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Summary Expression Gene Literature (6) GO Terms (43) Nucleotides (285) Proteins (61) Interactants (136) Wiki
XB-GENEPAGE-966846
Gene Symbol:
chd8

Gene Name:
chromodomain helicase DNA binding protein 8

Synonyms:
KIAA2664 , duplin ( Add synonyms , Nomenclature history )

Gene Function:
Chromodomain-helicase DNA-binding protein

Protein Function :
DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppr...[+]



Interactants:
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Diseases: 


OMIM:
AUTISM, SUSCEPTIBILITY TO, 18; AUTS18

External Links:
 
Xenbase Gene ID XB-GENE-966847 XB-GENE-966850 XB-GENE-17331966
Gene Symbol chd8 chd8.L chd8.S
Chromosome Chr01 chr1L chr1S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100192376
108714926
108707032
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot NCBI Protein NCBI Protein
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine chd8 chd8.L chd8.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards CHD8 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Chd8 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Chd8 Ensembl
zebrafish
ZFIN, AGR chd8 ZFIN Ensembl
chicken
GEISHA LOC100857358 Ensembl
fruit fly
worm
Publications
First A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation., J Biol Chem 2000    
Most Recent HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome., Proc Natl Acad Sci U S A 2018                                  
All View All Papers 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 40 terms 16 terms 16 terms
PANTHER chd8
KEGG Pathways K04494
KOG [K] Chromodomain-helicase DNA-binding protein
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks chd8
Morpholinos chd8 MO1 chd8 MO1 chd8 MO1
Clones Horizon Source BioScience Horizon Horizon

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