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Summary Expression Gene Literature (2) GO Terms (12) Nucleotides (111) Proteins (43) Interactants (155) Wiki
XB-GENEPAGE-961994
Gene Symbol:
klhl12

Gene Name:
kelch like family member 12

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes

Protein Function :
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in...[+]


InterPro :
BTB/POZ dom , Kelch 1 , SKP1/BTB/POZ sf , BACK [+]

Interactants:
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Diseases: 


External Links:
 
Xenbase Gene ID XB-GENE-961995 XB-GENE-961998 XB-GENE-17330226
Gene Symbol klhl12 klhl12.L klhl12.S
Chromosome Chr2 chr2L chr2S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100127776
431860
108709500
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More.. NCBI Protein NCBI Protein  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine klhl12 klhl12.L klhl12.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards KLHL12 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Klhl12 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Klhl12 Ensembl
zebrafish
ZFIN, AGR klhl12 ZFIN Ensembl
chicken
GEISHA KLHL12 Ensembl
fruit fly
worm
Publications
First The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation., Nat Cell Biol 2006  
Most Recent Dimerization quality control ensures neuronal development and survival., Science 2018  
All View All Papers
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 8 terms 10 terms 0 term
PANTHER klhl12
KEGG Pathways K10450 K10450 K10450
KOG [TR] Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks klhl12
ORFs klhl12.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

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