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XB-GENEPAGE-961994
Gene Symbol:
klhl12
Gene Name: kelch like family member 12
Synonyms:
( Gene Function: Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Protein Function
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Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in...[+]
Interactants:
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Diseases: External Links:
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Xenbase Gene ID | XB-GENE-961995 | XB-GENE-961998 | XB-GENE-17330226 | |||||
Gene Symbol | klhl12 | klhl12.L | klhl12.S | Chromosome | Chr2 | chr2L | chr2S | |
Molecules | X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genomic Sequence |
Version 10.0
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Version 9.1
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Version 9.1
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CDS |
Gene model
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Gene model
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Gene model
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Entrez Gene |
100127776
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431860
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108709500
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mRNA |
NCBI Nucleotide
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NCBI Nucleotide
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NCBI Nucleotide
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Protein
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Genomic |
X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genome Browser (Click image to open in Genome Browser)
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Genomic Synteny | Genomicus PANTHER | |||||||
Expression | Development Stages | Embryonic Tissues | Adult Tissues | |||||
Summary for |
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More Information |
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Data Mining | X. tropicalis | X. laevis.L | X. laevis.S | |||||
XenMine | klhl12 | klhl12.L | klhl12.S | |||||
Orthology |
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mouse |
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rat |
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zebrafish |
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chicken |
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fruit fly |
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worm |
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Publications | ||||||||
First |
The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation., Nat Cell Biol 2006 |
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Most Recent |
Dimerization quality control ensures neuronal development and survival., Science 2018 |
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All | View All Papers | |||||||
Functional Ontologies | X. tropicalis | X. laevis.L | X. laevis.S | |||||
GO | 8 terms | 10 terms | 0 term | |||||
PANTHER | klhl12 | |||||||
KEGG Pathways | K10450 | K10450 | K10450 | |||||
KOG |
[TR] Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes
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Reagents | X. tropicalis | X. laevis.L | X. laevis.S | |||||
CRISPRscan Tracks | klhl12 | |||||||
ORFs | klhl12.L ORF1 | |||||||
Clones | Horizon Source BioScience | Horizon Source BioScience | Horizon | |||||
Plasmids | Addgene | Addgene |
Symbol legend:



