symbol kif2c kif2c.L kif2c.S
Chromosome Chr04 chr4L chr4S
Molecules tropicalis laevis .L laevis.S
Gene GBrowse 8.0 GBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 GBrowse 9.1 GBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq TrEMBL Refseq Swiss-Prot
Genomic tropicalis laevis .L laevis.S
Genome Browser
GBrowse
tropicalis genome v8.0 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis .L laevis.S
Ensembl Ensembl
UniGene Str.45172 [+] Xl.43865
RNA-seq profile: Owens, Blitz et al. 2016 kif2c
Images 1 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis .L laevis.S
XenMine kif2c kif2c.L kif2c.S
Phenotype tropicalis laevis .L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards KIF2C OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Kif2c MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN kif2c ZFIN Ensembl
chicken
GEISHA KIF2C Ensembl
fruit fly
worm
WORMBASE
Publications
First: XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly. [Cell 1996]
Most recent: Mitotic noncoding RNA processing promotes kinetochore and spindle assembly in Xenopus. [J Cell Biol 2016]
View All Papers 1 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis .L laevis.S
GO 4 terms 0 term 11 terms
EC plus-end-directed kinesin ATPase
PANTHER kif2c
KEGG K10393 K10393
KOG [Z] Kinesin-like protein (alt_id KOG:0246)
Reagents tropicalis laevis .L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
geneservice/RZPD imagenes geneservice/RZPD imagenes
Antibody Kif2c Ab1 , Kif2c Ab2 , Kif2c Ab3 Kif2c Ab1 , Kif2c Ab2 , Kif2c Ab3
ORF kif2c ORF1
Affymetrix 1.0 Str.4037.1.S1_at [+] Xl.3533.1.S1_a_at [+]
Affymetrix 2.0 Xl2.43865.1.S1_at

Symbol legend[+]

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