[provisional- machine annotated only] Gene Symbol: lig4 [Predicted: Source is Human Entrez Gene] Gene Name: ligase IV, DNA, ATP-dependent [Predicted: Source is Human Entrez Gene] Add Xenopus synonyms Gene Function: ATP-dependent DNA ligase IV Interactants:

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001016981|Xenopus (Silurana) tropicalis ligase IV, DNA, ATP-dependent (lig4), mRNA AAGACAAGCCGAGGCACTGACCAGGGGGTGCTAGAGGGACTAAACGCCAAAGAATAGGTATATAAATCCTAATGTCTGCAACAAAAGCCTCCGATTCTGCAGCCGAACGTACTGTGGCCTCACAAGTTCCTTTTGCTGATCTCTGCTGCACTCTTGAAAAAGTTCAAAAATGCAAAAACAGAACTGAGAAAAGTCACATTTTTAAACAATTCGTTGATTCATGGAGAAAATTTCATGAAGCCCTTCATAAAAGTCAGCCAAAAACAACAGATTCTTTCTATCCAGCCATGCGGCTTGTAGTTCCACAACTTGAAAGAGAGAGAATGGCTTATGGAATCAAAGAAACTATGCTTGCTAAATTGTACATTAAGGTTTTAGGCTTGCCAAAAGAAGGCAAAGATGCAATAAAACTTTTGAATTATAGATCGCCAACTAGTTCACATAGTGATGCAGGGGATTTTGCAGCCATTGCTTATTTTGTTCTCAAGTCAAGATGCAGAAAAGAGGGTAGCTTGTCAATACAAGAAGTAAATTACCATTTAGATTCAATTGCTAATAATAATGCAGCAAAAAAGAAGGAACTCATAGAAAAAAGTTTGCTGCATTTGATTGCTAACACGACTGCTCTTGAACAAAAGTGGCTCATCAGAATGATTATTAAGGACATGAAACTGGGTTTTAGCCAGCAAACAGTTTTCTCCATCTTCCATCCCGACGCAGCAGAGCTGCATAATGTTACTACCGATCTTGAGAAAGTTTGTATTCAGCTGCATGATCCTAATGTGTGTCTCAGTGATGTTTCCATATCAATGTTCTCTGCTTTTAAACCAATGCTGGCTGCCATTGCCAATATTCAGAATATTGAAAAGCAAATGAACCACCAGAGTTTTTACATTGAAACAAAACTTGATGGAGAACGAATGCAGATGCACAAAGATGGGGACGTATATAAATATTTCTCACGGAATGGATTTGATTACACACAGCAGTTCGGTGCATCTCCTCTTGAAGGTTCTTTGACGCCATATATTCACAATGCTTTTAGTCTGAACATACAAAATTGCATTCTAGATGGAGAAATGATGGCATACAATCCAAATACTCAGACTTTCATGCAAAAAGGAAATAAGTTTGATATTAAACGCATGGTGGATGATTCTGAGTTGCAAACTTGTTACTGTGTTTTTGATGTTCTGTTGCTTAATGATCAAAAATTGGCACATGAAACTCTCAGAAAAAGATATGACATTCTGCAAGAGATTTTTATCCCAATTCCAGGCAGATTCCATATTGTTGATAAAACAGAAGCAAGCACAAAAAAGAATGTTGTGGATGCACTTAATGAAGCAATTGATAAAAGGGAAGAAGGCATTATGGTTAAAGATCCAATGTCTATCTACAAACCAGACAAACGTGGGGAAGGATGGCTGAAGATTAAGCCTGAATATGTAAATGGCTTAATGGATGAGCTAGACCTAATCATCATTGGAGGCTACTGGGGAAAAGGTTCCCGTGGTGGAATGATGTCCCATTTCTTATGTGGTGTTGCCGAAGCATCAGGTCCTGGGGAAAAACCATCTGTTTTTCACTCAATTTGCCGTGTTGGCTCTGGTTATACCATGAAAGAATTATTTGATCTTGGTTTAAAGTTGGCTCCTCACTGGAAAACATATCGGAAAAGAGACCCACCCAGCAATATTCTTTGTGGAATAGAAAAACCTGAAGCATATATTCAACCTTGTAATTCTGTTATTGTGCAAATTAAAGCAGCAGAAATTGTTACCAGTGATATGTACAAAACTGGTTGCACTCTTAGATTCCCTCGTATTGAAAAAATAAGGGAAGATAAGGAATGGTATGACTGTATGACACTTGATGACTTGGAACAGTTTAGAGACAAAGCATCTGGGAAACTGGCTTCTAAACACTTACATATTGATGATGAACCACATGAAAAGAAACGTAAAACTGCACCAAAGCTTAAGAAAGTGATTGGAATTGTTTCACATCTAAAAGCACCTGACCTCAGTAATGTATATCAGGAGTCCTCTGTGTTTGCAGAAGTGGAGTTCTGTGTTATGAGTGGAACAGATACGCATTCTAAAGATGATCTAGCGAACATTATTGCTAAATGTGGAGGTATTGGGGTACAGAATCCTGGGGCAGATACATACTGTGTTATTGCAGGAACAGAGAATGTGAGAGTGAAAAACATTATCTGCTCAAATAAACATGACGTTGTTAAAGCAGCATGGCTATTGGAGTGTTTTGAAAGTAAAACCTTTGTGCCATGGCAGCCTCACCACATGATACACATGTGTCCATCGACTGCAGAACATTTTGCTTGCGAATATGACTGCTATGGCGATAGCTATATCACAGATACAAGCGAATATCAATTGAGAGAGGTCTTTCACAGAATGTCTAACATAAGAGAGAAAATTCCCTTTGAAATGATGGCTGATTTAGAAGAGAGGTACTCATGGAATAACTCTTCTCATAGTTTCTTTCGTCATTGCACGGTATATGTCGATAGTTTTGCCACAATTAATGACCCAACTACAAGAATAAATACATCCAGCCTAAATCTAAGAGCACTGGAACTACGTTTTTATGGTGCAAAATTAGTAAATCAGCTTGAAGAAGGAATTTCACATGTTGTAGTTGGTGAAGACTTGTCCCGTCTGGAGCAAATGAAAACTATGAGGAGGGCCATTGCAAAAAAATTTAAAATTGTGTCTGTTTCGTGGGTACTTGATTCAGTAAAAATGAGAGTGCCTCAAATGGAAAATTCATATTTGCTATAAGAATGTATGCACATATGTTGTTTTTTTTTTTTTTTTAAAGAAACCCATTTTTATATTTGTGTTTTATTTGGAAATTATGTGCTTACTTCTTACTGTATATTAGTTCTTTTAATTTTAAGAACAAAAATTTAAGTACCACCAAACTTCCAGTTTTAGAATTGGTCTTAATAATGAAAGTTTGAAATCTGTTTTATTGTCGTCTATACTGCTTTTTAATTTATGTGTCTGATTTTAAACATTAATTTTCTATGCATAATGTTTTTTCTTATATATTTTTATGTATATTTTTAATCTATGTGAATAAAAGGATGTACAGTAAAAAAAAAAAAAAAAA	Refseq >NM_001087645|Xenopus laevis ligase IV, DNA, ATP-dependent (lig4), mRNA GCATTGACCAGGGGGAGCTAAAGCTACTATACGTCAAAGAATAGGTATATAAATCCTGATGTCGACGCCGAAAGCCTCAGATTCTGCAGCCGAACATACTGTGGCCTCACAAGTGCCTTTTGCTGATCTCTGTTGTACTCTTGAAAAAATTCAAAAATGCAAAAACAGAACTGAGAAAAGTCATATTTTTAAACAGTTTGTTGATTCCTGGAGAAAATTTCATGATGCCCTCCATAAAAATCGGCCAAAAACAACCGATTCTTTCTATCCAGCCATGCGTCTTGTTCTTCCACAACTTGAAAGAGAGAGAATGGCTTATGGAATCAAAGAAACCATGCTTGCGAAATTGTACATTAAAGTTTTAGGCTTACCTAAAGAAGGCAAAGATGCATTAAAGCTTTTGAATTATAGAACGCCAACTAGTTCACATAGTGATGCAGGGGATTTTGCTGCCATTGCTTATTTTGTTCTCAAGTCACGATGCAGAAAAGAGGGGAACTTGTCGATACAAGAAGTAAATTACCATTTAGATTCAATTGCTAATAATAATGCAGCAAAAAAGAAGGAACTCATAGAAAAAAGTTTACTGCATTTAATTGCTAACACAACTGCTCTTGAACAAAAGTGGCTTATCAGAATGATTATTAAGGACATGAAACTTGGTTTTAGCCAGCAAACTATTTTCTCCATCTTCCACCCTGATGCAGTAGAACTGCATAATGTTACCACTGATCTTGAGAAAGTTTGTATTCAGCTCCATGATCCTGATGTCTGTCTCAGTGATGTTTCTATATCAATGTTCTCTGCTTTTAAACCAATGCTGGCTGCGGTCGCCAACATTCAGAATATTGAAAAACAAATGAACCACCAAAGTTTTTTCATTGAAACGAAACTGGACGGAGAACGGATGCAGATGCACAAAGATGGGGATGTGTATAAATATTTCTCACGGAATGGATTTGATTACACACAGCAGTTCGGTGCATCTCCTCTTGAAGGCTCTTTGACCCCATATGTTCACAATGCTTTTAGACTGGACACCCAAAATTGCATTCTAGATGGAGAAATGATGGCCTACAATCCAAATACTCAGACTTTCATGCAAAAAGGAAACAAGTTTGATATTAAACACATGGTAGAAGATTCTGAATTGCAAACTTGCTACTGTGTTTTTGACATACTGCTGCTTAATGATGAAAAATTAGCACATGAAACACTCAGAAAAAGATATGACATTCTGAAAGAGATTTTTATCCCAATACCAGGCAGATTCCATATTGTTGATAAAACTGAAGCAAGCACAAAAAAGAATGTTGTGGATGCACTTAATGAAGCAATTGATAAAAGGGAAGAAGGCATTATGGTTAAAGATCCAATGTCTATCTACAAACCAGACAAACGTGGGGAAGGATGGCTGAAGATTAAACCTGAATATGTTAATGGTTTAATGGATGAGCTAGACTTATTAATCATTGGAGGCTACTGGGGAAAAGGTTCCCGTGGTGGAATGATGTCCCATTTCTTATGTGGTGTTGCTGAAGCTTCAGGTCCTGGGGAAAAACCATCTGTTTTTCACTCAATTTGTCGTGTTGGCTCTGGTTACACCATGAAAGAATTATTTGATCTTGGTTTAAAGTTGGCTCCTCACTGGAAAACATATCGGAAGAGAGACCCTCCCAGCAATATTCTTTGTGGAATAGAGAAACCTGAAGTGTTTATTCAACCTTGTAATTCTGTCATTCTGCAAATTAAAGCAGCAGAAATTGTTTCCAGTGATATGTACAAAACGGGTTGCACTCTGAGATTCCCTCGCATTGAAAAAATAAGGGAAGATAAGGAATGGTATGAGTGCATGACACTTGATGACCTGGAACAGTTTAGAGACAAAGCATCGGGGAAACTGGCTTCAAAACACTTAGATGTTGATGATGAACCACATGAAAAGAAAAGAAAAACTGCACCCAAGCTTAAGAAAGTTATTGGAATTGTTTCACACCTAAAAGCACCTGACCTTAGTAATGTACATCAGGAGTCTTCTATGTTTACAGAGGTGGAGTTCTGTGTTATGAGTGGAACAGACCAACATTCTAAAGCTGATCTAGAGAACATTATTGCTAAATGTGGTGGTATTGTGGTACAGAATCCTGGAGCAGATACATATTGCGTTATTGCAGGAATCGAGAATGTGAGAGTGAAAAACGTTATCTGCTCAAATAAGCATGATGTTGTTAGAGCAGCTTGGCTATTGGAATGTTTTGAAAATAAAACTGTTGTGCCCTGGCAGCCTCACCACATGATACACATGTGCCCATCGACTGCAGAACATTTTGCTTGTGAATACGACTGCTATGGTGATAGCTATGTCACAGATACAAGTGAATATCCATTAAGAGACGTTTTTCACAGAATGTCTAAAATAAAGGAAAAAATCCCCTTTGAAATGATGGCTAATTTAGAAGAGAGATACTCATGGAATAACAGTTCTTATAATATCTTTCGTCATTGCACAGTATACGTTGATAGTTTTGCCACCATTAATGACCCAACCACAAGAATCAATACATCCAGCCTAAATATAAGAGCACTGGAGCTACGGTTTCATGGTGCCAAGTTAGTAAACCAGCTTGATGAAGGAATTTCGCATGTTCTCGTTAGTGAAGATTTGTCCCGTCTAGAGCAAATTAAAACTATGAGGAGGGCCATGGCAAAAAAATTCAAAATTGTCTCTGTTTCATGGGTACTTGATTCAGTAAAAATGAGAGTGCCTCAGATGGAAAATGCCTATTTGCTATAAAAAATATATGTATATATCTATGTTTTTAATGACTTGTTTTAAGTAACGATACAAATGTGTTTCATTTTGACACATCTTAACACATTTTTGTATTTGTGTTTTACTGGAAAATTATATGCTTACTTTCTTGCTGCCTATTCGTTCTTTTAACTTTAAGAAAAAAAGTGAAGTACCCCCAAACTTCCAGTCTTAATAATAGTCTTAATAATGGAAGTTTAAAATCTTTTATTTACATGTCTATACTACTTGTTAATTTATAAGTCTGATTTTATGCACTAGTTTTCTTTGCGTTGCGTTGTACTTTTTATATGTTTTATGTATACTTTTAATTTGTGTGAATAAAATGATGTGCCGTATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001016981|DNA ligase (ATP) 4 [Xenopus (Silurana) tropicalis] MSATKASDSAAERTVASQVPFADLCCTLEKVQKCKNRTEKSHIFKQFVDSWRKFHEALHKSQPKTTDSFYPAMRLVVPQLERERMAYGIKETMLAKLYIKVLGLPKEGKDAIKLLNYRSPTSSHSDAGDFAAIAYFVLKSRCRKEGSLSIQEVNYHLDSIANNNAAKKKELIEKSLLHLIANTTALEQKWLIRMIIKDMKLGFSQQTVFSIFHPDAAELHNVTTDLEKVCIQLHDPNVCLSDVSISMFSAFKPMLAAIANIQNIEKQMNHQSFYIETKLDGERMQMHKDGDVYKYFSRNGFDYTQQFGASPLEGSLTPYIHNAFSLNIQNCILDGEMMAYNPNTQTFMQKGNKFDIKRMVDDSELQTCYCVFDVLLLNDQKLAHETLRKRYDILQEIFIPIPGRFHIVDKTEASTKKNVVDALNEAIDKREEGIMVKDPMSIYKPDKRGEGWLKIKPEYVNGLMDELDLIIIGGYWGKGSRGGMMSHFLCGVAEASGPGEKPSVFHSICRVGSGYTMKELFDLGLKLAPHWKTYRKRDPPSNILCGIEKPEAYIQPCNSVIVQIKAAEIVTSDMYKTGCTLRFPRIEKIREDKEWYDCMTLDDLEQFRDKASGKLASKHLHIDDEPHEKKRKTAPKLKKVIGIVSHLKAPDLSNVYQESSVFAEVEFCVMSGTDTHSKDDLANIIAKCGGIGVQNPGADTYCVIAGTENVRVKNIICSNKHDVVKAAWLLECFESKTFVPWQPHHMIHMCPSTAEHFACEYDCYGDSYITDTSEYQLREVFHRMSNIREKIPFEMMADLEERYSWNNSSHSFFRHCTVYVDSFATINDPTTRINTSSLNLRALELRFYGAKLVNQLEEGISHVVVGEDLSRLEQMKTMRRAIAKKFKIVSVSWVLDSVKMRVPQMENSYLL	Refseq >NP_001081114|DNA ligase (ATP) 4 [Xenopus laevis] MSTPKASDSAAEHTVASQVPFADLCCTLEKIQKCKNRTEKSHIFKQFVDSWRKFHDALHKNRPKTTDSFYPAMRLVLPQLERERMAYGIKETMLAKLYIKVLGLPKEGKDALKLLNYRTPTSSHSDAGDFAAIAYFVLKSRCRKEGNLSIQEVNYHLDSIANNNAAKKKELIEKSLLHLIANTTALEQKWLIRMIIKDMKLGFSQQTIFSIFHPDAVELHNVTTDLEKVCIQLHDPDVCLSDVSISMFSAFKPMLAAVANIQNIEKQMNHQSFFIETKLDGERMQMHKDGDVYKYFSRNGFDYTQQFGASPLEGSLTPYVHNAFRLDTQNCILDGEMMAYNPNTQTFMQKGNKFDIKHMVEDSELQTCYCVFDILLLNDEKLAHETLRKRYDILKEIFIPIPGRFHIVDKTEASTKKNVVDALNEAIDKREEGIMVKDPMSIYKPDKRGEGWLKIKPEYVNGLMDELDLLIIGGYWGKGSRGGMMSHFLCGVAEASGPGEKPSVFHSICRVGSGYTMKELFDLGLKLAPHWKTYRKRDPPSNILCGIEKPEVFIQPCNSVILQIKAAEIVSSDMYKTGCTLRFPRIEKIREDKEWYECMTLDDLEQFRDKASGKLASKHLDVDDEPHEKKRKTAPKLKKVIGIVSHLKAPDLSNVHQESSMFTEVEFCVMSGTDQHSKADLENIIAKCGGIVVQNPGADTYCVIAGIENVRVKNVICSNKHDVVRAAWLLECFENKTVVPWQPHHMIHMCPSTAEHFACEYDCYGDSYVTDTSEYPLRDVFHRMSKIKEKIPFEMMANLEERYSWNNSSYNIFRHCTVYVDSFATINDPTTRINTSSLNIRALELRFHGAKLVNQLDEGISHVLVSEDLSRLEQIKTMRRAMAKKFKIVSVSWVLDSVKMRVPQMENAYLL

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.4239	Xl.10574
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	LIG4	OMIM:606593 OMIM:254500
mouse		MGI	Lig4	All(7) Targeted, knock Out(3) Chemically Induced(1) Targeted, other(3)
zebrafish		ZFIN	lig4	4 Lines(s)

Publications
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Most recent:
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Functional Ontologies
GO: Molecular:		ATP binding DNA ligase (ATP) activity
Biological:		DNA recombination DNA repair DNA replication
Cellular Component:		intracellular
EC:		DNA ligase (ATP)
KOG:		[L] ATP-dependent DNA ligase IV

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.4239.1.S1_at	Xl.10574.1.S1_at
Affymetrix 2.0			Xl2.10574.1.S1_at

Symbol legend[+]

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