Gene Symbol: ptgs1 Gene Name: prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) Synonyms: cyclooxygenase 1, cox1 Add Xenopus synonyms Gene Function: peroxidase/oxygenase Interactants: cox1(2) , cox4i1(1) , cox5a(1) , cox6b1(1) , cox6c(1) , cox7a1(1) , cox7c(1) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002941137|PREDICTED: Xenopus (Silurana) tropicalis prostaglandin G/H synthase 1-like (LOC100493073), mRNA ACTAAACCTAGCGACATGGCTGGACTTTGTCTCACTGTGCTGTTTGTGATTGTGACCACTTCATATTCATTGGAAGTTTCAGATAAAGTGAATCCATGCTGCTACTACCCATGTCAGCACAAGGGTGTTTGTGTGAGGTTTGAAATGGATAAATACCTATGTGACTGCACCCGAACAGGTTATTATGGTACCAACTGCACAATCCCTGAATGGTGGACAAAGTTTCGGGAATTTCTTCGTCCAAGTCCTGCTTTTTATCACTACATTTTGACCAGATTTAAGTGGTTTTGGGATATAATAAATTCTACCTTCATACGTGATGTCATTGTGAGACTTGTTTTGACAGTGCGTTCAAATTTGATACCCAGCCCACCAACCTACAATTCTGCATATGGCTACATAAGCTGGGAGGCGTATTCTAACGTCAGCTACTTTACGCGGGTTCTTCCCCCTGTCCCAGATGATTGTCCTACTCCCATGGGAACAAAAGGAAAGATGGAACTCCCAGACGCTTCTCTTCTTGTGGAGACATTTCTGAAAAGAGAAAAATTCATCCCAGACCCGCAAGGCACAAACCTCCTGTTTGCCTTCTTTGCCCAGCATTTCACGCATCAGTTTTTCAAGACATATGGCAGGATGGGACGGGGTTTCATTAAAGGATTCGGTCATGGTGTTGATCTTAGCCATATTTATGGAGACAGTTTGGAACGCCAGCATATGCTTCGTCTCTTCACAGATGGAAAACTCAAGTATCAGATAATAAATGGGGATATATATCCGCCAACAGTGGTCGAGGCTCCAGTCTTCATGATTTATCCAGACAATGTCCCCAAGGAAAAGCAGTTTGCCGTAGGGCAGGAGGTATTTGGACTCCTCCCTGGATTGATGATGTATGCAACCCTTTGGCTCCGTGAACACAATAGGGTTTGTGATATTCTGAAGAAGGAGCACCCTACTTGGGATGATGAGCAGCTGTTTCAAACTACAAGACTAATTCTTATAGGGGAGACTATAAAGATCGTCATTGAAGACTACGTGCAGCACCTGAGTGGATATTATCTGAAACTGAAATTTGATCCAGAATTATTGTTCGGCGTGCAGTTCCAGTACAGGAATCGGATTGCTGTTGAGTTCAACCAGTTATATCACTGGCATCCTCTTATTCCGGAGAAATTTCAAATACTGGAAGATGAATACAGCCACAGCCGCTTTCTCTACAATACATCCATTCTTTTAGACTATGGAGTTGAGGCTCTGGTGGAATCTTTTACAAAACAAATTGCTGGCAAGATTGGTGGAGGAAAGAACCATCACCCGGGCCTGCTGAAGGTGGCTGCAGGAGTTATTGAAGAATCTCGAAAACTCAGGCTACAACCTTTTAATGAATATCGAAAGAGATTTGGTTTGAAGGCCTATAAGTCATTCAAAGATTTAACAGGAGAAGAAATTATGTCAGCACAACTGGAAGAGTTGTATGGAGATATAGATGCACTCGAATTCTATTTGGGGCTACTTTTGGAAAAATCCAATCCAAATTCAATATTTGGAGAAAGTATGGTGGAAATAGGGGCACCATTTTCTCTTAAAGGACTCATGGGGAACCCAATTTGCTCTCCGGAATACTGGAAGCCCAGTACCTTTGGGGGAGAAACTGGGTTTAATATTGTAAAGACTGCAACGATTCAGAAGCTTGTGTGTCTCAATGTAAAACAATGTCCCTTTGTTGCATTCCACGTGCCGGACGACGTATTACCTAAATTAAAAAAATCTGATGAGCTTTAATTTTGATGAAAAGCTGCATATATTAAACTGTATTTGTCTTTTATTAATTGTAACAGTTTAGGATATTTTTTTATTATAATTTTTTCAAAGGCT	Refseq >NM_001097920|Xenopus laevis prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (ptgs1), mRNA ACGCGGGGGCAGCTTTCCATTGTAAGAAACCATAAGTAAACTTGGCAATATGGCTGGACTCTGTCTTACTATGCTGTTTATGATTGTCACCAGTTCATATTCCCTGGAAGTTTCAACTAAAGTGAATCCATGCTGCTACTACCCCTGTCAGCACAAGGGTGTTTGTGTGAGGTTTGAAATGGAGGAATACCAATGCGACTGCACCCGGACAGGCTATTATGGTACCAACTGCACAATCCCTGAATGGTGGACCAAATTTCGGGAATTAATTCGTCCAAGTCCTGCTTTTTATCACTACATTTTGACCAGATTTAAGTGGTTTTGGGATATAATCAATTCTACCTTCATACGTGATTTCATTGTGAGACTTGTTTTGACAGTGCGTTCAAATTTGATACCTAGCCCACCAACATACAATTCTGAGTATGGTTACATTAGCTGGGAGGCGTATTCTAACGTAAGCTACTTTACACGGGTTCTTCCTCCTGTGCCACATGATTGTCCTACTCCAATGGGAACAAAAGGAAAAAAGGAACTCCCAGATGCAACTTTTCTTGTGGAGACATTTCTGAAAAGAGAAAAATTCATCCCTGACCCACAAGGCACAAACCTCCTCTTTGCCTTCTTTGCCCAGCATTTTACACATCAGTTTTTCAAGACATATGGCAGGATGGGACGGGGTTTCATTAAAGGATTTGGCCATGGTGTTGATCTTAGTCATATTTATGGAGACAGTTTGGAACGCCAGCAGATTCTTCGCCTCTTCAAAGATGGAAAACTCAAATATCAGATAATAAATGGGGAAACATATCCTCCAACAGTAGTTGAAGCTCCAGTCCATATGATTTATCCAGAAAATGTCCCCAAGGAGAAGCAATTCGCAGTAGGGCAGGAGGTATTTGGACTCCTCCCTGGATTGATGATGTATGCAACCCTTTGGCTCCGCGAACACAATAGGGTTTGTGATGTTCTGAAGAAGGAGCACCCTACTTGGGATGATGAGCAGCTGTTTCAAACTACAAGACTAATTCTTATAGGGGAGACTATAAAGATCGTCATTGAAGACTATGTTCAGCATCTAAGTGGATATTATTTGAAACTAAAATTTGATCCAGAATTACTGTTTGGCGTGCAGTTCCAGTACAGGAATCGGATTGCTGTTGAGTTCAACCAGTTATATCACTGGCATCCTCTTATGCCGGAGAAATTTAAAATTATCGAAGATGAATTCGGCTATAGCAGCTTCATCTACAATACTTCCATTATTTTAGACTATGGCGTTGAGGCTCTGGTGGAATCCTTCACAAAACAAATTGCTGGCAAGATTGGTGGCGGAAAGAATCATCCACCTAGTCTGTTGAAGGTGGCTGCAGGTGTTATTGAAGAATCCCGAAACCTCAGACTACAACCTTTCAACGAATATCGAAAGAGATTTGGATTGAAGGCTTATAAATCATTCAGAGATTTAACAGGAGAAGAAAAAATGGCAGCACAATTGGAAGAGTTTTATGGAGACATAGATGCACTTGAATTTTACGTGGGGTTACTTTTGGAAAAACCCAATCCAAATTCAATATTTGGAGAAAGTATGGTGGAAATAGGTGCACCGTTCCCTCTTAAAGGACTACTGGGGAACCCAATTTGCTCTCCAGAATACTGGAAGCCCAGTACCTTTGGGGGAGAAACTGGGTTTAATATTGTAAAGACTGCCTCTATTCAGAAGCTTGTGTGTCTCAATGTAAAAACATGCCCATTTGTTGCATTCCATGTGCCAGATGTATTACCTACATTAAAAAAATCTGATGAGCTTTAATTTTGCTGAAAAGATGCATCAATTAAAAGGTATTTTTCTTTTAATGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		NCBI Protein >XP_002941183|PREDICTED: prostaglandin G/H synthase 1-like [Xenopus (Silurana) tropicalis] MAGLCLTVLFVIVTTSYSLEVSDKVNPCCYYPCQHKGVCVRFEMDKYLCDCTRTGYYGTNCTIPEWWTKFREFLRPSPAFYHYILTRFKWFWDIINSTFIRDVIVRLVLTVRSNLIPSPPTYNSAYGYISWEAYSNVSYFTRVLPPVPDDCPTPMGTKGKMELPDASLLVETFLKREKFIPDPQGTNLLFAFFAQHFTHQFFKTYGRMGRGFIKGFGHGVDLSHIYGDSLERQHMLRLFTDGKLKYQIINGDIYPPTVVEAPVFMIYPDNVPKEKQFAVGQEVFGLLPGLMMYATLWLREHNRVCDILKKEHPTWDDEQLFQTTRLILIGETIKIVIEDYVQHLSGYYLKLKFDPELLFGVQFQYRNRIAVEFNQLYHWHPLIPEKFQILEDEYSHSRFLYNTSILLDYGVEALVESFTKQIAGKIGGGKNHHPGLLKVAAGVIEESRKLRLQPFNEYRKRFGLKAYKSFKDLTGEEIMSAQLEELYGDIDALEFYLGLLLEKSNPNSIFGESMVEIGAPFSLKGLMGNPICSPEYWKPSTFGGETGFNIVKTATIQKLVCLNVKQCPFVAFHVPDDVLPKLKKSDEL	Refseq >NP_001091389|prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) [Xenopus laevis] MAGLCLTMLFMIVTSSYSLEVSTKVNPCCYYPCQHKGVCVRFEMEEYQCDCTRTGYYGTNCTIPEWWTKFRELIRPSPAFYHYILTRFKWFWDIINSTFIRDFIVRLVLTVRSNLIPSPPTYNSEYGYISWEAYSNVSYFTRVLPPVPHDCPTPMGTKGKKELPDATFLVETFLKREKFIPDPQGTNLLFAFFAQHFTHQFFKTYGRMGRGFIKGFGHGVDLSHIYGDSLERQQILRLFKDGKLKYQIINGETYPPTVVEAPVHMIYPENVPKEKQFAVGQEVFGLLPGLMMYATLWLREHNRVCDVLKKEHPTWDDEQLFQTTRLILIGETIKIVIEDYVQHLSGYYLKLKFDPELLFGVQFQYRNRIAVEFNQLYHWHPLMPEKFKIIEDEFGYSSFIYNTSIILDYGVEALVESFTKQIAGKIGGGKNHPPSLLKVAAGVIEESRNLRLQPFNEYRKRFGLKAYKSFRDLTGEEKMAAQLEEFYGDIDALEFYVGLLLEKPNPNSIFGESMVEIGAPFPLKGLLGNPICSPEYWKPSTFGGETGFNIVKTASIQKLVCLNVKTCPFVAFHVPDVLPTLKKSDEL

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.14357	Xl.6116
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	PTGS1
mouse		MGI	Ptgs1	All(3) Targeted, knock Out(2)
zebrafish		ZFIN	ptgs1	1 Lines(s)

Publications
First:		Amino acid replacement is rapid in primates for the mature polypeptides of COX subunits, but not for their targeting presequences. [Gene 2002]
Most recent:		Next generation sequencing and comparative analyses of Xenopus mitogenomes. [BMC Genomics 2012]
		View All Papers

Functional Ontologies
GO: Molecular:		peroxidase activity prostaglandin-endoperoxide synthase activity
Biological:
Cellular Component:
EC:		prostaglandin-endoperoxide synthase
KOG:		[R] Peroxidase/oxygenase

Reagents		tropicalis	laevis
Clones			EXRC - 1 clone(s)
		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.14357.1.A1_at	Xl.6116.1.A1_at
Affymetrix 2.0			Xl2.6116.1.A1_at

Symbol legend[+]

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